Research on the innate immune response in transgenic mice following ischemic stroke [0.03%]
缺血性卒中转基因小鼠先天免疫反应的研究进展
Chao Yuan,Yuting Shentu,Qiuhong Ji
Chao Yuan
The high incidence, death, disability, and recurrence of ischemic stroke (CIS) place a significant cost on families and society. According to recent research on the condition, immune-related damage is a major contributor to the development ...
Higher soluble TREM-1 levels are associated with cognitive impairment after acute ischemic stroke [0.03%]
缺血性卒中后可溶性TREM-1水平升高与认知障碍有关
Zhuo Chen,Xin Yi,Wei Fu et al.
Zhuo Chen et al.
Background and purpose: Triggering receptor expressed on myeloid cells-1 (TREM-1) was reported to be critical for mediating the neurological function after stroke, while the impact of soluble TREM-1 (sTREM-1) on cognitive...
Global research trends and hotspots in Parkinson's disease psychosis: a 25-year bibliometric and visual analysis [0.03%]
帕金森病精神病的全球研究趋势和热点：一种25年的引文计量学和可视化分析方法
Jianhong Wu,Xin Jin,Weiming Xie et al.
Jianhong Wu et al.
Background: Parkinson's disease psychosis (PDP) is one of the most severe and disabling non-motor symptoms in the progression of Parkinson's disease (PD), significantly impacting the prognosis of PD patients. In recent ye...
Preliminary reference values for Alzheimer's disease plasma biomarkers in Congolese individuals with and without dementia [0.03%]
刚果痴呆症患者和非痴呆症患者的阿尔茨海默病血浆生物标志物初步参考值
Jean Ikanga,Kharine Jean,Priscilla Medina et al.
Jean Ikanga et al.
Background: Western countries have provided reference values (RV) for Alzheimer's disease (AD) plasma biomarkers, but there are not available in Sub-Saharan African populations. ...
Abnormal eye movements: relationship with clinical symptoms and predictive value for Alzheimer's disease [0.03%]
异常眼动：与临床症状的关系及预测阿尔茨海默病的价值
Jing Qi,Tenghong Lian,Peng Guo et al.
Jing Qi et al.
Background: Abnormal eye movements occur at the early stages of Alzheimer's disease (AD). However, the characteristics of abnormal eye movements of patients with AD and their relationship with clinical symptoms remain inc...
Risk factors analysis of cognitive frailty among geriatric adults in nursing homes based on logistic regression and decision tree modeling [0.03%]
基于逻辑回归和决策树模型的养老机构老年认知脆弱性危险因素分析
Jing Gao,Dingxi Bai,Huan Chen et al.
Jing Gao et al.
Objective: To investigate the risk factors associated with cognitive frailty among older adults in nursing homes using logistic regression and decision tree modeling, and to compare the predictive performance of these met...
Identification of biomarkers in Parkinson's disease by comparative transcriptome analysis and WGCNA highlights the role of oligodendrocyte precursor cells [0.03%]
通过比较转录组分析和WGCNA识别帕金森病生物标志物强调少突胶质细胞前体细胞的作用
Fa-Li Zhang,Ai-Ying Li,Yi-Lin Niu et al.
Fa-Li Zhang et al.
Background: Parkinson's disease (PD) is an age-related neurodegenerative disease characterized by the death of dopamine neurons in the substantia nigra. A large number of studies have focused on dopamine neurons themselve...
Body roundness index and cognitive function in older adults: a nationwide perspective [0.03%]
国人老年人体脂分布与认知功能的关系研究
Feng Zhang,Zhongxing Ning,Can Wang
Feng Zhang
Background: Obesity negatively impacts cognitive function. However, the correlation between the body roundness index (BRI) and cognitive performance remains inadequately explored. ...
Secretase promotes AD progression: simultaneously cleave Notch and APP [0.03%]
γ-分泌酶促进阿尔茨海默病发展：同时切割Notch和APP
Ke-Fan Yang,Jing-Yi Zhang,Mei Feng et al.
Ke-Fan Yang et al.
Alzheimer's disease (AD) involves complex pathological mechanisms. Secretases include membrane protein extracellular structural domain proteases and intramembrane proteases that cleave the topology to type I or type II. Secretases can effec...
Skeletal muscle proteome differs between young APOE3 and APOE4 targeted replacement mice in a sex-dependent manner [0.03%]
APOE4和APOE3定点替换小鼠性别依赖性的骨骼肌蛋白组差异分析
Chelsea N Johnson,Colton R Lysaker,Colin S McCoin et al.
Chelsea N Johnson et al.
Introduction: Apolipoprotein E4 (APOE4) is the strongest genetic risk factor for Alzheimer's disease (AD), yet it's unclear how this allele mediates risk. APOE4 carriers experience reduced mobility and faster decline in m...