GABAB receptors negatively modulate excitatory plasticity at the mossy fiber synapse onto parvalbumin-expressing basket and axo-axonic cells in the dentate gyrus [0.03%]
GABAＢ受体通过调节内侧齿状回胆碱能 mossy fiber-granule cell环路的长时程增强来抑制颗粒细胞兴奋性
Rita M Loureiro,Sam A Booker,Akos Kulik et al.
Rita M Loureiro et al.
Introduction: GABAB receptors (GABABRs) are important modulators of neuronal excitability, synaptic transmission and plasticity in principal cells (PCs). While at the cellular level they can inhibit synaptic transmission ...
Opposite serotonergic modulation of sharp waves in the dorsal and ventral hippocampus [0.03%]
海马背腹侧区锐波的相反的血清素调制作用
Charalampos L Kandilakis,Costas Papatheodoropoulos
Charalampos L Kandilakis
Serotonin plays a crucial role in regulating hippocampal network dynamics, however, its effects on sharp wave-ripples (SPWs), a pattern fundamental for memory consolidation and emotional processing, remain incompletely understood, particula...
Is it possible to prevent excessive synaptic pruning in schizophrenia? Possibilities and limitations [0.03%]
预防精神分裂症中过度的突触修剪是可能的吗？可能性与局限性
Agnieszka Pawlak,Jakub Stefanowicz,Zofia Kotkowska et al.
Agnieszka Pawlak et al.
Background: Synaptic pruning is a critical neurodevelopmental process that eliminates redundant or weak synaptic connections to optimize brain circuitry. In schizophrenia, converging evidence from imaging, genetic, and po...
AMPA receptors in the evolving synapse: structure, function, and disease implications [0.03%]
演化的突触中的AMPA受体：结构、功能及疾病影响
Fleming Francis,Dewan Chettri,Deepak Nair
Fleming Francis
Synapses, once considered static conduits for neuronal signals, are now recognized as dynamic, multifunctional structures critical to brain function, plasticity, and disease. This evolving understanding has highlighted the tripartite nature...
Baptiste Libé-Philippot
Baptiste Libé-Philippot
The human brain's increased cognitive abilities are underpinned by evolutionary adaptations at the molecular, cellular, and circuit levels of neural structures. This perspective explores how protracted neuronal development and divergent cel...
João Rodrigo de Oliveira,Janine I Rossato,Johseph P G Souza et al.
João Rodrigo de Oliveira et al.
Non-reinforced reactivation destabilizes spatial memory in the Morris water maze (MWM), triggering reconsolidation, a protein synthesis-dependent process that restabilizes reactivated memories. PKMζ is a constitutively active, atypical PKC...
Morphological variability may limit single-cell specificity to electric field stimulation [0.03%]
形态变异性可能限制单细胞对电场刺激的特异性反应
Daniel Trotter,Aref Pariz,Axel Hutt et al.
Daniel Trotter et al.
Introduction: Non-invasive brain stimulation techniques, widely used to manipulate neural excitability and behavior, are well studied at the meso- and macroscopic scales. However, less is known about their specificity at ...
Differential Ca2+ handling by isolated synaptic and non-synaptic mitochondria: roles of Ca2+ buffering and efflux [0.03%]
分离的突触和非突触线粒体的钙离子处理差异：钙缓冲和流出的作用
Jyotsna Mishra,Kyle Bevers,Keguo Li et al.
Jyotsna Mishra et al.
Mitochondria regulate intracellular calcium ion (Ca2+) signaling by a fine-tuned process of mitochondrial matrix (m) Ca2+ influx, mCa2+ buffering (sequestration) and mCa2+ release (Ca2+ efflux). This process is critically important in the n...
A novel peptide inhibitor of TRPM2 channels improves recovery of memory function following traumatic brain injury [0.03%]
一种新型的TRPM2通道肽抑制剂可改善创伤性脑损伤后的记忆功能恢复作用
James E Orfila,Robert M Dietz,Christian Schroeder et al.
James E Orfila et al.
Traumatic Brain Injury (TBI) is a leading cause of mortality and morbidity in adults and can lead to long-term disability, including cognitive and motor deficits. Despite advances in research, there are currently no pharmacological interven...
High frequency stimulation activates hot spots of spontaneous synaptic transmission [0.03%]
高频刺激激活自发性突触传递的热点
Herson Astacio,Maria Bykhovskaia
Herson Astacio
Neuronal transmitters are released at the morphological specializations known as active zones (AZs). Transmitters can be released either in response to a stimulus or spontaneously, and spontaneous transmission is a vital component of neuron...