Pharmacologically increasing O-GlcNAcylation increases complexity of astrocytes in the dentate gyrus of TgF344-AD rats [0.03%]
通过药理学方法提高O-GlcNAc酰化可增加TgF344-AD大鼠海马齿状回星形胶质细胞的复杂度
Melissa L Garcia,Adam R Denton,Nateka L Jackson et al.
Melissa L Garcia et al.
Background: Alzheimer's disease (AD) pathology begins two or three decades prior to the onset of cognitive symptoms and is characterized by amyloid-β (Aβ) and hyperphosphorylated tau (pTau) accumulation, reactive glial ...
A lightweight cerebrospinal fluid biomarker-based model for first-diagnosis prediction of Parkinson's disease: model development, external validation, and local deployment [0.03%]
基于轻量级脑脊液生物标志物的帕金森病初次诊断预测模型：模型开发、外部验证和本地部署
Xinchao Hu,Yu Liu,Yuan Cao et al.
Xinchao Hu et al.
Background: Despite substantial progress in biomarker research, Parkinson's disease (PD) still lacks widely validated, easily deployable diagnostic tests for reliable early-stage detection, particularly in resource-limite...
Hippocampal T1WI radiomics- and clinical feature-based models for predicting early mild cognitive impairment in secondary hydrocephalus [0.03%]
基于影像组学和临床特征的正常压力脑积水早期轻度认知障碍预测模型研究
Xiaofeng Wang,Ziao Xu,Bohang Liu et al.
Xiaofeng Wang et al.
Introduction: Mild cognitive impairment (MCI) represents the initial stage of dementia, and early diagnosis is crucial in clinical practice. This study aimed to investigate the predictive performance of three models based...
Transcranial stimulation combined with four rehabilitation therapies for gait and motor function in Parkinson's disease: a network meta-analysis of 23 RCTs [0.03%]
经颅刺激联合四种康复疗法对帕金森病步态和运动功能的疗效：23项随机对照试验的网络meta分析
Dongyue Li,Xinyu Lin,Haojie Li et al.
Dongyue Li et al.
Introduction: Parkinson's disease (PD) has become the fastest-growing neurological disease worldwide. This network meta-analysis evaluated the efficacy of transcranial stimulation combined with four rehabilitation approac...
Dexmedetomidine ameliorates cognitive and affective deficits by modulating neuroinflammation and neurogenesis in an Alzheimer's disease mouse model [0.03%]
右美托咪啶通过调节小鼠阿尔茨海默病模型中的神经炎症和神经发生来改善认知和情感缺陷
Mai Li,Chanyuan An,Xin Wang et al.
Mai Li et al.
Alzheimer's disease (AD) involves progressive cognitive decline and neuropsychiatric symptoms that are strongly linked to neuroinflammation and aberrant hippocampal neurogenesis. We examined whether dexmedetomidine (Dex), a clinically used ...
The efficacy versus evidence quality of multicompomnent exercise for cognitive health in older adults: an umbrella review [0.03%]
多成分运动改善老年人认知健康的疗效和证据质量：伞式评审
Weibao Liang,Chuannan Liu,Xujie Yan et al.
Weibao Liang et al.
Introduction: Multicomponent exercise (MCE) is a promising strategy for enhancing cognitive function in older adults. This umbrella review aimed to synthesize and critically appraise the evidence from systematic reviews a...
HALP, PIV, and SII as novel composite inflammatory indices for early detection and severity assessment of Alzheimer's disease [0.03%]
新型炎症复合指标HALP、PIV和SII在阿尔茨海默病早期检测及严重程度评估中的作用研究
Chao Huang,Chenxi Lu,Shuai Liu et al.
Chao Huang et al.
Objective: This study aimed to evaluate the diagnostic and prognostic value of the Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) Score, the Pan-Immune-Inflammation Value (PIV), and the Systemic-Immune-Inflammation ...
Parkinson's disease physiopathology-beyond the α-synuclein aggregation: a narrative review [0.03%]
帕金森病生理病理学-超越α-突触核蛋白聚集：综述性文章
Victor Fellipe Bispo Macedo,Vanessa Karine Bispo Macedo,Jorge Artur Peçanha de Miranda Coelho et al.
Victor Fellipe Bispo Macedo et al.
Background: Parkinson's disease (PD) is traditionally defined by dopaminergic degeneration and α-synuclein aggregation. However, mounting evidence supports a multifactorial and systemic pathophysiology that extends beyon...
Machine learning methods for the detection and prediction of cognitive impairment in Parkinson's disease: a systematic review and meta-analysis [0.03%]
帕金森病认知障碍检测和预测的机器学习方法系统评价及荟萃分析
Hong Jiang,Xinling Yang,Wenxing Wang et al.
Hong Jiang et al.
Background: Cognitive impairment in Parkinson's disease (PD-CI) is a prevalent non-motor symptom, significantly diminishing quality of life and imposing a substantial family burden. Effective predictive tools are currentl...
Challenges in neuropsychological improvement after shunt surgery for idiopathic normal pressure hydrocephalus [0.03%]
正常压力性脑积水术后神经心理改善的挑战性研究
Ondřej Rýdlo,Adéla Bubeníková,Petr Skalický et al.
Ondřej Rýdlo et al.
Objectives: To evaluate cognitive and mood changes 3 months after shunting for idiopathic normal-pressure hydrocephalus (iNPH), and compare postoperative outcomes with matched healthy controls across cognitive domains. ...