Cost-effectiveness analysis of irinotecan hydrochloride liposome in combination with 5-fluorouracil and leucovorin in locally advanced or metastatic pancreatic ductal adenocarcinoma [0.03%]
用于治疗局部晚期或转移性胰腺导管腺癌的盐酸伊立替康脂质体联合氟尿嘧啶和亚叶酸钙的成本效益分析
ShaoQing Zhan,PanFeng Feng
ShaoQing Zhan
Objective: This study aims to evaluate the cost-effectiveness of irinotecan hydrochloride liposome in combination with 5-fluorouracil and leucovorin (5-FU/LV) as a second-line treatment in locally advanced or metastatic p...
Pharmacovigilance study of the frequency of gastrointestinal ulceration reports associated with immune checkpoint inhibitors: insights from the FDA adverse event reporting system [0.03%]
基于美国食品药品监督管理局不良事件报告系统的免疫检查点抑制剂类药物胃肠溃疡型不良反应药物流行病学研究：来自FDA不良事件报告系统的新启示
Liqiang Lei,Lifen Wang,Sugang Shen et al.
Liqiang Lei et al.
Background: Immune checkpoint inhibitors (ICIs) have revolutionized the treatment landscape for cancer, yet they are linked to immune-related adverse events (AEs), one of which includes gastrointestinal ulceration (GU). T...
Early intervention with extracellular vesicles derived from human umbilical cord mesenchymal stem cells enhances survival and functional recovery after spinal cord injury in rats [0.03%]
人脐带间充质干细胞源外泌早期介入促进脊髓损伤后大鼠生存及功能恢复
Barbara Porto Cipriano,Rachel Santana Cunha,Thaís Alves de Santana et al.
Barbara Porto Cipriano et al.
Introduction: Spinal cord injury (SCI) is a devastating condition with high mortality and limited treatment options. Mesenchymal stem cell (MSC)-derived extracellular vesicles (EVs) have emerged as promising cell-free the...
Diabetes and traditional remedies in Medieval Persia: a historical perspective [0.03%]
糖尿病的传统疗法——从中世纪的波斯看历史上的糖尿病治疗学说
Fereshteh Safavi,Adolfo Andrade-Cetto,Sonia M Escandón-Rivera
Fereshteh Safavi
Traditional Persian Medicine (TPM) has long contributed to the diagnosis, prevention, and treatment of diabetes. Rooted in the theory of temperament, TPM classifies individuals and diseases according to four qualities: warm-dry, warm-wet, c...
Effect of 13 traditional Chinese medicine drug preparations against Neisseria gonorrhoeae [0.03%]
十三种中药复方对淋球菌的体外抑菌作用研究
Wenfeng Liao,Ke Zhou,Yan Zhang et al.
Wenfeng Liao et al.
Introduction: Gonorrhea poses severe health complications, with an estimated 82.4 million new adult infections reported globally in 2020. Currently, ceftriaxone monotherapy remains the first-line treatment in China. Howev...
TAAR9 knockout increases hippocampal serotonin and alters grooming behavior in rats [0.03%]
TAAR9敲除增加大鼠海马神经元血清素水平并改变其理毛行为
Ilya S Zhukov,Inessa V Karpova,Ramilya Z Murtazina et al.
Ilya S Zhukov et al.
Introduction: Despite their association with brain disorders, the neurophysiological roles of the trace amine-associated receptors remain poorly understood. In humans, the genomic trace amine-associated receptor cluster c...
Qingfei Dayuan granules and decoction alleviate acute lung injury via TLR4 signaling pathway modulation, gut microbiota regulation, and metabolic reprogramming [0.03%]
清肺化纤颗粒及汤剂通过调节TLR4信号通路、肠道菌群和代谢重编程缓解急性肺损伤
Huanbo Cheng,Jingwen Ha,Yuanming Ba
Huanbo Cheng
Objective: To explore and compare the therapeutic effects and underlying mechanisms of Qingfei Dayuan Granules (QFDYGs) and Qingfei Dayuan Decoctions (QFDYDs) for the treatment of acute lung injury (ALI), focusing on the ...
Correction: Renoprotective effects of GHRH agonist MR409 is associated with reduced oxidative stress and ferroptosis in diabetic mice [0.03%]
纠正：GHRH激动剂MR409的肾保护作用与糖尿病小鼠的氧化应激和铁死亡减少有关
Yueyang Liu,Rong Fu,Qi Tang et al.
Yueyang Liu et al.
[This corrects the article DOI: 10.3389/fphar.2025.1617185.]. Keywords: Klotho; diabetic nephropathy; ferrop...
Published Erratum
Frontiers in pharmacology. 2025 Nov 12:16:1737333. DOI:10.3389/fphar.2025.1737333 2025
Tigecycline pharmacodynamics in the hollow fiber system of Mycobacterium avium-complex lung disease and the utility of MICs and time-kill studies in drug development [0.03%]
泰利霉素对麻风分枝杆菌复合体肺病灌流纤维系统药动学的研究及最低抑菌浓度和杀菌曲线研究在药物研发中的应用价值
Devyani Deshpande,Shashikant Srivastava,Tawanda Gumbo
Devyani Deshpande
Background: Guideline-based therapy (GBT) drugs for Mycobacterium avium-complex (MAC) lung disease (LD) were chosen in part because they have low minimum inhibitory concentrations (MICs). Despite these low MICs, GBT achie...
Comparative safety analysis of Riluzole, Edaravone and Tofersen in ALS management: insights from FAERS database [0.03%]
来自FAERS数据库的启示：ALS管理中Riluzole、Edaravone和Tofersen安全性的比较分析
Shuang Guan,Sicun Wang,Yinli Shi et al.
Shuang Guan et al.
Background: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder. Riluzole, Edaravone, and Tofersen, three promising treatments, have distinct profiles that merit comparative analysis to guide c...