The role of NLRP3 inflammasome in age-related macular degeneration: mechanisms and therapeutic prospects [0.03%]
NLRP3炎性小体在年龄相关性黄斑变性中的作用：机制和治疗前景
Meijiao Zhu,Weihong Yu
Meijiao Zhu
Age-related macular degeneration (AMD) is a fundus oculi disease that progressively impairs the central vision of patients. To date, its pathogenesis has not been fully elucidated, and therapeutic options for dry AMD remain limited. Recentl...
Blood transcriptomic signatures link β-amyloid deposition to molecular pathways across SCD, MCI, and dementia [0.03%]
血液转录组特征揭示了β淀粉样蛋白沉积在轻度认知障碍和痴呆中的分子途径变化
Yijia Lin,Lizhen Cheng,Zhen Zhang et al.
Yijia Lin et al.
Introduction: Brain β-amyloid (Aβ) accumulation is a hallmark of Alzheimer's disease, but noninvasive detection remains challenging. Blood transcriptomics may provide accessible biomarkers associated with Aβ pathology....
Plaque-associated microglial polarization in visual brain regions of the 5xFAD mouse model [0.03%]
5xFAD小鼠模型视觉脑区斑块相关的小胶质细胞极化现象
Shaylah McCool,Arnav Jain,Jennie C Smith et al.
Shaylah McCool et al.
Introduction: Alzheimer's disease (AD), a neurodegenerative disorder associated with amyloid beta (Aβ) plaque deposition, leads to cognitive decline in affected individuals. Vision changes are among the reported symptoms...
Which exercise intervention is most promising for Parkinson's balance? A network meta-analysis [0.03%]
哪种锻炼干预措施最有助于帕金森病患者的平衡？网络-meta-分析
Ying Li,Meiling Zhao,Zhaojun Luo et al.
Ying Li et al.
Objective: Parkinson's disease (PD) is a chronic, progressive, and disabling neurodegenerative disorder. While bradykinesia, resting tremor, and rigidity are the cardinal motor symptoms, balance impairments and postural i...
Haibo Ning,Lei Chen,Min Wang et al.
Haibo Ning et al.
Objective: The purpose of this study is to ascertain the incidence of fatigue and to determine the cross-sectional associate and related variables of fatigue in patients with Parkinson's disease (PD). ...
Methodological innovations in studying marginalized populations in research on neurodegeneration and ageing [0.03%]
神经退行性和衰老研究中边缘化人群的研究方法创新
Anja K Leist,Eva Teyssier,Jure Mur
Anja K Leist
Underrepresented populations, often characterized by minority ethnicity, sex/gender or low socioeconomic status, have a higher risk burden and more adverse lifetime experiences of conditions negatively impacting cognitive health than better...
Heterogeneous cognitive and neuroimaging profiles in older adults with type 2 diabetes: the modifying effect of coronary artery disease [0.03%]
冠心病对2型糖尿病老年人认知障碍和脑影像异质性影响的介导作用研究
Qingjuan Ren,Lei Zhi,Hongfang Liu
Qingjuan Ren
Background: Cognitive impairment in older adults with type 2 diabetes mellitus (T2DM) is increasingly recognized, and coronary artery disease (CAD) is also linked to cognitive decline. However, their combined impact remai...
Dual decline in gait and cognition as a high-risk clinical phenotype: differential associations with cerebral amyloid- β deposition and the apolipoprotein E ε4 allele and implications for integrated assessment [0.03%]
步态和认知双重减退的高危临床表型及其与脑淀粉样病变和APOEε4等位基因的相关性及对综合评估的意义
Chenxi Ren,Jiehua Zhu,Lin Huang et al.
Chenxi Ren et al.
Background: Gait slowing and cognitive impairment often coexist in older adults, yet their relationship with core Alzheimer's disease (AD) biomarkers remains incompletely understood. ...
Clinical heterogeneity of Pisa syndrome across Lewy body disorders: a multicenter comparison of Parkinson's disease and dementia with Lewy bodies [0.03%]
临床帕金森症候群在路易体障碍中的异质性：帕金森病与路易体痴呆的多中心对比研究
Zhou Su,Mengran Liu,Jun Kuai et al.
Zhou Su et al.
Background: Pisa syndrome (PS) is well recognized in Parkinson's disease (PD) but has been less studied in dementia with Lewy bodies (DLB), and direct comparisons are scarce. The aim of this study is to compare the clinic...
Pre-plaque glutamatergic hyperexcitability, mitochondrial dysfunction, and dendritic remodeling in the hippocampus of one-month-old 5xFAD mice [0.03%]
五倍突变FAD小鼠海马区淀粉样蛋白斑产生前的谷氨酸能神经元过度兴奋、线粒体功能障碍和树突重塑现象研究
Amanda R Kelley,Emily Sackinger,Mathew Frischman et al.
Amanda R Kelley et al.
Alzheimer's disease (AD) is characterized by progressive cognitive decline and stereotyped neuropathology, yet the earliest cellular events that precede overt plaque burden and measurable behavioral impairment remain incompletely defined. H...