The novel estrogen receptor beta agonist EGX358 and APOE genotype influence memory, vasomotor, and anxiety outcomes in an Alzheimer's mouse model [0.03%]
新型雌激素受体β激动剂EGX358和APOE基因型影响阿尔茨海默病小鼠模型的记忆、血管运动和焦虑结果
M R Schwabe,A W Fleischer,R K Kuehn et al.
M R Schwabe et al.
Introduction: Alzheimer's disease (AD) prevalence and severity are associated with increased age, female sex, and apolipoprotein E4 (APOE4) genotype. Although estrogen therapy (ET) effectively reduces symptoms of menopaus...
Corrigendum: Association of trimethylamine oxide and its precursors with cognitive impairment: a systematic review and meta-analysis [0.03%]
更正：三甲胺氧化物及其前体与认知障碍相关性的系统评价和meta分析
Caiyi Long,Zihan Li,Haoyue Feng et al.
Caiyi Long et al.
[This corrects the article DOI: 10.3389/fnagi.2024.1465457.]. Keywords: TMAO; circulating concentration; cog...
Published Erratum
Frontiers in aging neuroscience. 2024 Nov 19:16:1519363. DOI:10.3389/fnagi.2024.1519363 2024
Editorial: APOE4-associated heterogeneity in the pathogenesis of Alzheimer's disease [0.03%]
编辑来稿：载脂蛋白E4与阿尔茨海默病异质性病理的关联性
Eileen Ruth Samson Torres,G William Rebeck,Tal Nuriel
Eileen Ruth Samson Torres
Silymarin administration after cerebral ischemia improves survival of obese mice by increasing cortical BDNF and IGF1 levels [0.03%]
奶蓟素通过增加皮质神经营养因子和胰岛素样生长因子水平来改善肥胖小鼠脑缺血后生存率
Yesica María Rodríguez-Cortés,Ricardo Jair Ramírez-Carreto,Julia Isabel Rodríguez-Barrena et al.
Yesica María Rodríguez-Cortés et al.
Background: Obesity is associated with a systemic inflammatory state that contributes to neuroinflammation and increases the risk of stroke at an early age. Stroke is the third leading cause of death worldwide and the lea...
Reorganized brain functional network topology in stable and progressive mild cognitive impairment [0.03%]
稳定型和进展型轻度认知障碍患者脑功能网络拓扑重构
Chen Xue,Darui Zheng,Yiming Ruan et al.
Chen Xue et al.
Aim: Mild cognitive impairment (MCI) includes two distinct subtypes, namely progressive MCI (pMCI) and stable MCI (sMCI). The objective of this study was to identify the topological reorganization of brain functional netw...
Trajectories of cognitive function and frailty in older adults in China: a longitudinal study [0.03%]
中国老年人认知功能和衰弱的纵向轨迹研究
Xiaoyi Ji,Yue Wu,Zijie Gu et al.
Xiaoyi Ji et al.
Background: Cognitive impairment and frailty are common issues in older adults. Understanding the co-development trajectories of these conditions can provide valuable sights for early detection and intervention in high-ri...
Identification of altered immune cell types and molecular mechanisms in Alzheimer's disease progression by single-cell RNA sequencing [0.03%]
利用单细胞RNA测序识别阿尔茨海默病进展中改变的免疫细胞类型和分子机制
Hua Lin,Li Su,Daniel Mao et al.
Hua Lin et al.
Introduction: Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by gradual loss of cognitive function. Understanding the molecular mechanisms is crucial for developing effective therapies....
The role of serum α-Klotho levels in preventing hearing impairment among middle-aged and older adults: insights from a nationally representative sample [0.03%]
血清α-洛斯霍托蛋白在预防中老年人听力受损中的作用——来自具有全国代表性的调查结果的启示
Siyuan Wang,Wen Sun,Chan Ding et al.
Siyuan Wang et al.
Background: The Klotho gene is implicated in suppressing aging phenotypes and influencing age-related diseases. Previous studies have delved into its connection with different diseases, yet the association between Klotho ...
Association of dementia with the 28-day mortality of sepsis: an observational and Mendelian randomization study [0.03%]
痴呆与脓毒症28天病死率关联的观察性研究和孟德尔随机化研究
Ying Lan,Junchen Zhu,Peng Pu et al.
Ying Lan et al.
Background: Observational research suggests that individuals with dementia who have sepsis face a higher likelihood of death. However, whether there is a causal relationship between the two remains unknown. ...
Effects of traditional Chinese exercises or their integration with medical treatments on cognitive impairment: a network meta-analysis based on randomized controlled trials [0.03%]
基于随机对照试验的网络-meta-分析：传统中医练习或中西医结合治疗对认知障碍的影响
Jiadong Qiu,Sungmin Kim
Jiadong Qiu
Objective: This study aims to summarize and critically evaluate the effects of traditional Chinese exercises, both in isolation and in combination with medical treatments, on cognitive impairment. ...