The differential expression profiles of miRNA in serum-derived exosomes and its potential role in age-related hearing loss [0.03%]
来自血液外泌体的miRNA差异表达谱及其在年龄相关听力损失中的潜在作用
Juhong Zhang,Haizhu Ma,Jing Ke et al.
Juhong Zhang et al.
Objectives: This study aimed to characterize serum exosomal miRNA profiles from patients with age-related hearing loss (ARHL) to identify key pathogenesis-related miRNAs for ARHL. ...
The aggregate proteome of Caenorhabditis elegans mitochondria implicates shared mechanisms of aging and Alzheimer's disease [0.03%]
秀丽隐杆线虫线粒体蛋白组的汇编揭示了衰老和阿尔茨海默病之间的共同机制
Sonu Pahal,Akshatha Ganne,Meenakshisundaram Balasubramaniam et al.
Sonu Pahal et al.
Background: Mitochondrial dysfunction and protein aggregation are central features of brain aging and Alzheimer's disease (AD). To define how AD seed proteins modulate these processes, we applied quantitative proteomics t...
Research trends and frontiers of astrocytes in cognitive impairment: a bibliometric analysis from 2015 to 2024 [0.03%]
2015—2024年星形胶质细胞在认知障碍领域研究趋势和前沿的计量学分析
Zhilin Huang,Wanting Liu,Yating Zhang et al.
Zhilin Huang et al.
Objective: Astrocytes, constituting the predominant glial cell population with in the central nervous system, have emerged as a focal point of investigation due to their multifaceted roles and therapeutic implications in ...
Correlation between blood biomarkers and post-stroke cognitive impairment [0.03%]
血浆生物标志物与脑卒中后认知障碍的关系分析
Xianjun Liu,Zhaoyang Lv,Zhihong Shi et al.
Xianjun Liu et al.
Background: Post-stroke cognitive impairment (PSCI) is common and imposes a significant burden upon both families and society. There is limited information on biomarkers for PSCI. This study investigated the correlation b...
Autophagy-mediated regulation of neutrophil inflammatory responses and its relevance to central nervous system diseases [0.03%]
自噬介导的中性粒细胞炎症反应调节及其中枢神经系统疾病中的作用
Yuliu Li,Yiqing Tan,Wei Zuo
Yuliu Li
Autophagy is an intracellular degradation system, which plays a crucial role in regulating the inflammatory functions of neutrophils. Neutrophils, as crucial immunological phagocytes, are integral to inflammatory responses. In central nervo...
The olfactory functional network in the Alzheimer's disease continuum: a resting state fMRI study [0.03%]
阿尔茨海默病连续谱中的嗅觉功能网络：一项静息态fMRI研究
Daniela Ballotta,Claudia Casadio,Manuela Tondelli et al.
Daniela Ballotta et al.
Introduction: Olfactory dysfunction is common in the Alzheimer's Disease continuum, and olfaction may be altered before clinical syndrome onset. The present study aimed at investigating the functional connectivity of the ...
Influence of anesthetic agent and burst suppression on postoperative delirium in elderly patients: a prospective cohort study with automated EEG analysis [0.03%]
麻醉药物和爆破抑制对老年患者术后谵妄的影响：一项具有自动脑电图分析的前瞻性队列研究
Maximilian Markus,Marc Dorenbeck,Vera Röhr et al.
Maximilian Markus et al.
Background: Guidelines currently suggest considering EEG guidance during general anesthesia in elderly patients to avoid prolonged burst suppression (BS), with the aim of mitigating postoperative delirium (POD). Our study...
Machine learning-guided analysis of metabolomic alterations in Parkinson's disease with comorbid symptoms [0.03%]
机器学习指导的帕金森病合并症代谢组学改变分析
Ran Sun,Lin Wang,Yanli Wang et al.
Ran Sun et al.
Introduction: As a common neurodegenerative disorder, Parkinson's disease (PD) primarily affects dopaminergic neurons, leading to progressive motor disabilities along with a spectrum of non-motor complications. The early ...
The top 100 cited articles on artificial intelligence in Alzheimer's disease and mild cognitive impairment: a bibliometric analysis [0.03%]
被引用次数最高的关于人工智能在阿尔茨海默病和轻度认知障碍研究的前100篇文章：文献计量分析
Zhi Tao,Rui Zhou,Yinggang Zheng et al.
Zhi Tao et al.
Background: Alzheimer's disease (AD) and Mild Cognitive Impairment (MCI) pose significant societal and healthcare burden. Artificial intelligence (AI) methods have been widely applied in AD and MCI studies. We conducted a...
A 24-week multi-component exercise program improves cognition and body composition in older adults with mild cognitive impairment: a randomized controlled trial [0.03%]
一种多成分运动方案能够改善轻度认知功能障碍老年人的认知功能和身体组成：随机对照试验
Danming Xu,Xiaochu Wu,Junming Dai et al.
Danming Xu et al.
Background: This study investigated whether a 24-week, community-based multicomponent exercise intervention (MCEI) can improve body composition and cognitive function in older adults with mild cognitive impairment (MCI). ...