An integrated CSF-serum biomarker model for predicting clinical progression in Alzheimer's disease [0.03%]
整合脑脊液-血浆生物标志物模型预测阿尔茨海默病的临床进展
Xichun Wang,Ye Tang,Qiwen Zhang et al.
Xichun Wang et al.
Background: The early and accurate identification of Alzheimer's disease (AD) remains a significant clinical challenge. Integrating novel peripheral blood-based biomarkers with established cerebrospinal fluid (CSF) measur...
Dual roles of lactate and lactylation modification in the nervous system: neuroprotection and neuroinjury [0.03%]
乳酸和乳酸化修饰在神经系统中的双重作用：神经保护与神经损伤
TianLu Ran,YunLong Shen,DeJian Peng et al.
TianLu Ran et al.
Lactate is the terminal product of anaerobic oxidation within the glucose metabolism pathway. Traditionally, lactate has been regarded as a metabolically insignificant byproduct derived from incomplete oxidation. However, recent evidence su...
Leveraging object detection for early diagnosis of neurodegenerative diseases through radiomic analysis [0.03%]
基于影像组学分析的物体检测在神经退行性疾病早期诊断中的应用
Wenhong Zhi,Zhiguang Liu,Linjian Huang et al.
Wenhong Zhi et al.
Introduction: Early diagnosis of neurodegenerative diseases remains a formidable challenge in modern neuroimaging, due to subtle and heterogeneous brain deterioration patterns in early disease stages. Integrating artifici...
Gamma-aminobutyric acid associated research in Parkinson's disease: an exploratory trends analysis [0.03%]
帕金森病相关γ-氨基丁酸研究趋势分析：基于文献的探索性研究
Sheng-Qiang Zhou,Fang Liu,Yan-Jun Chen et al.
Sheng-Qiang Zhou et al.
Background: Parkinson's disease (PD) is a neurodegenerative disease characterized by the progressive loss of dopaminergic neurons. Gamma-aminobutyric acid (GABA), as a key inhibitory neurotransmitter, participates in phys...
Advances in the multifunctional roles of CX3CL1 in the central nervous system [0.03%]
趋化因子CX3CL1在中枢神经系统多功能作用的进展
Yuhui Chen,Junli Liu,Sen Zhang et al.
Yuhui Chen et al.
C-X3-C motif chemokine ligand 1 (CX3CL1), a structurally unique chemokine in the central nervous system (CNS), shapes physiological and pathological processes via specific binding to its receptor, C-X3-C motif chemokine receptor 1 (CX3CR1)....
Effects of different types of deep brain stimulation on gait disorders in patients with Parkinson's disease: a network meta-analysis of randomized controlled trials [0.03%]
不同类型的脑深部刺激对帕金森病步态障碍影响的网状meta分析：随机对照试验研究
Yunpeng Guo,Zhanyi Zhang,Yixian Hou
Yunpeng Guo
Objective: To systematically compare and rank the relative efficacy of different types of deep brain stimulation (DBS) for gait disorders in patients with Parkinson's disease (PD), with particular emphasis on three outcom...
18F-FDG PET/MR reveals specific brain metabolic features in Parkinson's disease with frailty [0.03%]
18F-FDG PET/MR揭示帕金森病伴衰弱的特定脑代谢特征
Guoyang Li,Wenli Zhang,Fengju Mao et al.
Guoyang Li et al.
Background: Frailty is significantly more prevalent in individuals with Parkinson's disease (PD) than in general population, yet the underlying neuropathophysiological mechanisms remain poorly understood. This study aimed...
The effects of video games on cognitive function in older adults with mild cognitive impairment: a meta-analysis [0.03%]
老年人轻度认知障碍视频游戏认知功能元分析研究
Bo Liu,Xiaomei Li,Hejia Cai
Bo Liu
Objective: This study aimed to evaluate the efficacy of video-game-based interventions in enhancing global cognitive function and executive functioning among individuals with mild cognitive impairment (MCI). ...
Editorial: Preserving emotional health in aging: unraveling the neural mechanisms and implications for neurodegenerative diseases [0.03%]
述评：解析情感健康的神经机制及其在神经退行性疾病中的意义
Quelen Iane Garlet,Daniel Felsky,Kiyotaka Nemoto
Quelen Iane Garlet
Impact of obstructive sleep apnea on gut microbiome of patients with symptomatic intracranial atherosclerotic stenosis [0.03%]
阻塞性睡眠呼吸暂停对有症状颅内动脉粥样硬化性狭窄患者肠道微生态的影响
Shuoxi Liao,Hui Yang,Li Song et al.
Shuoxi Liao et al.
Introduction: Obstructive sleep apnea syndrome (OSAS) is positively associated with increased risks of ischemic stroke. Patients with stroke exhibit remarkable gut microbiota dysbiosis. However, the impact of OSAS on gut ...