Quantity and quality of care and staff knowledge regarding people with Parkinson's disease in long-term nursing care: "real-life" results from the German Care4PD study [0.03%]
德国Care4PD研究中的帕金森病长期护理情况：护理质量和数量及工作人员知识水平的“现实结果”
Odette Fründt,Verena Caroline Lamb,Anne-Marie Hanff et al.
Odette Fründt et al.
Introduction: Approximately 20% of people with Parkinson's disease (PwP) in Germany need professional long-term care (LTC). Previous data have indicated a rather poor LTC situation and the need for more profound analyses....
Altered resting-state functional connectivity of raphe nucleus is associated with tremor in Parkinson's disease [0.03%]
帕金森病静息态下黑质网状核功能连接改变与震颤相关性研究
Qianyi Zheng,Dongling Zhang,Junyan Sun et al.
Qianyi Zheng et al.
Introduction: Tremor is a prevalent and disabling motor symptom in Parkinson's disease (PD). The role of the serotonergic system in Parkinsonian tremor remains unclear. We aimed to investigate whether functional connectiv...
Integrated bioinformatics analysis reveals Netrin-1 as a key molecular link between Parkinson's disease and heart failure [0.03%]
整合生物信息学分析揭示Netrin-1是帕金森病和心力衰竭的关键分子联系
Zhen Ni,Gaoge Wang,Yingyan Li et al.
Zhen Ni et al.
Background: Parkinson's disease (PD) patients face a higher risk of developing heart failure (HF). The objective of the study was to investigate the hub genes and potential mechanisms linking Parkinson's disease (PD) to h...
Treadmill exercise alleviates Alzheimer's disease pathologies in APP/PS1 mice through modulation of microglial glucose metabolic reprogramming [0.03%]
跑步机运动通过调节小胶质细胞糖代谢重编程缓解APP / PS1小鼠的阿尔茨海默病病理变化
Fei Liang,Feng Sun,Cuijun Guo et al.
Fei Liang et al.
Objective: Our preliminary studies have demonstrated that exercise counteracts Alzheimer's disease (AD) by mitigating microglia-mediated neuroinflammation and enhancing microglial Aβ clearance. However, the underlying me...
Body composition and cognitive function in Chinese rural adults: an exploratory factor analysis and network analysis [0.03%]
中国农村成人身体组成与认知功能的探索性因子分析及网络分析
Lei Wang,Hongjuan Liu,Xianfeng Meng et al.
Lei Wang et al.
Background: Growing evidence suggests that body composition has a significant influence on cognitive function. However, their relationship remains controversial. This study investigated the association between body compos...
Boyan Wang,Di Ma,Na Li et al.
Boyan Wang et al.
Background: Parkinson's disease (PD) is a multisystem neurodegenerative disorder characterized by the aggregation of α-synuclein (α-syn) in dopaminergic neurons of the substantia nigra. The pathogenesis of PD remains in...
Qi-Fu-Yin ameliorates physiological frailty in male 5xFAD mice through remodeling the gut microbiota and modulating the cerebral cortex metabolism [0.03%]
祛馥音通过重塑肠道菌群和调节脑皮层代谢改善5xFAD雄鼠生理脆弱性
Yitong Xiao,He Li,Xinyuan Han et al.
Yitong Xiao et al.
Introduction: Alzheimer's disease (AD) is a neurodegenerative disease that can only be managed rather than cured, bringing a substantial burden to society. Frailty and cognition are intertwined in a cycle of decline, affe...
Pharmacologically increasing O-GlcNAcylation increases complexity of astrocytes in the dentate gyrus of TgF344-AD rats [0.03%]
通过药理学方法提高O-GlcNAc酰化可增加TgF344-AD大鼠海马齿状回星形胶质细胞的复杂度
Melissa L Garcia,Adam R Denton,Nateka L Jackson et al.
Melissa L Garcia et al.
Background: Alzheimer's disease (AD) pathology begins two or three decades prior to the onset of cognitive symptoms and is characterized by amyloid-β (Aβ) and hyperphosphorylated tau (pTau) accumulation, reactive glial ...
A lightweight cerebrospinal fluid biomarker-based model for first-diagnosis prediction of Parkinson's disease: model development, external validation, and local deployment [0.03%]
基于轻量级脑脊液生物标志物的帕金森病初次诊断预测模型：模型开发、外部验证和本地部署
Xinchao Hu,Yu Liu,Yuan Cao et al.
Xinchao Hu et al.
Background: Despite substantial progress in biomarker research, Parkinson's disease (PD) still lacks widely validated, easily deployable diagnostic tests for reliable early-stage detection, particularly in resource-limite...
Hippocampal T1WI radiomics- and clinical feature-based models for predicting early mild cognitive impairment in secondary hydrocephalus [0.03%]
基于影像组学和临床特征的正常压力脑积水早期轻度认知障碍预测模型研究
Xiaofeng Wang,Ziao Xu,Bohang Liu et al.
Xiaofeng Wang et al.
Introduction: Mild cognitive impairment (MCI) represents the initial stage of dementia, and early diagnosis is crucial in clinical practice. This study aimed to investigate the predictive performance of three models based...