Pterostilbene restores mitochondrial retrograde signaling to activate protective stress responses in Parkinson's disease [0.03%]
原花青素通过恢复线粒体逆向信号激活保护性应激反应来治疗帕金森病
Fanshuai Zeng,Wei Li,Liyue Yang et al.
Fanshuai Zeng et al.
Parkinson's disease (PD) is the selective demise of dopaminergic neurons in the substantia nigra. Conventional neuroprotective strategies based on exogenous antioxidants have shown minimal clinical efficacy. Emerging evidence suggests that ...
Associations between the red blood cell distribution width and 30-day mortality in critically ill patients with delirium: a retrospective study using the MIMIC-IV database [0.03%]
红细胞分布宽度与重症谵妄患者30天死亡率之间的关联：一项使用MIMIC-IV数据库的回顾性研究
Songmei Ma,Lin Lin,Shuwen Zheng et al.
Songmei Ma et al.
Background: Red blood cell distribution width (RDW) is associated with increased mortality risk in critically ill patients. However, limited data are available on critically ill patients with delirium. ...
Association between motor symptom severity and urinary dysfunction in Parkinson's disease: a retrospective study [0.03%]
帕金森病运动症状严重程度与尿路功能障碍的关系：一项回顾性研究
Jun Seok Lee,Joonsang Yoo,Nak-Hoon Son et al.
Jun Seok Lee et al.
Introduction: Urinary dysfunction is a common non-motor symptom in patients with Parkinson's disease (PD) and is often associated with greater motor disability and reduced quality of life. Despite its clinical relevance, ...
Amyloid pathology modulates the relationship between subsyndromal symptomatic depression and tau accumulation in non-demented older adults [0.03%]
淀粉样蛋白病理性改变调节非痴呆老年人亚综合征症状性抑郁和tau聚集的关系
Jiahe Bai,Xiaonan Wei,Hongchun Wei et al.
Jiahe Bai et al.
Objective: Subsyndromal symptomatic depression (SSD) has been increasingly implicated in the pathophysiological processes of Alzheimer's disease (AD). However, it remains unclear whether SSD and amyloid-β (Aβ) pathology...
Exploring the Mahuang Fuzi Xixin Decoction's mechanism for treating Alzheimer's disease using molecular docking and network pharmacology [0.03%]
基于分子对接和网络药理学的麻黄附子辛夷汤治疗阿尔茨海默病机制探讨
Che Chen,Qianfeng Shao,Sheng Zhou
Che Chen
Objective: Explore the potential mechanism of Mahuang Fuzi Xixin Decoction (MFXD) in the treatment of Alzheimer's disease (AD) using network pharmacology, molecular docking approaches, and test its efficacy by in vitro ex...
Safety and efficacy of extracranial vertebral artery stenting in elderly patients with symptomatic vertebral artery stenosis [0.03%]
老年症状性椎动脉狭窄患者经皮颈段椎动脉支架成形术的疗效分析
Miao Wu,Zhiyong Zhang
Miao Wu
Objectives: Symptomatic stenosis of the extracranial vertebral artery is an important cause of posterior circulation stroke. Endovascular stenting has shown promise for these lesions, but evidence in patients aged ≥ 70 y...
Prognostic value of endothelial activation and stress index in mechanical thrombectomy for patients with acute ischemic stroke [0.03%]
机械取栓治疗急性缺血性卒中的预后价值及内皮激活与应激指数的评估
Xiaohua Zhu,Yunnan Lu,Yaojia Xu et al.
Xiaohua Zhu et al.
Background and purpose: The Endothelial Activation and Stress Index (EASIX) is a marker of endothelial dysfunction. This study aimed to explore the association between the EASIX score and unfavorable outcome in patients w...
Enhanced Parkinson's disease prediction using LDEFS feature selection and Mamdani fuzzy neural network [0.03%]
基于LDEFS特征选择和Mamdani模糊神经网络的帕金森病预测方法研究
M Vijayalakshmi,B Dhiyanesh,D Viji et al.
M Vijayalakshmi et al.
Introduction: Parkinson's Disease (PD) is a progressive neurodegenerative disorder caused by the degeneration of dopaminergic neurons, leading to impairments in speech, motor control, and cognitive functioning. Although r...
The cerebellar-related cognitive function is sensitive to aging: implications for early detection [0.03%]
小脑相关认知功能易受衰老影响：早期检测的意义
Qianying Ma,Min Pu,Meijia Li et al.
Qianying Ma et al.
Background: Accumulating evidence demonstrated that the cerebellum contributes to a wide range of sensorimotor and cognitive functions. However, the relationship between cerebellar function and cognitive abilities in norm...
Character-level linguistic biomarkers for precision assessment of cognitive decline: a symbolic recurrence approach [0.03%]
基于符号复发的痴呆症精确诊断特征研究
Kevin Mekulu,Faisal Aqlan,Hui Yang
Kevin Mekulu
Early-stage Alzheimer's disease (AD) remains difficult to assess using conventional linguistic or cognitive assessments, which often overlook subtle and individualized disruptions in speech. In this work, we propose a novel biomarker discov...