Bringing synapses into focus: Recent advances in synaptic imaging and mass-spectrometry for studying synaptopathy [0.03%]
聚焦突触的研究：突触成像和质谱分析的最新进展在突触病变研究中的应用
Nicole Hindley,Anna Sanchez Avila,Christopher Henstridge
Nicole Hindley
Synapses are integral for healthy brain function and are becoming increasingly recognized as key structures in the early stages of brain disease. Understanding the pathological processes driving synaptic dysfunction will unlock new therapeu...
Alzheimer's disease as a synaptopathy: Evidence for dysfunction of synapses during disease progression [0.03%]
阿尔茨海默病的突触病变：疾病进展期间突触功能障碍的证据
Soraya Meftah,Jian Gan
Soraya Meftah
The synapse has consistently been considered a vulnerable and critical target within Alzheimer's disease, and synapse loss is, to date, one of the main biological correlates of cognitive decline within Alzheimer's disease. This occurs prior...
Tomoe Ishikawa,Ayako Wendy Ishikawa,Athanasia Papoutsi et al.
Tomoe Ishikawa et al.
Julianna Goenaga,Alfonso Araque,Paulo Kofuji et al.
Julianna Goenaga et al.
Glia are as numerous in the brain as neurons and widely known to serve supportive roles such as structural scaffolding, extracellular ionic and neurotransmitter homeostasis, and metabolic support. However, over the past two decades, several...
mGluR-dependent plasticity in rodent models of Alzheimer's disease [0.03%]
基于代谢型谷氨酸受体的可塑性在阿尔茨海默病动物模型中的作用
Gonzalo Valdivia,Alvaro O Ardiles,Abimbola Idowu et al.
Gonzalo Valdivia et al.
Long-term potentiation (LTP) and depression (LTD) are currently the most comprehensive models of synaptic plasticity models to subserve learning and memory. In the CA1 region of the hippocampus LTP and LTD can be induced by the activation o...
María Verónica Baez,Julien P Dupuis,Gaston Diego Calfa
María Verónica Baez
Memory retrieval, reconsolidation, and extinction: Exploring the boundary conditions of post-conditioning cue exposure [0.03%]
记忆提取、再巩固与消退：后处理线索接触的边界条件探索
Nicole C Ferrara,Janine L Kwapis,Sydney Trask
Nicole C Ferrara
Following fear conditioning, behavior can be reduced by giving many CS-alone presentations in a process known as extinction or by presenting a few CS-alone presentations and interfering with subsequent memory reconsolidation. While the two ...
Triose-phosphate isomerase deficiency is associated with a dysregulation of synaptic vesicle recycling in Drosophila melanogaster [0.03%]
果蝇中磷酸丙糖异构酶缺乏与突触囊泡循环的失调有关
Aelfwin Stone,Oliver Cujic,Angel Rowlett et al.
Aelfwin Stone et al.
Introduction: Numerous neurodegenerative diseases are associated with neuronal dysfunction caused by increased redox stress, often linked to aberrant production of redox-active molecules such as nitric oxide (NO) or oxyge...
Zhihui Liu,Richard Sando,Bo Zhang et al.
Zhihui Liu et al.
Segregation of D1 and D2 dopamine receptors in the striatal direct and indirect pathways: An historical perspective [0.03%]
纹状体直接通路和间接通路中D1型和D2型多巴胺受体的分离：一种历史视角
Charles R Gerfen
Charles R Gerfen
The direct and indirect striatal pathways form a cornerstone of the circuits of the basal ganglia. Dopamine has opponent affects on the function of these pathways due to the segregation of the D1- and D2-dopamine receptors in the spiny proj...