Mechanistic insights into the anti-neuroinflammatory effects of cassia obtusifolia in Parkinson's disease: a network pharmacology-based study [0.03%]
基于网络药理学的番泻叶抗神经炎症效应治疗帕金森病的作用机制研究
Xinfu Lian,Yongjun Bai,Rong Xie et al.
Xinfu Lian et al.
Background: Parkinson's disease (PD) is a chronic neurodegenerative disorder that is closely associated with neuroinflammation, yet effective anti-inflammatory therapies remain limited. This study aimed to elucidate the p...
LRP1 at the crossroads of Aβ clearance and therapeutic targeting in Alzheimer's disease [0.03%]
LRP1在阿尔茨海默病中的Aβ清除和治疗靶点的交汇点
Yuepeng Deng,Haolin Yin,Zihao Lu et al.
Yuepeng Deng et al.
Alzheimer's disease (AD), characterized by progressive cognitive decline, memory impairment and behavioral disturbances, is the most common form of dementia, and no disease-modifying treatments are available to halt or slow its progression....
Altered brain network dynamics and functional connectivity in subjective cognitive decline: an edge-centric network study [0.03%]
主观认知下降患者的脑网络动态和功能连接改变：基于边的网络研究
Xiaofan Wei,Baiwan Zhou,Juanling Li et al.
Xiaofan Wei et al.
Purpose: To explore neurodynamic bases underlying subjective cognitive decline (SCD) based on edge-centric functional network. Methods: ...
The alterations in brain network functional gradients and dynamic functional connectivity in Alzheimer's disease: a resting-state fMRI study [0.03%]
阿尔茨海默病中脑网络功能梯度和动态功能连接的改变：一项静息态fMRI研究
Benqin Liu,Chunbing Chen,Pan Cai et al.
Benqin Liu et al.
Background and purpose: Alzheimer's disease (AD), the most common form of dementia worldwide, is characterized by progressive cognitive decline. Extensive evidence from dynamic functional connectivity (dFC) studies has de...
Follicle-stimulating hormone linked to cognitive decline and amyloid burden in postmenopausal women [0.03%]
促卵泡激素与绝经后妇女的认知衰退和淀粉样蛋白负担有关
Sheng-Min Wang,Chaiho Jeong,Yoo Hyun Um et al.
Sheng-Min Wang et al.
Introduction: Women have a higher risk of developing Alzheimer's disease (AD) than men, with hormonal changes during menopause being a potential factor. However, the exact relationship between these hormonal changes, cogn...
AI agents in Alzheimer's disease management: challenges and future directions [0.03%]
人工智能在阿尔茨海默病管理中的挑战及未来方向
Gerasimos Grammenos,Aristidis G Vrahatis,Konstantinos Lazaros et al.
Gerasimos Grammenos et al.
Neurodegenerative diseases such as Alzheimer's and Parkinson's disease pose a major global healthcare challenge, with cases projected to rise sharply as populations age and effective treatments remain limited. AI has shown promise in suppor...
Functional data analysis of heart rate variability from continuous ECG monitoring in older adults with and without mild cognitive impairment [0.03%]
功能数据分析连续心电图监测老年人心率变异性（有和无轻度认知障碍）
Jiyue Qin,Carol A Derby,Grace Liu et al.
Jiyue Qin et al.
Background: Reduced heart rate variability (HRV) has been associated with cognitive decline in older adults. However, prior research relied on brief in-clinic electrocardiography (ECG) recordings to measure HRV. Using 7-d...
Factors associated with sleep disorders in elderly patients with Parkinson's disease and cognitive impairment and the nomogram model development [0.03%]
帕金森病伴认知障碍老年人睡眠障碍的影响因素及预测模型研究
Yimei Zhang,Liyan Sun,Haitao Chi
Yimei Zhang
Background: Sleep disorders are a common complication in elderly patients with Parkinson's disease and cognitive impairment. This retrospective cohort study investigates the factors associated with sleep disorders in elde...
Machine learning models for the prediction of levodopa response to tremor in Parkinson's disease [0.03%]
帕金森病左旋多巴治疗患者震颤反应的机器学习模型预测能力研究
Fangfei Li,Shinuan Lin,Rui Yan et al.
Fangfei Li et al.
Objectives: To develop and validate machine learning models to predict levodopa responsiveness of tremor in Parkinson's disease (PD) patients. Methods: ...
Depressive symptoms mediate the relationship between cognitive reserve and cognitive performance in middle-aged and older Chinese adults: evidence from population-based and clinical PET cohorts including cognitively normal and cognitively impaired participants [0.03%]
认知储备与中老年人认知表现的关系受抑郁症状的介导：来自大规模人群和临床PET队列（包含正常和受损认知参与者）的证据
Yucheng Gu,Xiaoyuan Li,Nihong Chen et al.
Yucheng Gu et al.
Background: Cognitive reserve (CR) may protect cognitive performance under pathology. Depressive symptoms are common in mid and late life and are linked to poorer cognition. This study investigated whether depressive symp...