João Rodrigo de Oliveira,Janine I Rossato,Johseph P G Souza et al.
João Rodrigo de Oliveira et al.
Non-reinforced reactivation destabilizes spatial memory in the Morris water maze (MWM), triggering reconsolidation, a protein synthesis-dependent process that restabilizes reactivated memories. PKMζ is a constitutively active, atypical PKC...
Morphological variability may limit single-cell specificity to electric field stimulation [0.03%]
形态变异性可能限制单细胞对电场刺激的特异性反应
Daniel Trotter,Aref Pariz,Axel Hutt et al.
Daniel Trotter et al.
Introduction: Non-invasive brain stimulation techniques, widely used to manipulate neural excitability and behavior, are well studied at the meso- and macroscopic scales. However, less is known about their specificity at ...
Differential Ca2+ handling by isolated synaptic and non-synaptic mitochondria: roles of Ca2+ buffering and efflux [0.03%]
分离的突触和非突触线粒体的钙离子处理差异：钙缓冲和流出的作用
Jyotsna Mishra,Kyle Bevers,Keguo Li et al.
Jyotsna Mishra et al.
Mitochondria regulate intracellular calcium ion (Ca2+) signaling by a fine-tuned process of mitochondrial matrix (m) Ca2+ influx, mCa2+ buffering (sequestration) and mCa2+ release (Ca2+ efflux). This process is critically important in the n...
A novel peptide inhibitor of TRPM2 channels improves recovery of memory function following traumatic brain injury [0.03%]
一种新型的TRPM2通道肽抑制剂可改善创伤性脑损伤后的记忆功能恢复作用
James E Orfila,Robert M Dietz,Christian Schroeder et al.
James E Orfila et al.
Traumatic Brain Injury (TBI) is a leading cause of mortality and morbidity in adults and can lead to long-term disability, including cognitive and motor deficits. Despite advances in research, there are currently no pharmacological interven...
High frequency stimulation activates hot spots of spontaneous synaptic transmission [0.03%]
高频刺激激活自发性突触传递的热点
Herson Astacio,Maria Bykhovskaia
Herson Astacio
Neuronal transmitters are released at the morphological specializations known as active zones (AZs). Transmitters can be released either in response to a stimulus or spontaneously, and spontaneous transmission is a vital component of neuron...
A spatial model of autophosphorylation of CaMKII predicts that the lifetime of phospho-CaMKII after induction of synaptic plasticity is greatly prolonged by CaM-trapping [0.03%]
一个对CaMKII自磷酸化的空间模型预测了由钙调素捕获所导致的突触可塑性引发后磷酰化CaMKII寿命大大延长的现象
Thomas M Bartol,Mariam Ordyan,Terrence J Sejnowski et al.
Thomas M Bartol et al.
Long-term potentiation (LTP) is a biochemical process that underlies learning in excitatory glutamatergic synapses in the Central Nervous System (CNS). A critical early driver of LTP is autophosphorylation of the abundant postsynaptic enzym...
Postsynaptic spiking determines anti-Hebbian LTD in visual cortex basket cells [0.03%]
突触后动作电位决定了视觉皮层篮细胞的反赫布长时程抑制
Christina Y C Chou,Wouter J Droogers,Txomin Lalanne et al.
Christina Y C Chou et al.
Long-term plasticity at pyramidal cell to basket cell (PC → BC) synapses is important for the functioning of cortical microcircuits. It is well known that at neocortical PC → PC synapses, dendritic calcium (Ca2+) dynamics signal coinciden...
β-adrenergic receptor-induced E-S potentiation in the dorsal and ventral hippocampus [0.03%]
背侧和腹侧海马区肾上腺素能受体诱导的E-S易化现象
George Trompoukis,Athina Miliou,Costas Papatheodoropoulos
George Trompoukis
β-adrenergic receptors (β-ARs) play a critical role in modulating learning, memory, emotionality, and long-term synaptic plasticity. Recent studies indicate that β-ARs are necessary for long-term potentiation (LTP) induction in the ventr...
Editorial: Role of protein palmitoylation in synaptic plasticity and neuronal differentiation, volume II [0.03%]
编辑部：蛋白质棕榈酰化在突触可塑性和神经元分化中的作用（第二卷）
Kevin P Koster,William N Green
Kevin P Koster
Amanda R McFarlan,Isabella Gomez,Christina Y C Chou et al.
Amanda R McFarlan et al.
Short-term plasticity is an important feature in the brain for shaping neural dynamics and for information processing. Short-term plasticity is known to depend on many factors including brain region, cortical layer, and cell type. Here we f...