The biological alterations of synapse/synapse formation in sepsis-associated encephalopathy [0.03%]
脓毒症相关性脑病突触/突触形成发生的生物改变
Chuan Tang,Ye Jin,Huan Wang
Chuan Tang
Sepsis-associated encephalopathy (SAE) is a common complication caused by sepsis, and is responsible for increased mortality and poor outcomes in septic patients. Neurological dysfunction is one of the main manifestations of SAE patients. P...
Effects of the clathrin inhibitor Pitstop-2 on synaptic vesicle recycling at a central synapse in vivo [0.03%]
筐蛋白抑制剂Pitstop-2对体内中枢突触的突触小泡循环的影响
Alp Paksoy,Simone Hoppe,Yvette Dörflinger et al.
Alp Paksoy et al.
Four modes of endocytosis and subsequent synaptic vesicle (SV) recycling have been described at the presynapse to ensure the availability of SVs for synaptic release. However, it is unclear to what extend these modes operate under physiolog...
Serotonin as a volume transmission signal in the "simple nervous system" of mollusks: From axonal guidance to behavioral orchestration [0.03%]
甲壳类动物"简单神经系统"中的血清素作为容积传输信号：从轴突引导到行为协调
Elena E Voronezhskaya
Elena E Voronezhskaya
Membrane lipid rafts are required for AMPA receptor tyrosine phosphorylation [0.03%]
膜脂筏对AMP阿酸盐受体酪氨酸磷酸化是必需的
Takashi Hayashi
Takashi Hayashi
Membrane lipid rafts are sphingolipids and cholesterol-enriched membrane microdomains, which form a center for the interaction or assembly of palmitoylated signaling molecules, including Src family non-receptor type protein tyrosine kinases...
Neocortical layer 5 subclasses: From cellular properties to roles in behavior [0.03%]
新皮层第5亚类：从细胞特性到行为中的作用
Sara Moberg,Naoya Takahashi
Sara Moberg
Layer 5 (L5) serves as the main output layer of cortical structures, where long-range projecting pyramidal neurons broadcast the columnar output to other cortical and extracortical regions of the brain. L5 pyramidal neurons are grouped into...
Fereshteh S Nugent,Alfredo Kirkwood,Carl R Lupica et al.
Fereshteh S Nugent et al.
Protein phosphatase-1 inhibitor-2 promotes PP1 γ positive regulation of synaptic transmission [0.03%]
蛋白磷酸酶-1抑制剂-2能够促进PP1γ对突触传递的积极作用
Karl Foley,Haider Altimimi,Hailong Hou et al.
Karl Foley et al.
Inhibitor-2 (I-2) is a prototypic inhibitor of protein phosphatase-1 (PP1), a major serine-threonine phosphatase that regulates synaptic plasticity and learning and memory. Although I-2 is a potent inhibitor of PP1 in vitro, our previous wo...
Heightened sympathetic neuron activity and altered cardiomyocyte properties in spontaneously hypertensive rats during the postnatal period [0.03%]
自发性高血压大鼠产后交感神经元活性增强和心肌细胞特性改变
Marián Haburčák,Joshua Harrison,Melda M Buyukozturk et al.
Marián Haburčák et al.
The Spontaneously Hypertensive Rat (SHR) has increased sympathetic drive to the periphery that precedes and contributes to the development of high blood pressure, making it a useful model for the study of neurogenic hypertension. Comparison...
Palmitoylation of A-kinase anchoring protein 79/150 modulates its nanoscale organization, trafficking, and mobility in postsynaptic spines [0.03%]
棕榈酰化调控A-蛋白激酶锚定蛋白79/150在后突触棘中的纳米级排列、转运和移动性
Xiaobing Chen,Kevin C Crosby,Austin Feng et al.
Xiaobing Chen et al.
A-kinase anchoring protein 79-human/150-rodent (AKAP79/150) organizes signaling proteins to control synaptic plasticity. AKAP79/150 associates with the plasma membrane and endosomes through its N-terminal domain that contains three polybasi...
Cai Qi,Li-Da Luo,Irena Feng et al.
Cai Qi et al.
Synapses are the basic units for information processing and storage in the nervous system. It is only when the synaptic connection is established, that it becomes meaningful to discuss the structure and function of a circuit. In humans, our...