Klotho deficiency and cognitive impairment in dialysis patients: mechanisms, clinical evidence, and therapeutic implications [0.03%]
克洛托缺乏与透析患者的认知功能障碍：机制、临床证据和治疗意义
Weiwei Hu,Yuke Kong,Jianqin Wang
Weiwei Hu
Cognitive impairment is highly prevalent among patients with end-stage renal disease (ESRD), particularly those undergoing dialysis, and is associated with poor clinical outcomes and reduced quality of life. Emerging evidence suggests that ...
Interpretable machine learning models for identifying cognitive impairment in middle-aged and older adults with mild and severe insomnia: development, temporal validation, and clinical external validation [0.03%]
可解释的机器学习模型在识别中老年人轻度和重度失眠相关认知障碍中的开发、时效性验证及临床外部验证研究
Qilong Wang,Siheng Ma,Jianpeng Zhao et al.
Qilong Wang et al.
Background: Cognitive impairment is an important health issue in middle-aged and older adults, and insomnia may be associated with increased cognitive vulnerability. However, models specifically designed to identify cogni...
Depressive symptoms and multiple markers of brain aging in community-dwelling older adults [0.03%]
社区老年人的抑郁症状和多种大脑衰老标志物的相关性研究
Jea Chul Ha,Jiyoun Jung,Yu-Mi Kim et al.
Jea Chul Ha et al.
Late-life depressive symptoms have been associated with structural brain changes and cognitive impairment, but prior studies have typically examined individual markers of brain aging in isolation. This study examined the associations betwee...
Peripheral metabolomic profiling reveals lipid and amino acid alterations associated with immuno-inflammatory responses in treatment-naïve late-onset Alzheimer's disease [0.03%]
外周代谢组学谱分析揭示治疗初晚发型阿尔茨海默病患者免疫炎症反应相关的脂质及氨基酸改变
Pei-Juan Wang,Xiao-Yu Yang,Lei Ji et al.
Pei-Juan Wang et al.
Background: Immuno-metabolic dysregulation contributes to Alzheimer's disease (AD) pathogenesis, yet the peripheral metabolic landscape and its interplay with neuroinflammation remain poorly characterized in treatment-na...
The predictive power of neuropsychological measures in MCI: early detection of dementia conversion [0.03%]
神经心理测量在MCI中预测痴呆转化的价值：痴呆早期诊断
Concepcion Padilla,Sara E Zsadanyi,Irina Aragón et al.
Concepcion Padilla et al.
Background: With rising global life expectancy, early identification of dementia risk is crucial for implementing timely interventions. This study assesses the value of neuropsychological measures in stratifying the risk ...
Age-associated neuronal micronuclei formation and transfer to microglia [0.03%]
年龄相关的神经元微核形成及向小胶质细胞的转移
Chihiro Maeda,Yusuke Kishi,Ikuko Takeda et al.
Chihiro Maeda et al.
Microglia, the resident immune cells of the central nervous system, dynamically respond to signals from their microenvironment, including adjacent neurons. Among these signals, nuclear contents released from damaged neurons have been implic...
Ershiwuwei Shanhu Pill ameliorates cognitive impairment in Alzheimer's disease mice by remodeling gut microbiota and host serum metabolites [0.03%]
二十五味山花丸通过重塑阿尔茨海默病小鼠肠道菌群及宿主血清代谢物改善认知障碍
Ning Li,Kunxia Jiang,Xiaoyuan Peng et al.
Ning Li et al.
Alzheimer's disease (AD), with the most prominent pathological feature of the accumulation of amyloid-beta (Aβ) plaques and neurofibrillary tangles of hyperphosphorylated tau proteins (P-tau), is the foremost cause of dementia. Ershiwuwei ...
Behind the scenes of a 7T MRI clinical study in Alzheimer's disease: challenges and recommendations for future research [0.03%]
7特斯拉磁共振成像在阿尔茨海默病临床研究中的应用：挑战和对未来研究的建议
Maria Dobrushina,Friedrich Krohn,Sayyeda Chandni et al.
Maria Dobrushina et al.
Combining pharmacological interventions with neuroimaging in Alzheimer's disease (AD) research presents logistical and methodological challengesparticularly during early study phases, such as recruitment and study visits. Yet, these challen...
Striatal functional connectivity alterations in mild cognitive impairment subtypes defined by CSF A/T biomarkers [0.03%]
基于脑脊液A/T标志物定义的轻度认知障碍亚型的纹状体功能连接改变
Yue Tang,Yiming Ruan,Darui Zheng et al.
Yue Tang et al.
Background: Mild cognitive impairment (MCI) is the prodromal stage of Alzheimer's disease (AD), the primary cause of dementia. In addition to supporting motor and higher-order cognitive activities, the basal ganglia, part...
State sensitivity and five-year longitudinal stability of resting-state EEG biomarker candidates in healthy adults [0.03%]
健康成年人休息状态EEG生物标志候选人五年纵向稳定性及状态敏感性研究
Ye-Ji Park,Beom-Jin Kwon,Hoo-Joon Lee et al.
Ye-Ji Park et al.
Resting-state EEG is widely used to investigate individual differences in brain function, as it allows repeated measurements with high temporal resolution and minimal task demands. However, validating EEG metrics as biomarker candidates req...