Cognitive synaptopathy: synaptic and dendritic spine dysfunction in age-related cognitive disorders [0.03%]
认知性突触病：年龄相关性认知障碍中的突触和树突棘功能异常
Francisco J Barrantes
Francisco J Barrantes
Cognitive impairment is a leading component of several neurodegenerative and neurodevelopmental diseases, profoundly impacting on the individual, the family, and society at large. Cognitive pathologies are driven by a multiplicity of factor...
Systolic blood pressure variability in late-life predicts cognitive trajectory and risk of Alzheimer's disease [0.03%]
晚年收缩压变异性预测认知功能和阿尔茨海默病风险
Xiao-Lu Li,Ruo-Tong Wang,Chen-Chen Tan et al.
Xiao-Lu Li et al.
Background: The relationship of systolic blood pressure variability (SBPV) with Alzheimer's disease (AD) remains controversial. We aimed to explore the roles of SBPV in predicting AD incidence and to test the pathways tha...
Modulating oxidative stress and neurogenic inflammation: the role of topiramate in migraine treatment [0.03%]
氧化应激和神经源性炎症的调节：托吡酯在偏头痛治疗中的作用
Qiao-Wen Chen,Run-Tian Meng,Chih-Yuan Ko
Qiao-Wen Chen
Migraine is a chronic, recurrent neurovascular disorder characterized by episodes closely associated with neurovascular hypersensitivity. Oxidative stress can worsen the hypersensitive state of the central nervous system, which in turn can ...
Updated insights into the NLRP3 inflammasome in postoperative cognitive dysfunction: emerging mechanisms and treatments [0.03%]
术后认知功能障碍中NLRP3炎症小体的新见解：新兴机制和治疗手段
Tian Wang,Guangwei Sun,Bingdong Tao
Tian Wang
Postoperative cognitive dysfunction (POCD) poses a significant threat to patients undergoing anesthesia and surgery, particularly elderly patients. It is characterized by diminished cognitive functions post surgery, such as impaired memory ...
Coumarin-chalcone derivatives as dual NLRP1 and NLRP3 inflammasome inhibitors targeting oxidative stress and inflammation in neurotoxin-induced HMC3 and BE(2)-M17 cell models of Parkinson's disease [0.03%]
茋类化合物通过抑制NLRP1和NLRP3炎性小体缓解神经毒素诱导的帕金森病氧化应激与炎症损伤
Te-Hsien Lin,Ya-Jen Chiu,Chih-Hsin Lin et al.
Te-Hsien Lin et al.
Background: In Parkinson's disease (PD) brains, microglia are activated to release inflammatory factors to induce the production of reactive oxygen species (ROS) in neuron, and vice versa. Moreover, neuroinflammation and ...
Olfactory dysfunction as an early pathogenic indicator in C. elegans models of Alzheimer's and polyglutamine diseases [0.03%]
秀丽隐杆线虫阿尔茨海默病和多聚谷氨酰胺疾病的嗅觉障碍模型中的早期致病指标研究
Weikang Xue,Ziyi Lei,Bin Liu et al.
Weikang Xue et al.
Neurodegenerative diseases such as Alzheimer's disease and polyglutamine diseases are characterized by abnormal accumulation of misfolded proteins, leading to neuronal dysfunction and subsequent neuron death. However, there is a lack of stu...
Iron overload regulates cognitive function in rats with minimal hepatic encephalopathy by inducing an increase in frontal butyrylcholinesterase activity [0.03%]
铁过载通过增加前额但基酰胆碱酯酶活性诱导最小肝性脑病大鼠认知功能障碍
Hua Lan,Xuhong Yang,Minxing Wang et al.
Hua Lan et al.
Background and aims: This study aimed to investigate the effect of iron overload on acetylcholinesterase activity in the frontal lobe tissue of rats with minimal hepatic encephalopathy (MHE) and its relation to cognitive ...
Jingying Pan,Qi Yao,Yankai Wang et al.
Jingying Pan et al.
Alzheimer's disease (AD) is a debilitating progressively neurodegenerative disease. The best-characterized hallmark of AD, which is marked by behavioral alterations and cognitive deficits, is the aggregation of deposition of amyloid-beta (A...
Changes of brain structure and structural covariance networks in Parkinson's disease associated cognitive impairment [0.03%]
帕金森病认知障碍患者大脑结构及结构协变网络的变化
Rong-Pei Liu,Guo-Liang Lin,Lu-Lu Ma et al.
Rong-Pei Liu et al.
Background: Cognitive impairment (CI) is common in Parkinson's disease (PD). Multiple brain regions and their interactions are involved in PD associated CI. Magnetic resonance imaging (MRI) technology is a non-invasive me...
Ying-Ying Fan,Ruo-Yu Luo,Meng-Tian Wang et al.
Ying-Ying Fan et al.
Delirium is an acute, global cognitive disorder syndrome, also known as acute brain syndrome, characterized by disturbance of attention and awareness and fluctuation of symptoms. Its incidence is high among critically ill patients. Once pat...