Body roundness index and cognitive function in older adults: a nationwide perspective [0.03%]
国人老年人体脂分布与认知功能的关系研究
Feng Zhang,Zhongxing Ning,Can Wang
Feng Zhang
Background: Obesity negatively impacts cognitive function. However, the correlation between the body roundness index (BRI) and cognitive performance remains inadequately explored. ...
Secretase promotes AD progression: simultaneously cleave Notch and APP [0.03%]
γ-分泌酶促进阿尔茨海默病发展：同时切割Notch和APP
Ke-Fan Yang,Jing-Yi Zhang,Mei Feng et al.
Ke-Fan Yang et al.
Alzheimer's disease (AD) involves complex pathological mechanisms. Secretases include membrane protein extracellular structural domain proteases and intramembrane proteases that cleave the topology to type I or type II. Secretases can effec...
Skeletal muscle proteome differs between young APOE3 and APOE4 targeted replacement mice in a sex-dependent manner [0.03%]
APOE4和APOE3定点替换小鼠性别依赖性的骨骼肌蛋白组差异分析
Chelsea N Johnson,Colton R Lysaker,Colin S McCoin et al.
Chelsea N Johnson et al.
Introduction: Apolipoprotein E4 (APOE4) is the strongest genetic risk factor for Alzheimer's disease (AD), yet it's unclear how this allele mediates risk. APOE4 carriers experience reduced mobility and faster decline in m...
The novel estrogen receptor beta agonist EGX358 and APOE genotype influence memory, vasomotor, and anxiety outcomes in an Alzheimer's mouse model [0.03%]
新型雌激素受体β激动剂EGX358和APOE基因型影响阿尔茨海默病小鼠模型的记忆、血管运动和焦虑结果
M R Schwabe,A W Fleischer,R K Kuehn et al.
M R Schwabe et al.
Introduction: Alzheimer's disease (AD) prevalence and severity are associated with increased age, female sex, and apolipoprotein E4 (APOE4) genotype. Although estrogen therapy (ET) effectively reduces symptoms of menopaus...
Corrigendum: Association of trimethylamine oxide and its precursors with cognitive impairment: a systematic review and meta-analysis [0.03%]
更正：三甲胺氧化物及其前体与认知障碍相关性的系统评价和meta分析
Caiyi Long,Zihan Li,Haoyue Feng et al.
Caiyi Long et al.
[This corrects the article DOI: 10.3389/fnagi.2024.1465457.]. Keywords: TMAO; circulating concentration; cog...
Published Erratum
Frontiers in aging neuroscience. 2024 Nov 19:16:1519363. DOI:10.3389/fnagi.2024.1519363 2024
Editorial: APOE4-associated heterogeneity in the pathogenesis of Alzheimer's disease [0.03%]
编辑来稿：载脂蛋白E4与阿尔茨海默病异质性病理的关联性
Eileen Ruth Samson Torres,G William Rebeck,Tal Nuriel
Eileen Ruth Samson Torres
Silymarin administration after cerebral ischemia improves survival of obese mice by increasing cortical BDNF and IGF1 levels [0.03%]
奶蓟素通过增加皮质神经营养因子和胰岛素样生长因子水平来改善肥胖小鼠脑缺血后生存率
Yesica María Rodríguez-Cortés,Ricardo Jair Ramírez-Carreto,Julia Isabel Rodríguez-Barrena et al.
Yesica María Rodríguez-Cortés et al.
Background: Obesity is associated with a systemic inflammatory state that contributes to neuroinflammation and increases the risk of stroke at an early age. Stroke is the third leading cause of death worldwide and the lea...
Reorganized brain functional network topology in stable and progressive mild cognitive impairment [0.03%]
稳定型和进展型轻度认知障碍患者脑功能网络拓扑重构
Chen Xue,Darui Zheng,Yiming Ruan et al.
Chen Xue et al.
Aim: Mild cognitive impairment (MCI) includes two distinct subtypes, namely progressive MCI (pMCI) and stable MCI (sMCI). The objective of this study was to identify the topological reorganization of brain functional netw...
Trajectories of cognitive function and frailty in older adults in China: a longitudinal study [0.03%]
中国老年人认知功能和衰弱的纵向轨迹研究
Xiaoyi Ji,Yue Wu,Zijie Gu et al.
Xiaoyi Ji et al.
Background: Cognitive impairment and frailty are common issues in older adults. Understanding the co-development trajectories of these conditions can provide valuable sights for early detection and intervention in high-ri...
Identification of altered immune cell types and molecular mechanisms in Alzheimer's disease progression by single-cell RNA sequencing [0.03%]
利用单细胞RNA测序识别阿尔茨海默病进展中改变的免疫细胞类型和分子机制
Hua Lin,Li Su,Daniel Mao et al.
Hua Lin et al.
Introduction: Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by gradual loss of cognitive function. Understanding the molecular mechanisms is crucial for developing effective therapies....