Molecular pathways in vascular cognitive impairment and dementia: focus on synaptic plasticity and epigenetic modifications [0.03%]
血管性认知障碍和痴呆的分子途径：突触可塑性和表观遗传修饰:focus
Chuanqiang Liu,Fuyue Li,Luyao Qiao et al.
Chuanqiang Liu et al.
Background: Vascular cognitive impairment (VCI) is a group of cognitive disorders caused by cerebrovascular disease and is the second leading cause of dementia. VCI prevalence has significantly increased over the past dec...
Oxytocin reduces anger bias, harm-intention recognition, and self-focus in behavioral variant frontotemporal dementia: a randomized double-blind placebo-controlled crossover trial [0.03%]
催产素减少行为变异性额颞叶痴呆患者的愤怒偏向、伤害意图识别及自我关注：随机双盲安慰剂对照交叉试验
Valentina Colonnello,Sabina Capellari,Maria Guarino et al.
Valentina Colonnello et al.
Objective: To explore the effects of oxytocin administration on social cognition and social engagement in patients with behavioral variant frontotemporal dementia. ...
Identification of CTHRC1 as a novel candidate for neurodevelopmental disorders [0.03%]
CTHRC1被鉴定为神经发育障碍的新候选基因
Jie Xu,Yuan He,Zhao Li et al.
Jie Xu et al.
Background: Cognitive dysfunction affects over 50 million individuals worldwide, with Alzheimer's disease (AD) representing two-thirds of cases. We identified CTHRC1 (Collagen Triple Helix Repeat Containing 1) as a novel ...
Multimodal imaging and machine learning for diagnosis of Parkinson's disease with cognitive impairment: ASL and QSM as potential biomarkers [0.03%]
多模态影像和机器学习在帕金森病伴认知障碍诊断中的应用及ASL和QSM的生物标志物价值研究
Weimin Qi,Jiang Cheng,Xiuping Zhan et al.
Weimin Qi et al.
Objectives: This study aimed to investigate differences in brain imaging characteristics among patients with Parkinson's disease with cognitive impairment (PDCI), Parkinson's disease without cognitive impairment (PDNCI), and healthy control...
Analysis of cognitive function trajectories and influencing factors in elderly patients with ischemic stroke: a prospective longitudinal study [0.03%]
缺血性卒中老年人认知功能转归及影响因素纵向研究分析
Xinhao Chen,Chengxia Wei,Danli Zhao et al.
Xinhao Chen et al.
Background and purpose: Accurately defining cognitive function trajectories in elderly ischemic stroke patients is crucial for identifying high-risk groups for cognitive decline, enabling timely personalized interventions...
Older adult solitary drinking: associations with subjective and objective cognitive functioning [0.03%]
独居老年人饮酒与主观认知功能和客观认知功能的关系
Carillon J Skrzynski,Angela D Bryan
Carillon J Skrzynski
Background: Solitary drinking is a pattern of hazardous alcohol consumption that is problematic at any age but is more prevalent in older adults, yet most research focuses on younger samples. Research on solitary drinking...
Intrinsic mechanical vibrations as a missing dimension in amyloid- β clearance: a mechanochemical hypothesis for Alzheimer's disease [0.03%]
淀粉样蛋白-β清除中内在机械振动这一缺失维度：阿尔茨海默病的机械化学假说
Xiaochen Lai
Xiaochen Lai
Alzheimer's disease is widely viewed as a disorder of disturbed amyloid-β (Aβ) homeostasis, yet it remains unclear why Aβ shifts from routine turnover to progressive retention and plaque growth in mid-life. This article advances a mechan...
Intestinal barrier compromise, viral persistence, and immune dysregulation converge on neurological sequelae in Long COVID [0.03%]
肠道屏障功能障碍、病毒持续存在和免疫失调在长新冠的神经后遗症中汇聚
Laurence Leclerc,Johanne Poudrier,Christopher Power et al.
Laurence Leclerc et al.
Long COVID (LC) is a multisystem, post-infectious conditions diagnosed ≥3 months after acute SARS-CoV-2 infection and marked by relapsing, persistent, or progressive symptoms, especially fatigue, post-exertional symptom exacerbation and ne...
Human cytomegalovirus infection and cognitive decline: insights from population and experimental studies [0.03%]
人巨细胞病毒感染与认知能力下降：来自人群和实验研究的见解
Koon Chu Yaiw,Isidre A Ferrer,Cecilia Söderberg-Nauclér et al.
Koon Chu Yaiw et al.
Human cytomegalovirus (HCMV), a ubiquitous DNA betaherpesvirus, is capable of persistent infection and immunomodulation, particularly in immunocompromised and elderly hosts. Emerging evidence links HCMV to neurodegenerative diseases through...
White matter hyperintensities and late-life cognition: an analysis of moderation effects of mild behavioral impairment [0.03%]
轻度行为异常对白质高信号与晚年认知关系的调节作用分析
Jiayu Duan,Ningqun Wang,Shixin Li et al.
Jiayu Duan et al.
Background: Mild behavioral impairment (MBI) is recognized as a potential early marker for dementia and may be indicative of the increased risk in the predementia stage. This study investigated whether MBI could moderate ...