Lower hippocampal volume partly mediates the association between rs6859 in the NECTIN2 gene and Alzheimer's disease: new findings from causal mediation analysis of ADNI data [0.03%]
较低的海马体体积部分介导了NECTIN2基因rs6859多态性与阿尔茨海默病之间的关联：来自ADNI数据的因果中介分析新发现
Aravind Lathika Rajendrakumar,Konstantin G Arbeev,Olivia Bagley et al.
Aravind Lathika Rajendrakumar et al.
Introduction: Alzheimer's disease (AD) is a complex disorder influenced by many factors. The rs6859 polymorphism in the NECTIN2 gene has been consistently linked to AD risk. The NECTIN2 is involved in vulnerability to inf...
Brain lipidomics for region-specific biomarker discovery in neurodegenerative diseases [0.03%]
脑脂质组学在神经退行性疾病区域特异性生物标志物发现中的应用
Jayashankar Jayaprakash,Solomon Tebeje Gizaw,Divyavani Gowda et al.
Jayashankar Jayaprakash et al.
Background: Alzheimer's disease (AD), Parkinson's disease (PD), and Huntington's disease (HD) are progressive neurodegenerative diseases (NDs) characterized by chronic neuronal loss. The lack of effective treatments highl...
Cortical hemodynamic responses in older stroke patients during a walking-based Stroop dual task: a functional near-infrared spectroscopy study [0.03%]
功能性近红外光谱学在行走stroop双重任务中老年卒中患者皮层血流动力学反应中的应用研究
Xiaohan Li,Kai Tang,Yuting Zhang et al.
Xiaohan Li et al.
Objectives: This study aimed to investigate cortical hemodynamic responses in older stroke patients during a walking-based Stroop dual task using functional near-infrared spectroscopy (fNIRS). ...
Oxytocin restores cognitive function and attenuates neuroinflammation in chronic sleep-deprived aged rats [0.03%]
催产素可通过恢复认知功能和减轻慢性睡眠剥夺引起的小胶质细胞活化改善老年大鼠的认知衰退症状
Hany A Elkattawy,Mohamed El-Sherbiny,Nehal Elsherbiny et al.
Hany A Elkattawy et al.
Background: Sleep is a fundamental biological process essential for maintaining mental, emotional, and physical health. Chronic sleep deprivation (SD), particularly in aging, is associated with oxidative stress, neuroinfl...
Mechanistic modeling of amyloid dynamics relating to Alzheimer's disease progression [0.03%]
与阿尔茨海默病进展相关的淀粉样蛋白动力学机制建模
Andrzej Przekwas,Carly Norris,Harsha T Garimella
Andrzej Przekwas
The use of mechanistic models to support personalized medicine and precision diagnostics offers transformative potential for neurology. In this study, we developed a mechanistic model of Alzheimer's Disease progression (mAD) that integrates...
APOE genotypes are associated with the level of naturally occurring antibodies to amyloid- β in patients with Alzheimer's disease [0.03%]
APOE基因型与阿尔茨海默病患者天然产生的淀粉样蛋白β抗体水平有关
Janardan P Pandey,Aryan M Namboodiri,Franca Rosa Guerini et al.
Janardan P Pandey et al.
Apolipoprotein E ε4 (APOEε4) allele is the strongest known genetic risk factor for Alzheimer's disease (AD). Mechanisms underlying this association are incompletely understood. We aimed to determine whether APOE genotypes influenced the l...
ZCCHC17: a target for synaptic dysfunction and neuronal excitability in Alzheimer's disease [0.03%]
阿尔茨海默病中ZCCHC17的突变导致突触功能障碍及神经元兴奋性异常
Brittany A Klub,Andrew F Teich,Giuseppe P Cortese
Brittany A Klub
Epileptic activity and neuronal excitability have been reported in the setting of Alzheimer's disease (AD), and may be linked to disease progression and severity. A shift in the excitation/inhibition balance to favor a more excitatory-domin...
Potential protein blood-based biomarkers for cognitive dysfunction in Parkinson's disease: a systematic review and network meta-analysis [0.03%]
潜在的蛋白质血液生物标志物可用于帕金森病的认知障碍：系统评价和网络meta分析
Youxue Tu,Changmei Lu,Bao Wu et al.
Youxue Tu et al.
Objectives: Parkinson's disease (PD) patients frequently develop mild cognitive impairment (PD-MCI) and may progress to Parkinson's disease dementia (PDD). Despite progress in understanding PD pathophysiology, reliable bl...
Astaxanthin as a neuroprotective modulator of synaptic plasticity, learning, and memory: mechanistic insights and therapeutic perspectives in neurodegenerative aging [0.03%]
虾青素作为调节突触可塑性、学习和记忆的神经保护调节因子：在神经退行性衰老中的机制见解和治疗前景
Fan Guo,Jiapei Chi
Fan Guo
Astaxanthin (AST), a xanthophyll carotenoid derived from microalgae and marine organisms, has emerged as a potent neuroprotective compound with remarkable antioxidant and anti-inflammatory properties. Growing evidence indicates that AST can...
Neural correlates of prospective memory in Parkinson's disease: a high-density EEG study [0.03%]
帕金森病前瞻性记忆的神经相关性：一次高密度脑电图研究
Paola Santacesaria,Stefano Vicentin,Giorgia Cona
Paola Santacesaria
Introduction: Prospective memory (PM), the ability to remember and execute intended actions in the future, is a critical component of daily functioning and independent living, particularly in individuals with Parkinson's ...