Development and internal validation of a nomogram for predicting cognitive impairment after mild ischemic stroke and transient ischemic attack based on cognitive trajectories: a prospective cohort study [0.03%]
基于认知轨迹的轻型缺血性卒中和短暂性脑缺血发作后认知障碍预测列线图的开发与内部验证：前瞻性队列研究
Panpan Zhao,Lin Shi,Guimei Zhang et al.
Panpan Zhao et al.
Introduction: Many predictive models for cognitive impairment after mild stroke and transient ischemic attack are based on cognitive scales at a certain timepoint. We aimed to develop two easy-to-use predictive models bas...
Multi-functional role of apolipoprotein E in neurodegenerative diseases [0.03%]
载脂蛋白E在神经退行性疾病中的多重作用功能
Sadequl Islam,Arshad Noorani,Yang Sun et al.
Sadequl Islam et al.
Genetic diversity in the apolipoprotein E (ApoE) gene has been identified as the major susceptibility genetic risk factor for sporadic Alzheimer's disease (SAD). Specifically, the ApoEε4 allele is a significant risk factor for SAD, while A...
From hypoxic pockets to daily routines: linking brain oxygenation and cognitive resilience [0.03%]
从缺氧斑点到日常活动：连接大脑氧合与认知韧性
Dian Jiao
Dian Jiao
The discovery of hypoxic pockets within the cortical regions has transformed the understanding of cerebral oxygen dynamics, revealing their dual role as both contributors to neuronal adaptation and potential precursors to dysfunction. These...
Hypertension moderates the relationship between plasma beta-amyloid and cognitive impairment: a cross-sectional study in Xi'an, China [0.03%]
高血压通过血浆β淀粉样蛋白与认知障碍关系的中介作用：中国西安的一项横断面研究
Ziyu Liu,Yaoli He,Simeng Cui et al.
Ziyu Liu et al.
Background: Plasma beta-amyloid (Aβ) are important biomarkers for Alzheimer's disease and cognitive impairment (CI), but results are controversial. It remains unclear whether hypertension modulates their relationship. Th...
Untargeted urine metabolomics reveals dynamic metabolic differences and key biomarkers across different stages of Alzheimer's disease [0.03%]
非目标尿液代谢组学揭示阿尔茨海默病不同阶段的动态代谢差异和关键生物标志物
Xiaoya Feng,Shenglan Zhao
Xiaoya Feng
Background: Alzheimer's disease (AD) is a progressive neurodegenerative disorder, with mild cognitive impairment (MCI) often serving as its precursor stage. Early intervention at the MCI stage can significantly delay AD o...
Mapping hippocampal glutamate in healthy aging with in vivo glutamate-weighted CEST (GluCEST) imaging [0.03%]
利用谷氨酸加权CEST（GluCEST）成像技术在健康老龄化中绘制海马体谷氨酸分布地图
Maggie K Pecsok,Heather Robinson,Ally Atkins et al.
Maggie K Pecsok et al.
Introduction: Hippocampal glutamate (Glu) dysfunction is a pertinent indicator of neurodegeneration, yet mapping typical age-related changes in Glu has been challenging. Here, we use a 7T MRI approach, Glutamate Chemical ...
Baseline liver fibrosis-4 score correlates to the progression of anxiety and cognitive impairment in patients with Parkinson's disease [0.03%]
基线肝脏纤维化-4评分与帕金森病患者焦虑和认知障碍进展的相关性
Yongqing Cheng,Li Chen,Honghong Zhu et al.
Yongqing Cheng et al.
Background: Non-alcoholic fatty liver disease (NAFLD) or liver fibrosis may share similar pathophysiological features with Parkinson's disease (PD), yet their correlation was unclear. This study aimed to explore their cor...
Diagnostic potential of urinary CX3CL1 for amnestic mild cognitive impairment and Alzheimer's disease [0.03%]
尿液CX3CL1诊断血管性认知障碍和阿尔茨海默病的潜力
Yali Xu,Jie Zhang,Ying-Ying Shen et al.
Yali Xu et al.
Introduction: The role of the chemokine CX3CL1 in the processes of aging and Alzheimer's disease (AD) pathogenesis is well-established. This study aims to evaluate the diagnostic potential of urinary CX3CL1 levels in dist...
Aging restricts the initial neural patterning potential of developing neural stem and progenitor cells in the adult brain [0.03%]
衰老限制了大脑中发育神经干细胞和祖细胞的初始神经模式化潜能
Saeideh Aran,Mohammad Ghasem Golmohammadi,Mohsen Sagha et al.
Saeideh Aran et al.
Introduction: Neurosphere culture is widely used to expand neural stem and progenitor cells (NSPCs) of the nervous system. Understanding the identity of NSPCs, such as the principals involved in spatiotemporal patterning,...
Lingguizhugan decoction enhances autophagy of Alzheimer's disease via regulating the mTOR/ p70s6K pathway in vivo and in vitro [0.03%]
苓桂术甘汤通过调控mTOR/p70S6K信号通路改善阿尔茨海默病小鼠模型的自噬作用的体内及体外研究
Xiaojing Chen,Qingrong Tian,Min Gao et al.
Xiaojing Chen et al.
Introduction: Lingguizhugan decoction (LGZG) has been reported to treat Alzheimer's disease (AD) by anti-inflammatory and transporting amyloid-β (Aβ). M...