Metformin inhibits spontaneous excitatory postsynaptic currents in spinal dorsal cord neurons from paclitaxel-treated rats [0.03%]
二甲双胍可抑制紫杉醇所致大鼠脊髓背角神经元的自发兴奋性突触后电流
Ting-Ting Liu,Chun-Yu Qiu,Wang-Ping Hu
Ting-Ting Liu
Introduction: Cancer patients treated with paclitaxel often develop chemotherapy-induced peripheral neuropathy, which has not been effectively treated with drugs. The anti-diabetic drug metformin is effective in the treat...
Fereshteh S Nugent,Ka Wan Li,Lu Chen
Fereshteh S Nugent
Multiple modulatory roles of serotonin in chronic pain and injury-related anxiety [0.03%]
血清素在慢性疼痛和损伤相关焦虑中的多种调节作用
Shun Hao,Wantong Shi,Weiqi Liu et al.
Shun Hao et al.
Chronic pain is long-lasting pain that often persists during chronic diseases or after recovery from disease or injury. It often causes serious side effects, such as insomnia, anxiety, or depression which negatively impacts the patient's ov...
Cryo-EM tomography and automatic segmentation delineate modular structures in the postsynaptic density [0.03%]
cryo-EM断层扫描和自动分割界定突触后密度的模块化结构
Jae Hoon Jung,Xiaobing Chen,Thomas S Reese
Jae Hoon Jung
Postsynaptic densities (PSDs) are large protein complexes associated with the postsynaptic membrane of excitatory synapses important for synaptic function including plasticity. Conventional electron microscopy (EM) typically depicts PSDs as...
Inhibitory hippocampus-medial septum projection controls locomotion and exploratory behavior [0.03%]
抑制性海马-腹内侧隔核环路调控自主活动和探究行为
Yuh-Tarng Chen,Rachel Arano,Jun Guo et al.
Yuh-Tarng Chen et al.
Although the hippocampus is generally considered a cognitive center for spatial representation, learning, and memory, increasing evidence supports its roles in regulating locomotion. However, the neuronal mechanisms of the hippocampal regul...
Early life adversity impaired dorsal striatal synaptic transmission and behavioral adaptability to appropriate action selection in a sex-dependent manner [0.03%]
早期生活应激通过性别依赖的方式损害纹状体可塑性及行为适应性
Gregory de Carvalho,Sheraz Khoja,Mulatwa T Haile et al.
Gregory de Carvalho et al.
Early life adversity (ELA) is a major health burden in the United States, with 62% of adults reporting at least one adverse childhood experience. These experiences during critical stages of brain development can perturb the development of n...
Recording plasticity in neuronal activity in the rodent intrinsic cardiac nervous system using calcium imaging techniques [0.03%]
钙成像技术在记录啮齿动物心脏自主神经系统神经元活动的可塑性中的应用研究
Joscelin E G Smith,Jesse L Ashton,Liam P Argent et al.
Joscelin E G Smith et al.
The intrinsic cardiac nervous system (ICNS) is composed of interconnected clusters of neurons called ganglionated plexi (GP) which play a major role in controlling heart rate and rhythm. The function of these neurons is particularly importa...
Burak Uzay,Ege T Kavalali
Burak Uzay
Synaptic neurotransmitter release is an evolutionarily conserved process that mediates rapid information transfer between neurons as well as several peripheral tissues. Release of neurotransmitters are ensured by successive events such as s...
The effect of single-cell knockout of Fragile X Messenger Ribonucleoprotein on synaptic structural plasticity [0.03%]
脆性X氏甲基 RNA 结合蛋白单细胞敲除对突触结构可塑性的影响
Marie Gredell,Ju Lu,Yi Zuo
Marie Gredell
Fragile X Syndrome (FXS) is the best-known form of inherited intellectual disability caused by the loss-of-function mutation in a single gene. The FMR1 gene mutation abolishes the expression of Fragile X Messenger Ribonucleoprotein (FMRP), ...
GluN2B-NMDAR subunit contribution on synaptic plasticity: A phenomenological model for CA3-CA1 synapses [0.03%]
GluN2B-NMDAR亚基对突触可塑性的贡献作用：海马CA3-CA1突触的神经元模型研究
Justinas J Dainauskas,Hélène Marie,Michele Migliore et al.
Justinas J Dainauskas et al.
Synaptic plasticity is believed to be a key mechanism underlying learning and memory. We developed a phenomenological N-methyl-D-aspartate (NMDA) receptor-based voltage-dependent synaptic plasticity model for synaptic modifications at hippo...