Age-related decline in temporal sound processing: insights from envelope steepness map in the mouse auditory cortex [0.03%]
与年龄相关的瞬态声处理能力下降：来自小鼠听皮层包络陡度图的启示
Tianrui Guo,Kuniyuki Takahashi,Shinsuke Ohshima et al.
Tianrui Guo et al.
Introduction: Spectral information of speech sounds is spatially arranged from low to high frequencies in the auditory cortex, known as tonotopic maps. Recently, we identified an envelope steepness map encoding the rise-r...
Association between frailty and cognitive impairment in elderly patients with acute cerebral infarction [0.03%]
脆弱性与急性脑梗死老年患者认知障碍的相关性研究
Xiangjun Tao,Ying Wang,Shu Ding
Xiangjun Tao
Background: Post-stroke cognitive impairment is common in older patients, yet the interaction between frailty and cognition remains insufficiently characterized. Evidence using multidimensional frailty tools during hospit...
Toward an understanding of real-world mobility in Parkinson's: insights from enhanced contextualisation using GPS-derived location and data-driven modeling of walking speed [0.03%]
利用GPS获取的位置和步行速度数据驱动模型增进对帕金森病患者实际移动能力理解的见解
Cameron Kirk,Rana Zia Ur Rehman,Brook Galna et al.
Cameron Kirk et al.
Introduction: Conventional clinical assessments do not fully capture how Parkinson's disease (PD) affects mobility in daily life. Integrating digital mobility outcomes (DMOs) from wearable devices with GPS-derived context...
The genetic architecture of Parkinson's disease in Mexico: a systematic review [0.03%]
墨西哥帕金森病的遗传结构：系统性综述
Oscar Arias-Carrión,Elizabeth Romero-Gutiérrez,Francisco X Castellanos-Juárez et al.
Oscar Arias-Carrión et al.
Background: Despite substantial advances in Parkinson's disease genomics, Latin American populations remain underrepresented in global genetic studies, limiting the generalizability of risk estimates and biological infere...
Insulin resistance (TyG index) and body mass index as metabolic biomarker combined with ApoE genotype to diagnose Alzheimer's disease [0.03%]
胰岛素抵抗（TyG指数）和体重指数作为代谢生物标志物结合ApoE基因型诊断阿尔茨海默病
Renyu Chen,Shiyu Fan,Cihan Di et al.
Renyu Chen et al.
Background: Growing evidence suggests that both ApoE genotype and metabolic disturbances including insulin resistance (IR) and obesity constitute risk factors for Alzheimer's disease (AD). However, large-scale studies inv...
Systems-level molecular and immunological evidence identifies Th17/Treg modulation as a key mechanism of CRSJ's neuroprotection in Parkinson's disease [0.03%]
系统水平的分子和免疫学证据识别出Th17/Treg调节作为CRSJ在帕金森病中神经保护的关键机制
Xun Li,XiYu Li,ShiYa Chen et al.
Xun Li et al.
Background: Parkinson's disease (PD) is a progressive neurodegenerative disorder in which neuroinflammation plays a central role. Congrong Shujing Granules (CRSJ), a traditional Chinese medicine formula, have shown clinic...
Development and validation of a clinical prediction model for first fall in early Parkinson's disease: a study of two fall-naive cohorts [0.03%]
帕金森病早期首次跌倒的临床预测模型的开发和验证：两项无跌倒史队列的研究
Yu Wang,Jianing Mei,Yunzhe Tang et al.
Yu Wang et al.
Background: Falls are frequent and debilitating complications in Parkinson's disease (PD), with a substantial risk present even in early stages. Predicting the first fall is critical for preventive interventions, yet exis...
Putative sympathetic-predominant subtype in body-first Parkinson's disease is associated with accelerated cognitive decline [0.03%]
身体先发帕金森病中交感神经占优势的亚型与加速的认知衰退相关
Xining Liu,Zhiheng Xu,Xiuyuan Li et al.
Xining Liu et al.
Background: Parkinson's disease (PD) can be classified into brain-first and body-first subtypes based on the initial site of α-synuclein pathology. Postmortem studies further suggest that body-first PD may be divided int...
Behavioral deficits and exacerbated neural and hemodynamic odor responses during lifespan of a mouse model of late onset Alzheimer's disease expressing humanized APOEε4 and Trem2*R47H [0.03%]
表达人类化APOEε4和Trem2*R47H小鼠模型在生命期的行为缺陷及神经与血氧水平的功能磁共振成像异常增强的气味反应
Misha Izydorczak,Maggie Oumov,Mansiben V Udhwani et al.
Misha Izydorczak et al.
Alzheimer's disease (AD) poses a significant global health challenge, being the most prominent cause of dementia with prevalence increasing as the population ages. While the majority of AD cases are late-onset (LOAD), current animal models ...
Association between end-tidal sevoflurane concentration and postoperative cognitive dysfunction and pain sensitivity in elderly patients under general anesthesia [0.03%]
吸入维持全麻的老年人术后认知功能障碍与疼痛敏感性与呼末七氟醚浓度相关性研究
Yunyun Zhou,Han Zheng,Zhengyu Li et al.
Yunyun Zhou et al.
Objective: To analyze the association between end-tidal sevoflurane concentration and postoperative cognitive dysfunction (POCD) and pain sensitivity in elderly patients under general anesthesia. ...