PAI-1, MMP-9, and NLR combined with NIHSS for predicting 90-day poor functional outcome in elderly acute ischemic stroke: a prospective observational cohort study [0.03%]
联合应用PAI-1、MMP-9和NLR结合NIHSS评分预测老年人急性缺血性脑卒中90天预后不良的观察性队列研究
Zilong Yang,Chunlan Hou,Baoai Wang
Zilong Yang
Objective: To investigate whether a multi-marker panel comprising PAI-1, NLR, and MMP-9 enhances prognostication beyond the NIHSS score in elderly patients with acute ischemic stroke, and to develop a clinically applicabl...
Short-term clinical outcomes of balloon-assisted thrombectomy for acute middle cerebral artery occlusive [0.03%]
球囊辅助取栓治疗急性大脑中动脉闭塞的短期临床疗效
Bin Liao,Xiuling Yang,Zhesi Xing et al.
Bin Liao et al.
Objective: This study aimed to evaluate the short-term efficacy and safety of balloon-assisted thrombectomy (BAT) for acute middle cerebral artery (MCA) occlusion caused by thrombus superimposed on intracranial atheroscle...
Levodopa-accelerated frailty: a hypothesis for a cumulative iatrogenic burden in Parkinson's disease [0.03%]
左旋多巴加速的衰弱：帕金森病中累加医源性负担的假说
Claus Skaaning
Claus Skaaning
Levodopa remains the cornerstone of symptomatic treatment in Parkinson's disease, providing substantial motor benefit and improved quality of life. While epidemiological studies have suggested improved survival in the modern levodopa era co...
Investigating video consultations as a new form of care for neuropalliative patients in specialized outpatient care: results from the project TANNE (telemedical answers to neurological inquires in real time) [0.03%]
一项关于视频咨询作为神经姑息患者专科门诊新型护理形式的调查：TANNE项目（实时神经医学远程医疗解答）的结果分析
Christiane Weck,Stefan Lorenzl,Kirsten Brukamp et al.
Christiane Weck et al.
Background: Currently, there is no standardized care for neuropalliative outpatients in Germany. Those who require specialized palliative care often receive it from a Specialized Outpatient Palliative Care (SOPC) team or ...
Gut microbiota dynamics and its impact on the efficacy of ACTH therapy in infantile epileptic spasms syndrome [0.03%]
婴儿痉挛症肾上腺皮质激素治疗过程中肠道菌群动态及其影响效应
Xuan Zhang,Xinyue Hu,Xiaosheng Hao et al.
Xuan Zhang et al.
Background: Infantile epileptic spasms syndrome (IESS) is a severe early-life epileptic encephalopathy with diverse etiologies, yet its precise pathogenesis remains unclear. The gut-brain axis has emerged as a key modulat...
Glymphatic dysfunction across sleep disorders: a meta-analysis of DTI-ALPS studies [0.03%]
睡眠障碍的脑淋巴系统功能损害：DTI-ALPS研究的meta分析
Xiaoxin Zhang,Dongmei He
Xiaoxin Zhang
Background: Sleep disorders are increasingly linked to glymphatic dysfunction, but whether this impairment is universal across different sleep pathologies remains unclear. ...
Urokinase for thrombolysis in patients with acute ischemic stroke: rationale and design of a phase I dose-escalation study [0.03%]
用于急性缺血性卒中的尿激酶溶栓研究一期爬坡试验设计与方案说明
Shengjun Wang,Qingfeng Ma,Xunming Ji et al.
Shengjun Wang et al.
Background: Previous evidence supports the efficacy and safety of intravenous urokinase thrombolysis in acute ischemic stroke (AIS), with additional advantages in terms of cost-effectiveness. Existing studies suggest that...
New-onset constipation at acute stage after stroke: incidence, risk factors, and impact on stroke rehabilitation [0.03%]
急性脑卒中后新发便秘的发病风险及影响因素分析
Zhaoyang Lv,Shiyu Fan,Xv Ma et al.
Zhaoyang Lv et al.
Background: The rapid increase in the global aging population poses a major public health challenge due to the prevalence of stroke. Constipation represents a significant complication of stroke, significantly impacting qu...
Identification of key genes and metabolites in acute ischemic stroke via integrated transcriptomic and metabolomic analysis [0.03%]
通过整合转录组和代谢组分析识别急性缺血性脑卒中的关键基因和代谢物
Jiayan Zhang,Xin Zhou,Dian He
Jiayan Zhang
Background: Acute ischaemic stroke (AIS) remains a leading cause of death and disability. This exploratory study integrated transcriptomic and metabolomic analyses to identify candidate hub genes and metabolites associate...
Cesar Acevedo-Triana,Destynie Medeiros,Julia Lopes Gonçalez et al.
Cesar Acevedo-Triana et al.
Social behavior depends on neural circuits that encode social identity, memory, and motivational value. These processes engage coordinated activity across hippocampal subregions, medial prefrontal cortex, thalamic and hypothalamic nuclei, a...