Killer or helper? The mechanism underlying the role of adenylate activated kinase in sound conditioning [0.03%]
杀手还是帮手？腺苷酸活化蛋白激酶在噪声作用下的机制研究
Rui Zhao,Changhong Ma,Minjun Wang et al.
Rui Zhao et al.
Objective: To investigate whether sound conditioning influences auditory system protection by activating adenylate activated kinase (AMPK), and if such adaption protects ribbon synapses from high-intensity noise exposure....
The plasticity of cardiac sympathetic nerves and its clinical implication in cardiovascular disease [0.03%]
心脏交感神经的可塑性及其在心血管疾病中的临床意义
Hideaki Kanazawa,Keiichi Fukuda
Hideaki Kanazawa
The heart is electrically and mechanically controlled by the autonomic nervous system, which consists of both the sympathetic and parasympathetic systems. It has been considered that the sympathetic and parasympathetic nerves regulate the c...
Editorial: Quantifying and controlling the nano-architecture of neuronal synapses [0.03%]
编者按：量化和控制神经突触的纳米结构
Xiaobing Chen,Thomas Kuner,Thomas A Blanpied
Xiaobing Chen
Vagally-mediated heart block after myocardial infarction associated with plasticity of epicardial neurons controlling the atrioventricular node [0.03%]
心梗后迷走神经介导的心房-结传导阻滞与支配房室结的冠状外神经可塑性相关
John D Tompkins,Una Buckley,Siamak Salavatian et al.
John D Tompkins et al.
Imbalances in the opposing actions of sympathetic and parasympathetic nerves controlling the heart enhance risk for arrhythmia and sudden cardiac death after myocardial infarction (MI). Plasticity in peripheral neuron function may underlie ...
Synaptic determinants of cholinergic interneurons hyperactivity during parkinsonism [0.03%]
帕金森病时胆碱能中间神经元活性高的突触决定因素
Montserrat Padilla-Orozco,Mariana Duhne,Alejandra Fuentes-Serrano et al.
Montserrat Padilla-Orozco et al.
Parkinson's disease is a neurodegenerative ailment generated by the loss of dopamine in the basal ganglia, mainly in the striatum. The disease courses with increased striatal levels of acetylcholine, disrupting the balance among these modul...
Targeting prefrontal cortex GABAergic microcircuits for the treatment of alcohol use disorder [0.03%]
靶向额皮质GABA能微环路治疗酒精使用障碍
Kenneth N Fish,Max E Joffe
Kenneth N Fish
Developing novel treatments for alcohol use disorders (AUDs) is of paramount importance for improving patient outcomes and alleviating the suffering related to the disease. A better understanding of the molecular and neurocircuit mechanisms...
Olivia M S Gold,Emma N Bardsley,Anna P Ponnampalam et al.
Olivia M S Gold et al.
The carotid body is the primary peripheral chemoreceptor in the body, and critical for respiration and cardiovascular adjustments during hypoxia. Yet considerable evidence now implicates the carotid body as a multimodal sensor, mediating th...
Synaptic spinules are reliable indicators of excitatory presynaptic bouton size and strength and are ubiquitous components of excitatory synapses in CA1 hippocampus [0.03%]
突触棘是CA1海马区兴奋性突触的普遍组成成分，可作为兴奋性突触小节大小和强度的可靠指标
Ashley Gore,Amaliya Yurina,Anastasia Yukevich-Mussomeli et al.
Ashley Gore et al.
Synaptic spinules are thin, finger-like projections from one neuron that become embedded within the presynaptic or postsynaptic compartments of another neuron. While spinules are conserved features of synapses across the animal kingdom, the...
Assessment of cardiac function in rat endovascular perforation model of subarachnoid hemorrhage; A model of subarachnoid hemorrhage-induced cardiac dysfunction [0.03%]
兔亚急性股动脉狭窄模型的构建及血管内皮功能检测实验研究
Masahito Munakata,Hideaki Kanazawa,Kensuke Kimura et al.
Masahito Munakata et al.
Although the association between cardiac dysfunction and subarachnoid hemorrhage (SAH) has been recognized, its precise underlying mechanism remains unknown. Furthermore, no suitable animal models are available to study this association. He...
Differential modulation of collybistin conformational dynamics by the closely related GTPases Cdc42 and TC10 [0.03%]
Cdc42和TC10密切相关的GTP酶通过不同的方式调节collybistin的构象动力学
Nasir Imam,Susobhan Choudhury,Katrin G Heinze et al.
Nasir Imam et al.
Interneuronal synaptic transmission relies on the proper spatial organization of presynaptic neurotransmitter release and its reception on the postsynaptic side by cognate neurotransmitter receptors. Neurotransmitter receptors are incorpora...