Volumetric signatures of basal ganglia-thalamo-cortical and cerebello-thalamo-cortical networks in Parkinson's disease and its motor subtypes [0.03%]
帕金森病及其运动亚型的纹状体-丘脑-皮层和小脑-丘脑-皮层网络的体积标志物
Fatemeh Sadeghi,Abdullah Okar,Ronak Rashedi et al.
Fatemeh Sadeghi et al.
Introduction: Parkinson's disease (PD) is a systems-level disorder, implicating basal ganglia-thalamo-cortical (BTC) and cerebello-thalamo-cortical (CTC) networks. While regional atrophy has been reported, network-wide vo...
Focused ultrasound enhances targeted curcumin delivery and alleviates behavioral and neuropathological deficits in a Parkinson's disease mouse model [0.03%]
聚焦超声增强靶向姜黄素递送并缓解帕金森病小鼠模型的行为和神经病理缺陷
Shu-Mei Yang,Sen-Hi Yeoh,Meng-Ting Lin et al.
Shu-Mei Yang et al.
Introduction: Curcumin exhibits potent neuroprotective properties but is limited by poor blood-brain barrier (BBB) permeability. This study aimed to evaluate whether focused ultrasound (FUS)-mediated BBB opening enhances ...
Katherine M Andersh,Michael MacLean,Gareth R Howell et al.
Katherine M Andersh et al.
Introduction: A growing body of literature suggests a role for neuroinflammation in retinal ganglion cell (RGC) death in glaucoma. For instance, deficiency of three proinflammatory cytokines, complement component 1, subco...
Multimodal neuroimaging discrimination of Alzheimer's disease, mild cognitive impairment, and late-life depression using electroencephalography and functional near-infrared spectroscopy: integrating electrophysiological and hemodynamic biomarkers [0.03%]
结合脑电生理和血氧生物标志物的阿尔茨海默病、轻度认知障碍和晚发抑郁的多模态神经影像学鉴别诊断：基于脑电图和功能性近红外光谱技术
Xi Mei,Ming Liang,Nairong Ruan et al.
Xi Mei et al.
Objective: To identify electrophysiological and hemodynamic characteristics of the cerebral cortex during the resting-state that could help differentiate Alzheimer's disease (AD), mild cognitive impairment (MCI), and late...
Physical exercise/melatonin interaction in young rats fed a low-protein diet: a behavioral, electrophysiological, and redox balance analysis [0.03%]
低蛋白饮食大鼠运动与褪黑素交互作用的的行为、电生理和氧化损伤研究
Maria Luísa Figueira de Oliveira,Jennyfer Martins de Carvalho,José Anderson da Silva Gomes et al.
Maria Luísa Figueira de Oliveira et al.
Introduction: Early-life protein malnutrition disrupts redox balance in the brain and alters brain development and function. This study evaluated the effects of subcutaneous melatonin (MLT) administration, treadmill exerc...
Understanding illness awareness in Alzheimer's disease: a qualitative study with patient-caregiver dyads in Colombia [0.03%]
阿尔茨海默病患者的患病意识：哥伦比亚患者-照料者双人组的定性研究
Claudia Ramos,Claudia Madrigal,Jenny García et al.
Claudia Ramos et al.
Background: Diminished awareness of illness is a frequent neuropsychiatric symptom in people with Alzheimer's disease. It has been linked to emotional and behavioral challenges such as depression, apathy, irritability, an...
Medial prefrontal activation as a neural predictor of cognitive training gains in older adults with amnestic mild cognitive impairment: exploratory evidence [0.03%]
背外侧前额叶激活作为预测遗忘性轻度认知障碍老年人认知训练获益的神经标志：探索性研究证据
Soowon Park,Yeeun Byeon,Jung-In Lim et al.
Soowon Park et al.
Background: Not all individuals benefit equally from cognitive training, making it essential to identify neural markers that can predict individual responsiveness, particularly among those at the early stages of cognitive...
Neuromelanin, iron and MRI measurements in midbrain tissues of Parkinson's and Alzheimer's subjects [0.03%]
黑质多巴胺能神经元衰老相关的神经原纤维缠结和路易小体及其与帕金森病和阿尔茨海默病的关系研究
Fabio A Zucca,Clifford M Cassidy,Michela Sturini et al.
Fabio A Zucca et al.
Background: In Parkinson's disease, decreased neuromelanin and increased Fe concentrations derive from the loss of neuromelanin-containing neurons in the substantia nigra, which is spared in Alzheimer's disease. We aimed ...
Forecasting individualized progression of Alzheimer's disease using structural MRI and population spatiotemporal priors [0.03%]
基于结构磁共振影像和时空先验的阿尔茨海默病个体化进展预测
Yan Zhao,Tongtong Che,Xiuying Wang et al.
Yan Zhao et al.
Objective: Alzheimer's disease (AD), the most common neurodegenerative disorder, involves the progressive loss of vulnerable neurons. Tracking its progression via structural magnetic resonance imaging (sMRI), which captur...
Changes in the brain [NAD+]/[NADH] and [NADPH]/[NADP+] with aging and anti-aging dietary restriction [0.03%]
与衰老及抗衰老的饮食限制相关的脑[NAD+]/[NADH]和[NADPH]/[NADP+]比值变化
Leah E Jamerson,Tara D Bradshaw,Patrick C Bradshaw
Leah E Jamerson
Changes in brain [NADPH]/[NADP+] and [NAD+]/[NADH] may contribute to aging. Anti-aging dietary restriction (DR) and intermittent fasting (IF) alter redox states that may contribute to their longevity effects. Pyruvate/lactate and acetoaceta...