Shared and divergent principles of synaptic transmission between cortical excitatory neurons in rodent and human brain [0.03%]
啮齿动物和人类大脑中兴奋性神经元之间的突触传递的共同原则与分歧原理
Christiaan P J de Kock,Dirk Feldmeyer
Christiaan P J de Kock
Information transfer between principal neurons in neocortex occurs through (glutamatergic) synaptic transmission. In this focussed review, we provide a detailed overview on the strength of synaptic neurotransmission between pairs of excitat...
Synaptic alterations and neuronal firing in human epileptic neocortical excitatory networks [0.03%]
人类癫痫皮层兴奋性神经网络中的突触变化及神经元放电现象
Réka Bod,Kinga Tóth,Nour Essam et al.
Réka Bod et al.
Epilepsy is a prevalent neurological condition, with underlying neuronal mechanisms involving hyperexcitability and hypersynchrony. Imbalance between excitatory and inhibitory circuits, as well as histological reorganization are relatively ...
Jae Hoon Jung,Noreen E Reist,Sebastian Doniach
Jae Hoon Jung
Synapse-specific diversity of distinct postsynaptic GluN2 subtypes defines transmission strength in spinal lamina I [0.03%]
脊髓层I区特定的-postsynaptic GluN2亚型的多样性定义了递质释放强度
Graham M Pitcher,Livia Garzia,A Sorana Morrissy et al.
Graham M Pitcher et al.
The unitary postsynaptic response to presynaptic quantal glutamate release is the fundamental basis of excitatory information transfer between neurons. The view, however, of individual glutamatergic synaptic connections in a population as h...
Rethinking the network determinants of motor disability in Parkinson's disease [0.03%]
帕金森病运动残疾的网络决定因素的新认识
Dalton James Surmeier,Shenyu Zhai,Qiaoling Cui et al.
Dalton James Surmeier et al.
For roughly the last 30 years, the notion that striatal dopamine (DA) depletion was the critical determinant of network pathophysiology underlying the motor symptoms of Parkinson's disease (PD) has dominated the field. While the basal gangl...
Gary C Mouradian Jr,Matthew A Cooper
Gary C Mouradian Jr
Tonic activation of GABAB receptors via GAT-3 mediated GABA release reduces network activity in the developing somatosensory cortex in GAD67-GFP mice [0.03%]
GAD67-GFP小鼠发育感觉皮层中的GABAB受体通过GAT-3介导的GABA释放被激动从而减少网络活性
Timo Ueberbach,Clara A Simacek,Irmgard Tegeder et al.
Timo Ueberbach et al.
The efficiency of neocortical information processing critically depends on the balance between the glutamatergic (excitatory, E) and GABAergic (inhibitory, I) synaptic transmission. A transient imbalance of the E/I-ratio during early develo...
Visualizing the triheteromeric N-methyl-D-aspartate receptor subunit composition [0.03%]
视觉化三聚体N-甲基-D-天冬氨酸受体亚基组成
Stephen Beesley,Akash Gunjan,Sanjay S Kumar
Stephen Beesley
N-methyl-D-aspartate receptors (NMDARs) are one of three ligand-gated ionotropic channels that transduce the effects of neurotransmitter glutamate at excitatory synapses within the central nervous system. Their ability to influx Ca2+ into c...
Cell-autonomous and differential endocannabinoid signaling impacts the development of presynaptic retinal ganglion cell axon connectivity in vivo [0.03%]
自体细胞的内源性大麻素信号对视网膜节细胞轴突在体连接发育的影响是不同的
Rodrigo Del Rio Jr,Rosa G Serrano,Eric Gomez et al.
Rodrigo Del Rio Jr et al.
Cannabis exposure during gestation evokes significant molecular modifications to neurodevelopmental programs leading to neurophysiological and behavioral abnormalities in humans. The main neuronal receptor for Δ9-tetrahydrocannabinol (THC)...
Jianwen Lin,Wenxin Liu,Jing Guan et al.
Jianwen Lin et al.
Psychiatric disorders are among the leading causes of global health burden, with depression and anxiety being the most disabling subtypes. The two common disorders, depression and anxiety, usually coexist and are pathologically polygenic wi...