Increased synaptic turnover in injured cortical axons: exploring the role of SARM1 ablation [0.03%]
损伤皮层轴突中突触周转增加：探讨SARM1缺失的作用
Ensieh Izadi,William Bennett,Jessica Collins et al.
Ensieh Izadi et al.
Introduction: Programmed axon degeneration significantly affects neural connectivity, however, the underlying mechanisms remain poorly understood, particularly in cortical regions. Sterile Alpha and TIR motif-containing p...
Enhanced information processing in the human neocortex: cellular mechanisms and translational perspectives [0.03%]
人新皮层的信息处理增强：细胞机制和转化视角
Manuela Tore,Laura Monni,Alessio Di Clemente et al.
Manuela Tore et al.
Understanding the sophisticated cognitive abilities of the human brain requires understanding its cellular and synaptic components. While rodent studies provide foundational knowledge, recent research using freshly resected human neocortica...
Group I metabotropic glutamate receptors differentially modulate excitatory transmission across interneuron types in the human cortex [0.03%]
人脑皮层中I组代谢型谷氨酸受体通过不同类型中间神经元差异化调节兴奋性传递
Joanna Grace Sandle,Gábor Molnár,Martin Tóth et al.
Joanna Grace Sandle et al.
Introduction: Group I metabotropic glutamate receptors (mGluRs) play a critical role in regulating neuronal excitability, synaptic strength, and cortical network activity. Although their physiological functions and involv...
Spatial characterization of backpropagating action potential-evoked Ca2+ signals in human cortical layer 2/3 pyramidal neurons [0.03%]
人类皮层2/3层锥体神经元中，传入动作电位诱发的钙信号的时空特征分析
Ildikó Szöts,Martin Tóth,Csongor Ludányi et al.
Ildikó Szöts et al.
Introduction: In pyramidal neurons, backpropagating action potentials (bAPs) activate voltage-gated calcium channels (VGCCs), producing compartment-specific dendritic Ca2+ transients. While extensively characterized in ro...
Convergence and divergence of molecular mechanisms in Hebbian and homeostatic plasticity [0.03%]
海布和稳态可塑性分子机制的一致性和相异之处
Kira M Feighan,Harshit K Thakare,Stephen D Glasgow et al.
Kira M Feighan et al.
The umbrella of synaptic plasticity includes associative, activity-dependent alterations in synaptic strength that are thought to underlie learning and memory, and negative feedback that stabilizes network activity, termed Hebbian and homeo...
Evolutionary neuroeconomic adaptations of fast-spiking neurons in the human neocortex [0.03%]
人类新皮层快速spiking神经元的神经经济学适应性进化
Viktor Szegedi,Abdennour Douida,Gábor Hutóczki et al.
Viktor Szegedi et al.
Homo sapiens has evolved a large and complex neocortex that underlies advanced cognitive capabilities. Neural computation, however, is inherently energy-intensive, and evolutionary pressures have shaped mechanisms that optimize both computa...
Aging and Alzheimer's: the critical role of mitochondrial dysfunction and synaptic alterations [0.03%]
衰老与阿尔茨海默病：线粒体功能障碍和突触改变的关键作用
Pinky,Zitin Wali,Neha et al.
Pinky et al.
Alzheimer's disease is a progressive neurodegenerative disorder marked by cognitive decline, accumulation of amyloid-β plaques and neurofibrillary tangles, synaptic dysfunction, and mitochondrial impairment. Despite multiple therapeutic st...
Synaptic transmission in supragranular layers of the human cortex - comparative review of structure, function, and plasticity [0.03%]
人脑皮层 supra-granular层的突触传递-结构、功能和可塑性的比较综述
Amelie Eichler,Pia Kruse,Charlotte Schob et al.
Amelie Eichler et al.
Synapses are the highly specialized connection sites between neurons enabling the establishment of complex neuronal networks. As highly plastic structures, synapses collocate both the transmission and storage of information, which is an ess...
From microelectrode arrays to all-optical and multimodal neural interfaces: emerging platforms for spatiotemporal interrogation of in vitro neural circuits [0.03%]
从微电极阵列到全光学和多模态神经接口：离体神经回路时空探测的新兴平台
Song Wang,Sarah Gordon,Chris French et al.
Song Wang et al.
Understanding how synaptic interactions lead to circuit dynamics for neural computation requires experimental tools that can both observe and perturb neuronal activity across spatial and temporal scales. Microelectrode arrays (MEAs) provide...
GABAB receptors negatively modulate excitatory plasticity at the mossy fiber synapse onto parvalbumin-expressing basket and axo-axonic cells in the dentate gyrus [0.03%]
GABAＢ受体通过调节内侧齿状回胆碱能 mossy fiber-granule cell环路的长时程增强来抑制颗粒细胞兴奋性
Rita M Loureiro,Sam A Booker,Akos Kulik et al.
Rita M Loureiro et al.
Introduction: GABAB receptors (GABABRs) are important modulators of neuronal excitability, synaptic transmission and plasticity in principal cells (PCs). While at the cellular level they can inhibit synaptic transmission ...