Regional brain and cerebrovasculature morphology during normative aging in male and female C57BL/6N mice [0.03%]
雄性和雌性C57BL/6N小鼠在正常衰老过程中脑部和脑血管形态的改变
Amandine Jullienne,Tannoz Norouzi,Erik J Behringer et al.
Amandine Jullienne et al.
Introduction: Normative aging is the process of gradual physical, cognitive and biological changes that occur with advancing age. This contrasts to pathological processes, such as neurodegeneration where changes are accel...
Trajectories and timing of accelerated decline in specific memory domains preceding Alzheimer's disease [0.03%]
阿尔茨海默病前特定记忆领域加速下降的时间和轨迹
Xianxian Long,Meng Rong,Shushu Long et al.
Xianxian Long et al.
Introduction: Memory impairment is a hallmark feature of Alzheimer's disease (AD) and may emerge years before clinical diagnosis. However, the temporal sequence and acceleration patterns of decline across specific memory ...
Mechanisms and disease associations of oxidative stress-mediated brain-bone axis dysregulation: a knowledge mapping and trend analysis based on Bibliometrics [0.03%]
基于文献计量学的知识图谱和趋势分析揭示氧化应激介导的脑骨轴紊乱的机制及其相关疾病
Hao Zeng,Zhengpeng Li,Siyuan Jiang et al.
Hao Zeng et al.
Background: Oxidative stress, characterized by the systemic imbalance between reactive oxygen species and antioxidant defenses, is increasingly recognized as a central pathological nexus driving the dysregulation of the b...
Selective amygdala subregional atrophy in Parkinson's disease: from subjective cognitive decline to mild cognitive impairment [0.03%]
帕金森病从主观认知下降到轻度认知障碍的杏仁核亚区域选择性萎缩
Liujia Lu,Binfen Xu,Yi Ji et al.
Liujia Lu et al.
Background: Cognitive impairment is a common and disabling non-motor feature of Parkinson's disease (PD). Subjective cognitive decline (SCD) has been proposed as an early clinical stage of cognitive dysfunction in PD; how...
Aerobic exercise interventions for older adults with cognitive frailty: a systematic review [0.03%]
老年人认知脆弱性人群有氧运动干预措施的系统评价
Xu Zhou,Lin Chen,Zheng Huang et al.
Xu Zhou et al.
Objective: The purpose of this study was to systematically review the effects of aerobic exercise on cognitive function in older adults using randomized controlled trials (RCTs). ...
Beyond grip strength: selective slowing of grip force release but not initiation dynamics in a go/no-go target force-matching task [0.03%]
握力之外：在目标力量匹配任务中选择性地减慢握力释放但不是启动动力学的减速现象
Syed Qadri,Jose Roberto Torres Andrade,Seraphina Culp et al.
Syed Qadri et al.
Introduction: Precise regulation of grip forces is fundamental for skilled object manipulation and independent navigation of everyday activities throughout the lifespan. Maximal grip strength is a widely used biomarker of...
Rethinking PINK1/Parkin-mediated mitophagy in Parkinson's disease: functional continuity and activation-clearance uncoupling [0.03%]
帕金森病中PINK1/Parkin介导的线粒体自噬的新思考：功能连续性与激活-清除脱钩
Lingzhe Wang,Bin Xu
Lingzhe Wang
Mitochondrial dysfunction is a central feature of Parkinson's disease (PD) and contributes to the selective vulnerability of nigral dopaminergic (DA) neurons. Among the pathways that maintain mitochondrial integrity, PINK1/Parkin-mediated m...
ZBTB7A-mediated regulation of astrocytic glycolysis in neurodegenerative diseases: insights from literature review and bioinformatics prediction [0.03%]
锌指转录因子ZBTB7A介导的星形胶质细胞糖酵解在神经退行性疾病中的调节：文献回顾和生物信息学预测的新见解
Ping Ye,Zhen Li,Xingang Cui et al.
Ping Ye et al.
The incidence of neurodegenerative diseases, including Alzheimer's disease (AD), continues to increase with the extension of human lifespan. However, their pathogenesis remains incompletely understood. Altered energy metabolism, particularl...
Non-invasive brain stimulation in frontotemporal dementia: syndrome-specific signals and priorities for future trials [0.03%]
非侵入性脑刺激在额颞叶痴呆中的作用：综合征特异性信号及未来试验的优先事项
Jingshu Wang,Xiaoshu Fu,Jiangru Liu et al.
Jingshu Wang et al.
Frontotemporal dementia is the second most common cause of young-onset dementia after Alzheimer's disease and lacks disease-modifying treatment. This narrative review summarizes human studies of non-invasive brain stimulation, including rep...
Exercise and neural circuit stability in early Alzheimer's disease: evidence across memory, executive, cholinergic, and circadian systems [0.03%]
运动与阿尔茨海默病早期神经环路的稳定性：记忆、执行功能、胆碱能和昼夜节律系统的证据
Qing Li,Mingchen Gu,Wei Li
Qing Li
Early Alzheimer's disease (AD) is increasingly understood as a phase in which neural circuit dysfunction emerges alongside molecular pathology and local neuronal injury. Although physical exercise has been linked to a deceleration in cognit...