A novel virtual reality-integrated multi-modal intervention for community-dwelling older adults with mild cognitive impairment: protocol for a randomized controlled trial [0.03%]
Yuanbao Sun,Zhuorong Zi,Songli Wang et al.
Yuanbao Sun et al.
Background: Emerging research suggests virtual reality (VR) techniques hold promise for mitigating cognitive decline in patients with mild cognitive impairment (MCI). Furthermore, accumulating evidence indicates that gut ...
Association between perivascular diffusion and white matter microstructural integrity, free water, Aβ burden, and cognition: diffusion tensor vs. kurtosis tensor [0.03%]
Zhiming Zeng,Xin Jia,Shushu Han et al.
Zhiming Zeng et al.
Background: Perivascular diffusion holds great potential for the non-invasive assessment of the glymphatic system (GS). However, Gaussian model-based diffusion tensor imaging analysis along the perivascular space (DTI-ALP...
Deep learning for FDG-PET classification in patients with Alzheimer's disease, dementia with Lewy bodies and their mixed pathology: a solution for diagnostic heterogeneity [0.03%]
Seonggyu Kim,Seun Jeon,Kwonhwi Cho et al.
Seonggyu Kim et al.
Introduction: Mixed pathology of Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) are frequently observed in patients with cognitive impairment, and complicate clinical diagnosis. We aimed to develop a classif...
Telomere dysfunction is associated with exacerbated intermittent hypoxia-induced cognitive deficits and nerve damage [0.03%]
Ying Guo,Yuyang Miao,Jin Tan et al.
Ying Guo et al.
Cognitive impairment associated with obstructive sleep apnea (OSA) is more prevalent and severe in the elderly, possibly due to age-related increases in neuronal susceptibility to intermittent hypoxia (IH). As telomere dysfunction is a key ...
Michał Adamski,Miroslaw Latka,Anna Latka et al.
Michał Adamski et al.
Introduction: In the classic Rod-and-Frame Test (RFT), participants align a pivoted rod with the vertical while viewing a tilted, coaxially mounted frame. In doing so, they can use the edge of the frame or its imaginary d...
A Rizzato,M Bozzato,A Paoli et al.
A Rizzato et al.
Background: Age-related changes in the neuromuscular and sensory systems compromise the control of balance and stability. Static balance assessments may overlook deficits that appear when coping with unexpected perturbati...
Emerging pathological mechanisms of Alzheimer's disease pathogenesis: from neuroimmune interactions to intercellular communication [0.03%]
Rutong Wang,Yingqi Feng,Ziyu Zhou et al.
Rutong Wang et al.
Alzheimer's disease (AD) research has transcended the traditional paradigm centered on amyloid-beta (Aβ) shifting toward a neuroimmune network perspective. This article systematically elucidates the evolving mechanisms underlying disease p...
Diet, gut microbiome, and cognition in neurodegeneration: a review and methodological framework [0.03%]
Jacob Raber,Thomas J Sharpton
Jacob Raber
The gut microbiome influences brain function through the gut-brain axis via synthesis of neurotransmitters, production of metabolites affecting epithelial barrier integrity and immune modulation and signaling through the vagus nerve. In hum...
TAS2R38 taster variants-linked MGAM expression in Alzheimer's disease: a novel target for precision drug repurposing [0.03%]
Claire W Su,Kewei Chen,Teresa Wu et al.
Claire W Su et al.
Introduction: TAS2R38 is a taste receptor gene located on human chromosome 7 that influences sensitivity to bitter tastes and has been implicated in innate immunity, glucose level, and human longevity. However, its potent...
Exploring the neuroprotective mechanism of Tongqiao Huashuan granules in vascular dementia based on PLCγ1/IP3R signaling pathway [0.03%]
Xianhui Huang,Jiajia Liu,Yanna Ren et al.
Xianhui Huang et al.
Introduction: Vascular dementia (VaD) is closely associated with oxidative stress and intracellular calcium overload. PLCγ1, IP3R, CAMKKII, and CaM proteins play important roles in mediating intracellular calcium overloa...