Prevalence and risk factors of burnout among community pharmacists in the Aseer region, Saudi Arabia: a cross-sectional study [0.03%]
沙特阿塞尔地区社区药剂师的职业枯竭及其影响因素的横断面研究
Moteb Khobrani,Sultan M Alshahrani
Moteb Khobrani
Background: Burnout incidents among community pharmacists continue to increase globally, resulting in impaired job performance and patient care as well as mental health deterioration. Research studies on pharmacist burnou...
Melatonin supplementation reduces delirium incidence in critically ill patients: a systematic review and meta-analysis [0.03%]
褪黑素补充可降低重症患者发生谵妄的几率：系统评价和meta分析
Xiaoyu Wu,Panxin Hu,Haopeng Wu et al.
Xiaoyu Wu et al.
Background: Delirium represents a common and severe neuropsychiatric complication among critically ill individuals, often leading to extended hospital stays, elevated mortality risk, and persistent cognitive decline. Disr...
Efficacy and safety of opioid-receptor antagonists for opioid-induced constipation: a systematic review and meta-analysis [0.03%]
阿片受体拮抗剂治疗阿片类药物致便秘的疗效和安全性：系统评价和网状Meta分析
Yuanlin Li,Yuyuan Tu,Zihao Zhou et al.
Yuanlin Li et al.
Background: Opioid-induced constipation (OIC) is a common and serious side effect of long-term opioid analgesic therapy. As traditional laxatives often show limited efficacy, it is crucial to explore treatment strategies ...
Preclinical evidence of ginkgo biloba extract on diabetic nephropathy: a systematic review and meta-analysis [0.03%]
银杏叶提取物对糖尿病肾病的药理证据：系统回顾和荟萃分析
Jiangteng Liu,Ying Tang,Zhixun Guo et al.
Jiangteng Liu et al.
Background: Diabetic nephropathy (DN) is one of the common complications of diabetes, which is the leading cause of end-stage renal disease worldwide. Ginkgo biloba extract (GBE) has shown effectiveness in DN animal model...
γ-Mangostin attenuates osteoclastogenesis and bone resorption by suppressing the PI3K/AKT/NF-κB pathway [0.03%]
Garcinia果提取物γ- Mangostin通过抑制PI3K / AKT / NF- κB通路缓解破骨细胞的生成和骨吸收作用
Jian Wei,Jiayue Xie,Zhiyang He et al.
Jian Wei et al.
Background: Postmenopausal osteoporosis (PMOP), driven predominantly by estrogen deficiency-induced hyperactivation of osteoclasts, represents a critical public health burden. The pursuit of naturally sourced inhibitors o...
Brandon Vu,Ryo Kawamoto,Priscila Villalba-Davila et al.
Brandon Vu et al.
Bile acids (BAs) are amphiphilic molecules traditionally recognized for their role in lipid digestion but have gained increased interest for their therapeutic potential. Among them, ursodeoxycholic acid (UDCA) is the most widely prescribed ...
Tumor-derived extracellular vesicles mediate cell-specific uptake and facilitate enhanced doxorubicin delivery in breast cancer [0.03%]
肿瘤来源的细胞外囊泡介导特异性摄取并促进乳腺癌道诺霉素的高效递送
Dhananjay B Alagundagi,Mahima Rachel Thomas,Vinay C Sangamesh et al.
Dhananjay B Alagundagi et al.
Background: Chemotherapy suppresses tumor growth and metastasis, but its efficacy is limited by non-specificity, systemic toxicity, poor accumulation and side effects. Extracellular vesicles (EVs) derived from cells have ...
Naeso-san, a traditional herbal formula, attenuates HCl/ethanol-induced gastric injury via MAPK and NF-κB pathway modulation in mice [0.03%]
Naeso-san通过调节小鼠MAPK和NF-κB途径减轻HCl/乙醇诱导的胃损伤
Suji Choi,In Gyoung Ju,Minji Lee et al.
Suji Choi et al.
Background: Gastric ulcers affect approximately 10% of the global population, while current acid-suppressive therapies have notable limitations including impaired digestion and long-term safety concerns. Naeso-san (NSS), ...
Serum valeric acid stimulates lung epithelial cilia assembly and improves prognosis in patients with severe respiratory infections [0.03%]
血清戊酸促进肺上皮纤毛组装并改善严重呼吸道感染患者的预后
Yabin Zhang,Yuqing Zhang,Lin Wang et al.
Yabin Zhang et al.
Introduction: Globally, respiratory infections remain a leading cause of mortality, with treatment efficacy increasingly challenged by antimicrobial resistance. This study aimed to investigate the role of serum metabolite...
Editorial: Genomic discoveries and pharmaceutical development in urologic tumors - volume II [0.03%]
评论：泌尿系统肿瘤的基因组发现及药物开发（第二部分）
Wenjia Li,Jialin Meng,Huan Yang et al.
Wenjia Li et al.