Artificial intelligence and multi-omics nominate TAZ as an insomnia-related diagnostic and druggable target for Parkinson's disease patients [0.03%]
人工智能与多组学鉴定TAZ为帕金森病失眠相关诊断和药物靶点
Wenjing Ma
Wenjing Ma
Background: Insomnia is one of the most common non-motor comorbidities of Parkinson's disease (PD) and often before the onset of motor symptoms. Identifying the molecular mechanisms of insomnia may facilitate the early di...
Spinal glial cell derived extra-pituitary prolactin contributes to postoperative pain in females [0.03%]
脊髓胶质细胞源性的非垂体催乳素参与女性术后痛觉过敏形成
Mayur J Patil,Sergei Belugin,Michael Henry et al.
Mayur J Patil et al.
Peripheral and spinal prolactin (PRL) receptor (PRLR) signaling contributes to the female-selective regulation of pain. This study investigated the relative roles of pituitary-derived PRL (PRLpit) and extra-pituitary PRL (PRLext) in these e...
Which aspects of the everyday behavior of older dogs correlate with performance on a visuo-spatial memory test and the canine cognitive dysfunction rating scale (CCDR)? [0.03%]
年老犬的日常行为与视空间记忆测试和犬认知功能障碍评价量表（CCDR）的相关性研究
E García,P Darder,J Argüelles et al.
E García et al.
The behavioral aspects of aging in the domestic dog have primarily been investigated through owner-reported scales that measure specific behavioral signs of aging, and laboratory-based memory and cognitive tests. We need to know more about ...
Exploring biomechanical differences between brain-first and body-first Parkinson's disease subtypes using shear wave elastography: a pilot cross-sectional study [0.03%]
采用切变波弹性成像探索帕金森病脑先型和躯干先型的生物力学差异：横断面研究试点项目
Shuangshuang Dong,Bo Shen,Yihong Song et al.
Shuangshuang Dong et al.
Objective: This exploratory study aimed to investigate whether ultrasound shear wave elastography (SWE) could quantify rigidity in Parkinson's disease (PD) and assess potential biomechanical differences between the brain-...
Different structural brain patterns and their association with executive function and general cognitive ability in cognitively normal elderly adults [0.03%]
认知正常老年人不同的脑结构模式及其与执行功能和一般认知能力的关系
Wenjie Pan,Cheng Xu,Cheng Zhu et al.
Wenjie Pan et al.
Objectives: Structural gray matter changes were significantly observed in cognitively normal elderly adults, but the associations between different structural brain patterns, executive function, and general cognitive abil...
Associations between declines in uneven terrain walking speed and visuospatial working memory in older adults [0.03%]
老年人在不平坦地形上行走速度下降与视空间工作记忆之间的关系
Jungyun Hwang,Chang Liu,Steven P Winesett et al.
Jungyun Hwang et al.
Introduction: Mobility and cognitive functions often decline concurrently in older adults, and may be particularly detrimental to walking in complex environments such as uneven terrain. Walking on uneven terrain particula...
The temporal and stimuli-specific effects of LPS and IFNγ on microglial activation [0.03%]
LPS和IFNγ对时间特定性和刺激物特异性的小胶质细胞活化的影响
Christina N Heiss,Andrew S Naylor,Ida Pesämaa et al.
Christina N Heiss et al.
Microglia, the resident immune cells of the central nervous system (CNS), play a pivotal role in health and disease maintaining homeostasis and mediating neuroinflammatory responses. Their activation is a dynamic and context-dependent proce...
Dynamic trends, spatial clustering, and multi-model projections of the global burden of Alzheimer's disease and other dementias: an analysis of GBD 1990-2021 data to 2050 [0.03%]
全球阿尔茨海默病和其他痴呆症疾病负担的动态趋势、空间聚集和多模式预测：对GBD 1990-2021数据至2050年的分析
Fangfang Xiang,Xiaorui Liu,Gang Chen
Fangfang Xiang
Background: Alzheimer's disease and other dementias (ADOD) are a leading causes of disability and mortality among older adults worldwide. While the rising burden is recognized, comprehensive analyses of its dynamic growth...
Correction: Choline alphoscerate: insights between acquired certainties and future perspectives [0.03%]
纠正文章：胆碱阿尔磷酸酯：在获得的确信和未来展望之间的见解
Giovanni Biggio,Claudio Mencacci
Giovanni Biggio
[This corrects the article DOI: 10.3389/fnagi.2025.1613566.]. Keywords: aging; choline alphoscerate; cogniti...
Published Erratum
Frontiers in aging neuroscience. 2026 Jan 29:18:1744201. DOI:10.3389/fnagi.2026.1744201 2026
Spontaneous tauopathy with parkinsonism in an aged cynomolgus macaque [0.03%]
老年食蟹猴自发型tau蛋白病伴帕金森病病理改变
Mirai Takahashi,Daisuke Taniguchi,Manabu Funayama et al.
Mirai Takahashi et al.
Introduction: Aged non-human primates have been reported to develop tau pathology; however, most studies lack evidence of any associated neurological symptoms. To determine whether spontaneous tauopathy in cynomolgus maca...