Luteolin induces apoptosis in Philadelphia chromosome-positive acute lymphoblastic leukemia cell by regulating the PI3K/AKT signaling pathway [0.03%]
黄芩素通过调节PI3K/Akt信号通路诱导费城染色体阳性急性淋巴细胞白血病细胞凋亡
Qin Ren,Xiaobing Li,Xiangmei Ye et al.
Qin Ren et al.
Introduction: Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph + ALL) represents the most prevalent genetic subtype of adult acute lymphoblastic leukemia (ALL). Despite the availability of targeted therap...
Decoding the heterogeneity of liver-resident macrophages in chronic liver diseases: therapeutic responses to immunomodulatory strategies [0.03%]
慢性肝病中肝脏驻留巨噬细胞异质性的解析：免疫调节策略治疗反应的评估
Renbin Ouyang,Xiaocheng Li,Jianhua Hao et al.
Renbin Ouyang et al.
Chronic liver diseases (CLDs), encompassing a spectrum of etiologies including metabolic dysfunction, alcohol abuse, and viral infections, represent a significant global health burden. The progression of these diseases to fibrosis, cirrhosi...
The real-world safety profile of ranolazine: pharmacovigilance analysis of the FAERS database [0.03%]
ranolazine在真实世界中的安全概况：对FAERS数据库的药物流行病学分析
Zujun Wen,Xiang Liu,Yanbin Yi et al.
Zujun Wen et al.
Background: Ranolazine, a piperazine derivative, is used as a second-line treatment for individuals with stable or poorly managed chronic angina as well as for those whose chronic angina is not improving with other medica...
Liposomal-synthetic-cannabidiol: preliminary translational evidence of efficacy, tolerability and pharmacokinetics following repeated subcutaneous injections in two goats [0.03%]
脂质体合成大麻二酚：重复皮下注射给两只山羊后的初步转化疗效，耐受性和药代动力学证据
Yael Shilo-Benjamini,Wiessam Abu Ahmad,Dinorah Barasch et al.
Yael Shilo-Benjamini et al.
Cannabidiol (CBD), the primary non-psychoactive component of Cannabis sativa, has been gaining popularity as an analgesic in treatment of chronic painful conditions. Due to first-pass hepatic metabolism, oral CBD is considered to have low b...
DNA methylation and immune regulation in osteoporosis: emerging epigenetic targets for drug discovery [0.03%]
骨质疏松症的DNA甲基化和免疫调节：药物发现的新表观遗传学靶点
Yingli Yang,Yao Yao,Xiaoyu Cai et al.
Yingli Yang et al.
Osteoporosis (OP) is a complex skeletal disease characterized by the disruption of bone homeostasis, with immune dysregulation identified as a significant pathogenic cause. The interaction between immune cells and bone cells within the bone...
Cistanche deserticola-derived exosome-like nanovesicles target the Microbiota-GABA signaling axis to ameliorate loperamide-induced constipation [0.03%]
肉苁蓉衍生的外泌体类似纳米囊泡通过靶向微生物群-GABA信号轴来缓解洛哌丁胺致便秘
Xiaoyu Zhang,Keqiu Yan,Xinkun Bao et al.
Xiaoyu Zhang et al.
Introduction: Constipation is a prevalent gastrointestinal disorder with limited therapeutic options that often lead to laxative dependence. Gut microbiota and their metabolic regulation represent promising therapeutic ta...
Target fishing: from "needle in haystack" to "precise guidance"--new technology, new strategy and new opportunity [0.03%]
从大海捞针到精准导航——靶向捕鱼的新技术、新策略与新机遇
Juan Chen,Yafei Guo,Jing Shao et al.
Juan Chen et al.
Drug target discovery is the core breakthrough point of new drug research and development. The chemical complexity and biological network regulation characteristics of natural product systems with a long history of clinical application pose...
Bioassay-guided isolation of sesamin and fargesin from the hydroalcoholic stem extract of Zanthoxylum armatum DC. inhibited inflammation in CpG-stimulated conventional type 1 dendritic cells [0.03%]
体外实验显示碱木兰茎的水-乙醇提取物中的sesamin和fargesin成分能够抑制CpG刺激后诱导的一型树突状细胞的炎症反应
Ningthoujam Indrajit Singh,Chayan Mukherjee,Jerina Soibam et al.
Ningthoujam Indrajit Singh et al.
Introduction: Zanthoxylum armatum DC. is renowned for its medicinal values. All the plant parts have been used to treat tooth- and gum-related problems, gastro-intestinal problems, inflammation, rheumatism, and pain by th...
Clinical benefits and complication profile of IL-23 inhibitors in patients with psoriatic arthritis: a systematic review and meta-analysis [0.03%]
白介素-23抑制剂治疗银屑病关节炎的临床疗效及安全性：系统评价和meta分析
Jingxin Zeng,Ling Lin,Wei Li et al.
Jingxin Zeng et al.
Background: Psoriatic arthritis (PsA) is a chronic inflammatory disease with heterogeneous manifestations affecting both joints and skin. Interleukin-23 (IL-23) plays a central role in the Th17-mediated inflammatory pathw...
Evaluation of the pharmacokinetics, pharmacodynamics, and liver ultrasound imaging characteristics of a novel perfluoropropane microbubble in Chinese volunteers [0.03%]
评价新型含全氟丙烷微气泡超声造影剂在中国健康志愿者中的药代动力学、药效学及肝脏超声影像特征研究
Pengfei Li,Ping Du,Zhixia Zhao et al.
Pengfei Li et al.
Background and objective: Perfluoropropane (PFP), a lipidbased microbubble preparation, is a novel ultrasound contrast agent. This study aims to evaluate the pharmacokinetics, pharmacodynamics, and liver ultrasound enhanc...
Clinical Trial
Frontiers in pharmacology. 2025 Nov 7:16:1704972. DOI:10.3389/fphar.2025.1704972 2025