Elena M Boggio,Giuseppina Lonetti,Tommaso Pizzorusso et al.
Elena M Boggio et al.
There is mounting evidence showing that the structural and molecular organization of synaptic connections is affected both in human patients and in animal models of neurological and psychiatric diseases. As a consequence of these experiment...
NMDAR-Mediated Calcium Transients Elicited by Glutamate Co-Release at Developing Inhibitory Synapses [0.03%]
由谷氨酸共释放引发的在发育期抑制性突触上NMDAR介导的钙瞬变现象
Abigail Kalmbach,Paul H M Kullmann,Karl Kandler
Abigail Kalmbach
Before hearing onset, the topographic organization of the inhibitory sound localization pathway from the medial nucleus of the trapezoid body (MNTB) to the lateral superior olive (LSO) is refined by means of synaptic silencing and strengthe...
Transcranial magnetic stimulation provides means to assess cortical plasticity and excitability in humans with fragile x syndrome and autism spectrum disorder [0.03%]
经颅磁刺激能提供评估脆性X综合征和自闭症谱系障碍患者皮质可塑性和兴奋性的方法
Lindsay Oberman,Fritz Ifert-Miller,Umer Najib et al.
Lindsay Oberman et al.
Fragile X Syndrome (FXS) is the most common heritable cause of intellectual disability. In vitro electrophysiologic data from mouse models of FXS suggest that loss of fragile X mental retardation protein affects intracortical excitability a...
Claudia Clopath,Wulfram Gerstner
Claudia Clopath
A phenomenological model of synaptic plasticity is able to account for a large body of experimental data on spike-timing-dependent plasticity (STDP). The basic ingredient of the model is the correlation of presynaptic spike arrival with pos...
Chronic stress effects on hippocampal structure and synaptic function: relevance for depression and normalization by anti-glucocorticoid treatment [0.03%]
慢性应激对海马结构和突触功能的影响及抗皮质类固醇治疗的逆转作用与抑郁症的关系
Harmen J Krugers,Paul J Lucassen,Henk Karst et al.
Harmen J Krugers et al.
Exposure of an organism to environmental challenges activates two hormonal systems that help the organism to adapt. As part of this adaptational process, brain processes are changed such that appropriate behavioral strategies are selected t...
Cortico-striatal spike-timing dependent plasticity after activation of subcortical pathways [0.03%]
皮层下通路激活后的皮层-纹状体时间依赖性可塑性
Jan M Schulz,Peter Redgrave,John N J Reynolds
Jan M Schulz
Cortico-striatal spike-timing dependent plasticity (STDP) is modulated by dopamine in vitro. The present study investigated STDP in vivo using alternative procedures for modulating dopaminergic inputs. Postsynaptic potentials (PSP) were evo...
GABAergic activities control spike timing- and frequency-dependent long-term depression at hippocampal excitatory synapses [0.03%]
GABA能活动控制海马区兴奋性突触的长时程抑制中的尖峰时间依赖和频率依赖过程
Makoto Nishiyama,Kazunobu Togashi,Takeshi Aihara et al.
Makoto Nishiyama et al.
GABAergic interneuronal network activities in the hippocampus control a variety of neural functions, including learning and memory, by regulating θ and γ oscillations. How these GABAergic activities at pre- and postsynaptic sites of hippo...
Spike-timing dependent plasticity beyond synapse - pre- and post-synaptic plasticity of intrinsic neuronal excitability [0.03%]
基于突触的 spike-timing 依赖可塑性及其扩展：输入阻力和钠电流的动力学可塑性
Dominique Debanne,Mu-Ming Poo
Dominique Debanne
Long-lasting plasticity of synaptic transmission is classically thought to be the cellular substrate for information storage in the brain. Recent data indicate however that it is not the whole story and persistent changes in the intrinsic n...
Sharing vesicles between central presynaptic terminals: implications for synaptic function [0.03%]
中枢前突触终端之间共享囊泡及其对突触功能的影响
Kevin Staras,Tiago Branco
Kevin Staras
Presynaptic terminals in hippocampal neurons house functionally distinct vesicle pools, the size, structure and biochemical features of which are major determinants of presynaptic strength and performance. In classical models of synaptic fu...
Robert C Froemke,Dominique Debanne,Guo-Qiang Bi
Robert C Froemke
Spike-timing-dependent plasticity (STDP) has attracted considerable experimental and theoretical attention over the last decade. In the most basic formulation, STDP provides a fundamental unit - a spike pair - for quantifying the induction ...