Putative identification of CASTOR1 as one of the targets of ganoderic acid a via thermal proteome profiling and molecular docking [0.03%]
Aifang Chen,Weishuai Xu,Yaxin Wang et al.
Aifang Chen et al.
In traditional Chinese medicine theory, aging is hypothesized to arise from severe deficiency of kidney essence, which is posited to induce "emptiness of the sea of marrow". Ganoderma has been documented to possess properties that nourish k...
Curcumin-berberine ointment based on multifunctional carrier accelerates wound healing in a translational porcine model of tail-biting injuries: a controlled study against oxytetracycline [0.03%]
Paweł Biernat,Dominik Marciniak,Dawid Bursy et al.
Paweł Biernat et al.
Background: Chronic wounds represent a significant clinical burden, with limited efficacy of conventional therapies, particularly in wounds complicated by necrosis and biofilms. This study evaluated the efficacy of MTC-U1...
Trilaciclib for prophylaxis of chemotherapy-induced myelosuppression in solid tumor patients: a systematic review and meta-analysis [0.03%]
Ting Yang,Pengjie Yang,Danyang Meng et al.
Ting Yang et al.
Objective: To systematically evaluate the clinical benefit and safety of trilaciclib in solid-tumor patients receiving chemotherapy and to inform clinical practice. ...
Real-world pharmacovigilance analysis of pralatrexate using the FDA adverse event reporting system database [0.03%]
Wei Yang,Qing Wu,Yu Zheng et al.
Wei Yang et al.
Introduction: Pralatrexate, the first United States Food and Drug Administration (FDA)-approved selective antifolate agent for relapsed/refractory peripheral T cell lymphoma (PTCL), has an incompletely defined postmarketi...
Discovery of potent and highly selective sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for treating diabetic nephropathy [0.03%]
Haotian Ni,Yifei Geng,Shan Xu et al.
Haotian Ni et al.
Inhibition of glucose reabsorption by SGLT2 in the kidney is a promising strategy for the treatment of diabetic nephropathy. Adverse side effects of SGLT1 inhibition can be reduced by selective inhibition of SGLT2. Here, we developed an int...
Optimized ultrasound extraction and cytotoxic activity against HeLa cervical cancer cells of total flavonoids of Physochlaina physaloides (L.) G. Don [0.03%]
Zhi Ying Sun,Jie Xu,Wei Wei
Zhi Ying Sun
Introduction: Physochlaina physaloides (L.) G. Don is a traditionally used botanical drug whose antitumor activity has been linked to flavonoid-enriched fractions. This study aimed to optimize the ultrasound-assisted extr...
Pharmacokinetic profiling of rituximab in glomerular diseases: key determinants and implications for personalized therapy [0.03%]
Jingyan Zhang,Qijun Wan,Yuan Cheng
Jingyan Zhang
Rituximab demonstrates significant efficacy in the treatment of glomerular diseases; however, considerable heterogeneity in clinical responses is observed. This variability is largely attributable to the complex pharmacokinetic profile of r...
Protective effects of salidroside on NAFLD rodent models by alleviating oxidative stress and inflammation: a meta-analysis and mechanism exploration [0.03%]
Shuai Li,Ran Hu,Lingyu Xu et al.
Shuai Li et al.
Objective: The purpose of this study was to systematically evaluate the therapeutic effect of salidroside on rodent NAFLD models through a meta-analysis of multiple animal experiments, and to explore its potential mechani...
Evaluation of the efflux inhibitory potential of gallotannin to restore drug sensitivity in XDR Acinetobacter baumannii in vitro, and a zebrafish infection model [0.03%]
Ramaravinth Manivannan,Niraimathi Muralidharan,Sadhiskumar Balavarun et al.
Ramaravinth Manivannan et al.
Introduction: Acinetobacter baumannii is a highly problematic nosocomial pathogen, designated a "red alert" organism by the Infectious Diseases Society of America. Multidrug-resistant (MDR) strains are associated with mor...
Integrative biomarker and drug target discovery in osteosarcoma: traditional experimental approaches and AI-enabled insights [0.03%]
Zhihao Gao,Chongqin Wu
Zhihao Gao
Osteosarcoma is the most common primary malignant bone tumor and remains a major clinical challenge due to frequent metastasis, chemoresistance, and pronounced molecular heterogeneity. Despite substantial advances in understanding disease b...