Distinctive biophysical features of human cell-types: insights from studies of neurosurgically resected brain tissue [0.03%]
人细胞类型的独特的生物物理特征：来自神经外科切除脑组织研究的启示
Homeira Moradi Chameh,Madeleine Falby,Mandana Movahed et al.
Homeira Moradi Chameh et al.
Electrophysiological characterization of live human tissue from epilepsy patients has been performed for many decades. Although initially these studies sought to understand the biophysical and synaptic changes associated with human epilepsy...
Ben Yang,Roman A Romanov,Jinbin Xu et al.
Ben Yang et al.
Jung-Hwa Tao-Cheng,Sandra L Moreira,Christine A Winters et al.
Jung-Hwa Tao-Cheng et al.
The synaptic cleft is the extracellular part of the synapse, bridging the pre- and postsynaptic membranes. The geometry and molecular organization of the cleft is gaining increased attention as an important determinant of synaptic efficacy....
Clive R Bramham,Volkmar Lessmann,Anthony J Hannan et al.
Clive R Bramham et al.
Ana P Crestani,Ana Cicvaric,Adelaide P Yiu
Ana P Crestani
Shared and divergent principles of synaptic transmission between cortical excitatory neurons in rodent and human brain [0.03%]
啮齿动物和人类大脑中兴奋性神经元之间的突触传递的共同原则与分歧原理
Christiaan P J de Kock,Dirk Feldmeyer
Christiaan P J de Kock
Information transfer between principal neurons in neocortex occurs through (glutamatergic) synaptic transmission. In this focussed review, we provide a detailed overview on the strength of synaptic neurotransmission between pairs of excitat...
Synaptic alterations and neuronal firing in human epileptic neocortical excitatory networks [0.03%]
人类癫痫皮层兴奋性神经网络中的突触变化及神经元放电现象
Réka Bod,Kinga Tóth,Nour Essam et al.
Réka Bod et al.
Epilepsy is a prevalent neurological condition, with underlying neuronal mechanisms involving hyperexcitability and hypersynchrony. Imbalance between excitatory and inhibitory circuits, as well as histological reorganization are relatively ...
Jae Hoon Jung,Noreen E Reist,Sebastian Doniach
Jae Hoon Jung
Synapse-specific diversity of distinct postsynaptic GluN2 subtypes defines transmission strength in spinal lamina I [0.03%]
脊髓层I区特定的-postsynaptic GluN2亚型的多样性定义了递质释放强度
Graham M Pitcher,Livia Garzia,A Sorana Morrissy et al.
Graham M Pitcher et al.
The unitary postsynaptic response to presynaptic quantal glutamate release is the fundamental basis of excitatory information transfer between neurons. The view, however, of individual glutamatergic synaptic connections in a population as h...
Rethinking the network determinants of motor disability in Parkinson's disease [0.03%]
帕金森病运动残疾的网络决定因素的新认识
Dalton James Surmeier,Shenyu Zhai,Qiaoling Cui et al.
Dalton James Surmeier et al.
For roughly the last 30 years, the notion that striatal dopamine (DA) depletion was the critical determinant of network pathophysiology underlying the motor symptoms of Parkinson's disease (PD) has dominated the field. While the basal gangl...