Identifying gastric intestinal metaplasia risk based on clinical indicators: a machine learning predictive model based on the SHAP methodology [0.03%]
基于SHAP方法学的机器学习预测模型在临床指标基础上识别胃肠化生风险
Yufen Wang,Jian Bi,Shunzhe Song et al.
Yufen Wang et al.
Background: Screening for gastric intestinal metaplasia (GIM) holds significant importance for the early detection of gastric cancer. To help clinicians identify high-risk GIM patients and determine the timing of gastric ...
Ocular toxicity events of cyclin-dependent kinase 4/6 inhibitors in breast cancer: a pharmacovigilance study based on the faers database [0.03%]
来那度胺致视神经病变不良反应信号检测及病例报告详细解析：基于FAERS数据库的药物流行病学研究
Mengdi Zhang,Dongqing Pu,Minmin Yu et al.
Mengdi Zhang et al.
Background: Based on the FDA Adverse Event Reporting System (FAERS) database, this study aims to explore signals of ocular-related adverse events associated with cyclin-dependent kinase 4/6 inhibitors (CDK4/6 inhibitors),...
The therapeutic potential of Astragalus membranaceus in atopic dermatitis: from traditional applications and modern pharmacological research to regulation of the Gut-Skin Axis [0.03%]
膜荚黄芪在特应性皮炎中的治疗潜力：从传统应用和现代药理研究到调节肠道-皮肤轴
Chengshuang Lu,Yuping Zeng,Guo Wang et al.
Chengshuang Lu et al.
Atopic dermatitis (AD) is a difficult-to-treat and recurrent skin condition that often imposes a heavy burden on patients and healthcare systems due to the high costs associated with its treatment and management. Astragalus membranaceus (AM...
Computational-aided drug design strategies for drug discovery and development against oral diseases [0.03%]
口腔疾病药物发现与研发的计算辅助药物设计策略
Tong Wu,Wentao Jiang
Tong Wu
Oral diseases, including dental caries, periodontitis, oral cancer, and mucosal infections, significantly impact overall health, underscoring the need for effective drug development. However, the discovery of novel oral drugs remains challe...
Prediction and quality evaluation of quality markers of Gentiana scabra Bunge. in treatment of liver injury [0.03%]
预测和评价龙胆药材质量标志物治疗肝损伤的质量评价体系构建与效应研究
Jiayi Liu,Xuelin Yu,Jiayi Luo et al.
Jiayi Liu et al.
Introduction: Gentiana scabra Bunge. (GSB) has been demonstrated to exert nourishing effectson the liver and gallbladder. Notably, GSB extract has a marked therapeutic effect on liver injury (LI). However, the quality mar...
Retraction: Concomitant use of renin-angiotensin system inhibitors augments the efficacy of immune checkpoint inhibitors: a systematic review and meta-analysis [0.03%]
撤稿：联合使用肾素血管紧张素系统抑制剂可增强免疫检查点抑制剂的疗效：系统评价和 Meta 分析
Frontiers Editorial Office
Frontiers Editorial Office
[This retracts the article DOI: 10.3389/fphar.2024.1378577.]. Copyright © 2025 Frontiers Editorial Office.
Anticancer activity of MDM2 inhibition in 2D and bioprinted 3D retinoblastoma cell models [0.03%]
MDM2抑制在二维和生物打印的三维视网膜母细胞瘤细胞模型中的抗癌活性
Francesca Bompan,Giada Lodi,Rebecca Foschi et al.
Francesca Bompan et al.
Retinoblastoma is the most common childhood tumor affecting the retina. Pharmacological resistance or delayed intervention leads to the loss of vision. Therefore, novel therapeutic strategies need to be assessed in preclinical models that m...
Low-dose methotrexate adverse reaction risk in renal impairment: pharmacovigilance and physiological pharmacokinetic model assessment [0.03%]
生理药代动力学模型和药物警戒评估肾功能不全中低剂量甲氨蝶呤不良反应风险
Lichang Zhang,Jianling Li,Xin Wang et al.
Lichang Zhang et al.
Objective: Low-dose methotrexate (LD-MTX), a treatment regimen involving weekly doses ≤20 mg, is widely used in rheumatoid arthritis. Methotrexate (MTX) is primarily excreted via the kidneys. However, the assessment prot...
Green synthesis of silver nanoparticles using Saudi Xanthium strumarium extract: anticancer potential against breast and lung cancer cells [0.03%]
使用沙特阿拉伯Xanthium strumarium提取物绿色合成银纳米颗粒：乳腺癌和肺癌细胞的抗癌潜力
Hanan Aati,Jawaher Al-Qahtani,Areej Al-Taweel et al.
Hanan Aati et al.
Introduction: This study reports Xanthium strumarium aqueous extract-mediated synthesis of silver nanoparticles and mechanistic evaluation of their antiproliferative effects against breast (MCF-7) and lung (A-549) cancer ...
Potential of herbal formulas and bioactive metabolites in treating atherosclerosis: targeted modulation of macrophage polarization [0.03%]
中药方剂及活性代谢产物治疗动脉粥样硬化潜力：靶向调节巨噬细胞极化
Shixin Liu,Jinpeng Jing,Yunsha Zhang et al.
Shixin Liu et al.
Macrophage polarization plays a pivotal role in the pathogenesis and plaque stability of atherosclerosis (AS). In response to microenvironmental cues, macrophages differentiate into pro-inflammatory M1 or anti-inflammatory M2 phenotypes, wh...