Gary C Mouradian Jr,Matthew A Cooper
Gary C Mouradian Jr
Tonic activation of GABAB receptors via GAT-3 mediated GABA release reduces network activity in the developing somatosensory cortex in GAD67-GFP mice [0.03%]
GAD67-GFP小鼠发育感觉皮层中的GABAB受体通过GAT-3介导的GABA释放被激动从而减少网络活性
Timo Ueberbach,Clara A Simacek,Irmgard Tegeder et al.
Timo Ueberbach et al.
The efficiency of neocortical information processing critically depends on the balance between the glutamatergic (excitatory, E) and GABAergic (inhibitory, I) synaptic transmission. A transient imbalance of the E/I-ratio during early develo...
Visualizing the triheteromeric N-methyl-D-aspartate receptor subunit composition [0.03%]
视觉化三聚体N-甲基-D-天冬氨酸受体亚基组成
Stephen Beesley,Akash Gunjan,Sanjay S Kumar
Stephen Beesley
N-methyl-D-aspartate receptors (NMDARs) are one of three ligand-gated ionotropic channels that transduce the effects of neurotransmitter glutamate at excitatory synapses within the central nervous system. Their ability to influx Ca2+ into c...
Cell-autonomous and differential endocannabinoid signaling impacts the development of presynaptic retinal ganglion cell axon connectivity in vivo [0.03%]
自体细胞的内源性大麻素信号对视网膜节细胞轴突在体连接发育的影响是不同的
Rodrigo Del Rio Jr,Rosa G Serrano,Eric Gomez et al.
Rodrigo Del Rio Jr et al.
Cannabis exposure during gestation evokes significant molecular modifications to neurodevelopmental programs leading to neurophysiological and behavioral abnormalities in humans. The main neuronal receptor for Δ9-tetrahydrocannabinol (THC)...
Jianwen Lin,Wenxin Liu,Jing Guan et al.
Jianwen Lin et al.
Psychiatric disorders are among the leading causes of global health burden, with depression and anxiety being the most disabling subtypes. The two common disorders, depression and anxiety, usually coexist and are pathologically polygenic wi...
Metformin inhibits spontaneous excitatory postsynaptic currents in spinal dorsal cord neurons from paclitaxel-treated rats [0.03%]
二甲双胍可抑制紫杉醇所致大鼠脊髓背角神经元的自发兴奋性突触后电流
Ting-Ting Liu,Chun-Yu Qiu,Wang-Ping Hu
Ting-Ting Liu
Introduction: Cancer patients treated with paclitaxel often develop chemotherapy-induced peripheral neuropathy, which has not been effectively treated with drugs. The anti-diabetic drug metformin is effective in the treat...
Fereshteh S Nugent,Ka Wan Li,Lu Chen
Fereshteh S Nugent
Multiple modulatory roles of serotonin in chronic pain and injury-related anxiety [0.03%]
血清素在慢性疼痛和损伤相关焦虑中的多种调节作用
Shun Hao,Wantong Shi,Weiqi Liu et al.
Shun Hao et al.
Chronic pain is long-lasting pain that often persists during chronic diseases or after recovery from disease or injury. It often causes serious side effects, such as insomnia, anxiety, or depression which negatively impacts the patient's ov...
Cryo-EM tomography and automatic segmentation delineate modular structures in the postsynaptic density [0.03%]
cryo-EM断层扫描和自动分割界定突触后密度的模块化结构
Jae Hoon Jung,Xiaobing Chen,Thomas S Reese
Jae Hoon Jung
Postsynaptic densities (PSDs) are large protein complexes associated with the postsynaptic membrane of excitatory synapses important for synaptic function including plasticity. Conventional electron microscopy (EM) typically depicts PSDs as...
Inhibitory hippocampus-medial septum projection controls locomotion and exploratory behavior [0.03%]
抑制性海马-腹内侧隔核环路调控自主活动和探究行为
Yuh-Tarng Chen,Rachel Arano,Jun Guo et al.
Yuh-Tarng Chen et al.
Although the hippocampus is generally considered a cognitive center for spatial representation, learning, and memory, increasing evidence supports its roles in regulating locomotion. However, the neuronal mechanisms of the hippocampal regul...