Application of network pharmacology in traditional Chinese medicine for the treatment of cardiac diseases [0.03%]
网络药理学在中医药防治心血管疾病应用中的研究进展
Xi Zhai,Xingyu Chen,Xiao Xiao et al.
Xi Zhai et al.
Many innovative traditional Chinese medicines (TCMs) play a significant role in cardioprotection against cardiac diseases by addressing the basic causes of heart attack, which presents as a dual deficiency of qi and yang. Network pharmacolo...
Curcumin: biochemistry, pharmacology, advanced drug delivery systems, and its epigenetic role in combating cancer [0.03%]
姜黄素的生物化学、药理学、药物传输系统及表观遗传学在抗癌中的作用
Shukur Wasman Smail,Peter Bergsten,Kalthum Othman Taha et al.
Shukur Wasman Smail et al.
Curcumin, the principal bioactive compound of Curcuma longa (turmeric), has received extensive scientific attention for its remarkable pharmacological and epigenetic activities, particularly in cancer prevention and therapy. This review pro...
Polyphenolic metabolites in Scutellaria baicalensis as potential candidate agents for the treatment of ischemic stroke [0.03%]
黄芩中的多酚类代谢产物作为治疗缺血性脑卒中的候选药物分子
Jinlong Zhang,Songzhe Li,Lina Huang et al.
Jinlong Zhang et al.
Objective: This study aims to elucidate the therapeutic effects of polyphenolic metabolites from Scutellaria baicalensis Georgi against ischemic stroke. The findings are expected to provide experimental evidence and novel...
Time-dependent biphasic alterations in brain metabolism following chronic ketamine exposure in mice [0.03%]
小鼠慢性氯胺酮暴露后大脑代谢的时相依赖性改变
Seo-Hyun Lim,Young-Suk Choi,Eosu Kim et al.
Seo-Hyun Lim et al.
Background: Ketamine has attracted clinical interest for its therapeutic potential, but prolonged exposure raises concerns about dependence and its long-term effects on brain metabolism. ...
Cost-effectiveness of edaravone dexborneol sublingual tablet versus concentrated solution for injection for the treatment of acute ischemic stroke in China [0.03%]
edaravone Dexborneol 舌下片与注射液治疗中国急性缺血性卒中的成本效果分析
Fan Xie,Yuqiong Lu,Zhuo Yang et al.
Fan Xie et al.
Background: Edaravone dexborneol sublingual tablet (EDSL) is a novel therapy for acute ischemic stroke (AIS), proven effective and safe. Its convenient dosage form also provides an alternative administration option, helpi...
Myasthenia gravis and community-acquired pneumonia: therapeutic challenges [0.03%]
重症肌无力患者的社区获得性肺炎治疗挑战
Xueying Chen,Jianbo Ding,Jiali Zhang et al.
Xueying Chen et al.
Myasthenia gravis (MG) patients are highly susceptible to community-acquired pneumonia (CAP) due to the need for immunosuppressive therapies and aspiration risks, with CAP representing the leading infectious cause of mortality in this popul...
Bridging bench to bedside: a dual-use framework for chromene-based anti-obesity and antiviral therapeutics [0.03%]
从实验室到临床：基于查耳非的抗肥胖和抗病毒药物的双用途框架
Sigrit Karla Chávez-Jiménez,Carlos Josué Solórzano-Mata,Beatriz Xóchitl Ávila-Curiel et al.
Sigrit Karla Chávez-Jiménez et al.
Ex vivo perfusion model of mouse liver and its application to analyze the effects of OCT1 deficiency [0.03%]
小鼠肝脏的灌流模型及其在OCT1缺陷效应分析中的应用
Vincent Rönnpagel,Felix Morof,Giuliano Ciarimboli et al.
Vincent Rönnpagel et al.
Introduction: The liver plays a critical role in drug pharmacokinetics. In in vivo experiments, it is difficult to isolate the liver's contribution to drug systemic concentrations from that of the intestine and kidneys. R...
From heart to brain: cognitive potential of propranolol and diltiazem through cholinergic enhancement via butyrylcholinesterase inhibition [0.03%]
从心脏到大脑：通过丁酰胆碱酯酶抑制增强胆碱能来提高普萘洛尔和地尔硫卓的认知潜能
Celtia Domínguez-Fernández,Amit Kumar,Rajnish Kumar et al.
Celtia Domínguez-Fernández et al.
Background: Butyrylcholinesterase (BChE) has emerged as a promising therapeutic target in the treatment of Alzheimer's disease (AD), particularly in its later stages when acetylcholinesterase (AChE) activity declines. Dru...
Development of cellular models expressing cynomolgus (Macaca fascicularis) HER2 for the functional evaluation of cross-reactive anti-human HER2 response [0.03%]
用于评估抗人HER2反应交叉反应性的食蟹猴（猕猴）HER2表达细胞系的开发
Chiara Cappello,Francesca Ruzzi,Julia Consoli et al.
Chiara Cappello et al.
Introduction: Resistance to anti-HER2 therapies and incomplete response remain considerable challenges in managing HER2-positive tumors. Furthermore, some healthy organs, like the heart, express low levels of HER2, entail...