Editorial: Insights into solar radiation: therapeutic targets and innovative products [0.03%]
述评：光辐射的治疗靶点和创新产品研究新进展
Fernanda Maria Pinto Vilela,Laura A Calvo-Castro,Yris Maria Fonseca-Bazzo
Fernanda Maria Pinto Vilela
Citrus flavonoids mitigate the cisplatin-induced ovarian toxicity via dual modulation of Nrf2/HO-1 pathway and NF-κB axis [0.03%]
柑橘类黄酮通过双重调节Nrf2/HO-1信号通路和NF-κB轴缓解顺铂引起的卵巢毒性
Ahmed Abdeen,Obeid Shanab,Mohammed H Hassan et al.
Ahmed Abdeen et al.
Cisplatin (CIS) is an effective chemotherapeutic agent whose clinical use is limited by off-target toxicity, including damage to ovarian granulosa cells, characterized by oxidative stress and inflammation. Here, the cytoprotective potential...
Research progress of small molecule protein kinase inhibitors (SMKIs) in the treatment of colorectal cancer: mechanism, application, and future prospects [0.03%]
小分子蛋白激酶抑制剂治疗结直肠癌的研究进展：机制、应用及未来展望
Lei Liu,Yingjun Chen,Mingxin Guo et al.
Lei Liu et al.
Colorectal cancer (CRC) is among the most common malignancies worldwide, and advanced or metastatic disease remains difficult to treat because of tumor heterogeneity, adaptive resistance, pathway redundancy, drug-related toxicity, and limit...
Pharmacologic targeting of midasin (MDN1) reveals a potential therapeutic vulnerability in ESR1-mutant breast cancer [0.03%]
药理学靶向中期序列蛋白 MDN1 可揭示雌激素受体 1 突变型乳腺癌的潜在治疗弱点
Mounika Pamukuntla,Afia Ohemeng,Bipika Banjara et al.
Mounika Pamukuntla et al.
Introduction: Although most cases of estrogen receptor-positive (ER+) breast cancer initially respond to endocrine therapy, many patients ultimately develop resistance. A major contributor to endocrine resistance in metas...
Onatasertib re-sensitizes refractory nasopharyngeal carcinoma to immunotherapy: a Case Report [0.03%]
奥那司妥尼重塑头颈部复发/难治性鼻咽癌免疫微环境并增强免疫治疗疗效——一例报告
Peipei Zhang,Zhanpeng Zhang,Jun Liu et al.
Peipei Zhang et al.
The standard first-line treatment for patients with recurrent or metastatic nasopharyngeal carcinoma (R/M-NPC) is currently a combination of a programmed cell death protein-1 (PD-1) blockade and gemcitabine-cisplatin. However, effective opt...
S100A8/A9 as a key player in colorectal cancer: from diagnosis to therapeutic targeting [0.03%]
S100A8/A9在结直肠癌中的关键作用：从诊断到治疗靶向
Yifan Wei,Hua Hao
Yifan Wei
S100A8/A9, a key member of the calcium-binding protein family, exerts multiple biological effects through its aberrant expression, and serves as an important regulatory factor in the development and progression of colorectal cancer (CRC). I...
Chemical characterization of iridoid glycosides from Veronica persica by UHPLC-MS/MS and their in vitro anti-inflammatory activity [0.03%]
基于UHPLC-MS/MS的报春薇(veronica persica)中翼缕醇苷类成分化学表征及其体外抗炎活性研究
Hanfeng Min,Lu Tan,Wenxin Li et al.
Hanfeng Min et al.
Veronica persica: Poir., a common weed found along field ridges, has been traditionally employed in folk medicine for the treatment of severe burns. To assess the therapeutic effectiveness of Veronica persica against burns, a murine model o...
Nonpolysaccharide fraction of Lonicerae japonicae Flos attenuates cyclophosphamide-induced immunosuppression associated with modulation of the Keap1/Nrf2/HO-1/GPX4 signalling pathway [0.03%]
金银花非多糖组分通过调节Keap1/Nrf2/HO-1/GPX4信号通路缓解环磷酰胺所致免疫抑制作用
Mei Peng,Xiong Pan,Guanping Yao et al.
Mei Peng et al.
Background: Cyclophosphamide (CTX)-induced immunosuppression is closely associated with oxidative stress and ferroptosis, but effective therapeutic interventions remain limited. This study investigated the protective effe...
Sodium oligomannate reduces cerebral infarction and improves neurological function through microbiota remodeling in MCAO/R rats [0.03%]
壳寡糖通过改善脑缺血再灌注大鼠肠道菌群失调减少脑梗死并改善神经功能损伤
Jin Han,Wei Zhao,Rui Deng et al.
Jin Han et al.
Background: Ischemic stroke is the second leading cause of death worldwide, characterized by high mortality and a narrow therapeutic window for thrombolysis. Gut microbiota dysbiosis and gliosis following ischemic stroke ...
Physiologically based pharmacokinetic modeling of tafenoquine and evaluation of transporter-mediated drug-drug interactions [0.03%]
基于生理的塔纳喹药代动力学模型及其介导药物相互作用的评价研究
Luisa Oliveira Santos,Pieter Annaert,Francine Johansson Azeredo
Luisa Oliveira Santos
Introduction: The aim of the study was to develop a physiologically based pharmacokinetic (PBPK) model of tafenoquine (TQ), a new drug for the radical cure of Plasmodium vivax malaria and assess drug-drug interactions wit...