Pathological complete response to perioperative treatment with darolutamide plus ADT in locally advanced prostate cancer without PTEN or RB1 loss: a case report [0.03%]
达罗特胺联合ADT新辅助治疗PTEN或RB1无缺失的局部晚期前列腺癌患者并获得病理完全缓解的病例报告
Zhihui Zhang,Jiwei Zhai,Qimei Ma et al.
Zhihui Zhang et al.
Locally advanced prostate cancer (LAPC) is associated with a higher risk of recurrence and metastasis. Perioperative intensified systemic therapy may contribute to tumor downstaging. However, clinical evidence supporting darolutamide-based ...
Genetic insights revealed ADRB1 as potential target for clear cell renal cell carcinoma [0.03%]
遗传学见解揭示了ADRB1可能是透明细胞肾细胞癌的潜在治疗靶点
Honghui Zhu,Qi Lin,Zhixian Yu et al.
Honghui Zhu et al.
Background: Antihypertensive drug targets are associated with various cancers, but their relationship with clear cell renal cell carcinoma (CCRCC) risk remains unclear. ...
Empagliflozin-pirfenidone dual therapy improves cardiac function and structure in a preclinical two-hit HFpEF model [0.03%]
恩格列净-吡非尼酮联合治疗可改善两击HFpEF模型的心脏功能和结构
Yuexin Yu,Yaping Xu,Jinfu Chen et al.
Yuexin Yu et al.
Background: Heart failure with preserved ejection fraction (HFpEF) accounts for more than half of heart failure cases and is associated with substantial morbidity and mortality. Although sodium-glucose cotransporter-2 inh...
Old tale new admirers, cetuximab maintenance in metastatic colorectal cancer: a systematic review and meta-analysis [0.03%]
老药新宠，西妥昔单抗维持治疗转移性结直肠癌：系统评价和Meta分析
Yici Yan,Zhenyi Lin,Jing Yuan et al.
Yici Yan et al.
Background: metastatic colorectal cancer (mCRC) represents a major global burden and the decision on whether to pursue maintenance with cetuximab (CET) remains controversial. Therefore, this meta-analysis was performed to...
The current status and influencing factors of medication literacy among patients with cardiovascular diseases: a systematic review and meta-analysis [0.03%]
心血管疾病患者用药素养的现状及影响因素：系统评价和.meta.分析
Ting Xu,Qian Yao,Yu Ni et al.
Ting Xu et al.
Background: As an important domain of health literacy, medication literacy plays a critical role in ensuring the safe and effective use of medicines, especially among individuals with Cardiovascular Diseases (CVDs). Never...
Clinical improvement following an integrative iboga microdosing protocol in post-concussive and hypoxic brain injury syndromes: a case series [0.03%]
结合微剂量 Ibogaine 治疗脑震荡和缺氧性脑病的临床改善：一组病例报告
Burton J Tabaac,Robin L Carhart-Harris,Teresa Yung
Burton J Tabaac
Background: Traumatic brain injury (TBI) can result in prolonged post-concussive syndrome and chronic hypoxic-ischemic brain injury (HIBI) sequelae remains therapeutically challenging with the persistence of significant n...
Polysaccharides from Asparagus officinalis L.: phytochemistry, health benefits, biomedical, and food industry applications [0.03%]
芦笋多糖：植物化学、健康效益、生物医学和食品工业应用
Lihong Wu,Haizheng Bi,Mengru Zhang et al.
Lihong Wu et al.
Asparagus officinalis L. (A. officinalis) is a highly representative plant in the Asparagus L. genus, with both edible and medicinal values. As a typical macromolecular metabolite in A. officinalis, A. officinalis L. polysaccharides (AOPs) ...
Integrated metabolomics and machine learning identify predictive biomarkers via SHAP analysis for sintilimab-induced rash in lung cancer patients [0.03%]
整合代谢组学和机器学习通过SHAP分析鉴定 sintilimab 致肺鳞癌患者皮疹的预测性生物标志物
Wenxiu Tian,Hehe Tang,Xiaoyuan Liu et al.
Wenxiu Tian et al.
Background: Sintilimab-induced rash is a significant clinical challenge in lung cancer treatment, often necessitating therapy interruption or discontinuation and thereby compromising patient outcomes. The underlying mecha...
Ondansetron derivatives as potential PTP1B inhibitors for treating type 2 diabetes mellitus: in silico, in vitro, and in vivo analysis [0.03%]
奥丹司琼衍生物作为潜在的PTP1B抑制剂治疗2型糖尿病：基于计算、体外和体内分析
Fawad Naeem,Wei Jiang,Mustafeez Mujtaba Babar et al.
Fawad Naeem et al.
Introduction: Type 2 diabetes has become one of the most common causes of human deaths. Key factors that contribute to the progression of this disease include a sedentary lifestyle, high-fat diet, and genetic abnormalitie...
Methyl carnosate, a carnosic acid derivative, attenuates osteoclastogenesis via modulation of RANKL-induced NF-κB activity [0.03%]
甲基卡伦酸通过调节RANKL诱导的NF-κB活性来抑制破骨细胞生成
Lifang Zhang,Chengxu Xie,Xinyi Bao et al.
Lifang Zhang et al.
Excessive osteoclast activity underlies bone-destructive diseases including osteoporosis and rheumatoid arthritis. RANKL-induced NF-κB signaling represents a critical pathway driving osteoclastogenesis. Here, we report that methyl carnosat...