Early life adversity impaired dorsal striatal synaptic transmission and behavioral adaptability to appropriate action selection in a sex-dependent manner [0.03%]
早期生活应激通过性别依赖的方式损害纹状体可塑性及行为适应性
Gregory de Carvalho,Sheraz Khoja,Mulatwa T Haile et al.
Gregory de Carvalho et al.
Early life adversity (ELA) is a major health burden in the United States, with 62% of adults reporting at least one adverse childhood experience. These experiences during critical stages of brain development can perturb the development of n...
Recording plasticity in neuronal activity in the rodent intrinsic cardiac nervous system using calcium imaging techniques [0.03%]
钙成像技术在记录啮齿动物心脏自主神经系统神经元活动的可塑性中的应用研究
Joscelin E G Smith,Jesse L Ashton,Liam P Argent et al.
Joscelin E G Smith et al.
The intrinsic cardiac nervous system (ICNS) is composed of interconnected clusters of neurons called ganglionated plexi (GP) which play a major role in controlling heart rate and rhythm. The function of these neurons is particularly importa...
Burak Uzay,Ege T Kavalali
Burak Uzay
Synaptic neurotransmitter release is an evolutionarily conserved process that mediates rapid information transfer between neurons as well as several peripheral tissues. Release of neurotransmitters are ensured by successive events such as s...
The effect of single-cell knockout of Fragile X Messenger Ribonucleoprotein on synaptic structural plasticity [0.03%]
脆性X氏甲基 RNA 结合蛋白单细胞敲除对突触结构可塑性的影响
Marie Gredell,Ju Lu,Yi Zuo
Marie Gredell
Fragile X Syndrome (FXS) is the best-known form of inherited intellectual disability caused by the loss-of-function mutation in a single gene. The FMR1 gene mutation abolishes the expression of Fragile X Messenger Ribonucleoprotein (FMRP), ...
GluN2B-NMDAR subunit contribution on synaptic plasticity: A phenomenological model for CA3-CA1 synapses [0.03%]
GluN2B-NMDAR亚基对突触可塑性的贡献作用：海马CA3-CA1突触的神经元模型研究
Justinas J Dainauskas,Hélène Marie,Michele Migliore et al.
Justinas J Dainauskas et al.
Synaptic plasticity is believed to be a key mechanism underlying learning and memory. We developed a phenomenological N-methyl-D-aspartate (NMDA) receptor-based voltage-dependent synaptic plasticity model for synaptic modifications at hippo...
Bringing synapses into focus: Recent advances in synaptic imaging and mass-spectrometry for studying synaptopathy [0.03%]
聚焦突触的研究：突触成像和质谱分析的最新进展在突触病变研究中的应用
Nicole Hindley,Anna Sanchez Avila,Christopher Henstridge
Nicole Hindley
Synapses are integral for healthy brain function and are becoming increasingly recognized as key structures in the early stages of brain disease. Understanding the pathological processes driving synaptic dysfunction will unlock new therapeu...
Alzheimer's disease as a synaptopathy: Evidence for dysfunction of synapses during disease progression [0.03%]
阿尔茨海默病的突触病变：疾病进展期间突触功能障碍的证据
Soraya Meftah,Jian Gan
Soraya Meftah
The synapse has consistently been considered a vulnerable and critical target within Alzheimer's disease, and synapse loss is, to date, one of the main biological correlates of cognitive decline within Alzheimer's disease. This occurs prior...
Tomoe Ishikawa,Ayako Wendy Ishikawa,Athanasia Papoutsi et al.
Tomoe Ishikawa et al.
Julianna Goenaga,Alfonso Araque,Paulo Kofuji et al.
Julianna Goenaga et al.
Glia are as numerous in the brain as neurons and widely known to serve supportive roles such as structural scaffolding, extracellular ionic and neurotransmitter homeostasis, and metabolic support. However, over the past two decades, several...
mGluR-dependent plasticity in rodent models of Alzheimer's disease [0.03%]
基于代谢型谷氨酸受体的可塑性在阿尔茨海默病动物模型中的作用
Gonzalo Valdivia,Alvaro O Ardiles,Abimbola Idowu et al.
Gonzalo Valdivia et al.
Long-term potentiation (LTP) and depression (LTD) are currently the most comprehensive models of synaptic plasticity models to subserve learning and memory. In the CA1 region of the hippocampus LTP and LTD can be induced by the activation o...