Convergence and divergence of molecular mechanisms in Hebbian and homeostatic plasticity [0.03%]
海布和稳态可塑性分子机制的一致性和相异之处
Kira M Feighan,Harshit K Thakare,Stephen D Glasgow et al.
Kira M Feighan et al.
The umbrella of synaptic plasticity includes associative, activity-dependent alterations in synaptic strength that are thought to underlie learning and memory, and negative feedback that stabilizes network activity, termed Hebbian and homeo...
Evolutionary neuroeconomic adaptations of fast-spiking neurons in the human neocortex [0.03%]
人类新皮层快速spiking神经元的神经经济学适应性进化
Viktor Szegedi,Abdennour Douida,Gábor Hutóczki et al.
Viktor Szegedi et al.
Homo sapiens has evolved a large and complex neocortex that underlies advanced cognitive capabilities. Neural computation, however, is inherently energy-intensive, and evolutionary pressures have shaped mechanisms that optimize both computa...
Aging and Alzheimer's: the critical role of mitochondrial dysfunction and synaptic alterations [0.03%]
衰老与阿尔茨海默病：线粒体功能障碍和突触改变的关键作用
Pinky,Zitin Wali,Neha et al.
Pinky et al.
Alzheimer's disease is a progressive neurodegenerative disorder marked by cognitive decline, accumulation of amyloid-β plaques and neurofibrillary tangles, synaptic dysfunction, and mitochondrial impairment. Despite multiple therapeutic st...
Synaptic transmission in supragranular layers of the human cortex - comparative review of structure, function, and plasticity [0.03%]
人脑皮层 supra-granular层的突触传递-结构、功能和可塑性的比较综述
Amelie Eichler,Pia Kruse,Charlotte Schob et al.
Amelie Eichler et al.
Synapses are the highly specialized connection sites between neurons enabling the establishment of complex neuronal networks. As highly plastic structures, synapses collocate both the transmission and storage of information, which is an ess...
From microelectrode arrays to all-optical and multimodal neural interfaces: emerging platforms for spatiotemporal interrogation of in vitro neural circuits [0.03%]
从微电极阵列到全光学和多模态神经接口：离体神经回路时空探测的新兴平台
Song Wang,Sarah Gordon,Chris French et al.
Song Wang et al.
Understanding how synaptic interactions lead to circuit dynamics for neural computation requires experimental tools that can both observe and perturb neuronal activity across spatial and temporal scales. Microelectrode arrays (MEAs) provide...
GABAB receptors negatively modulate excitatory plasticity at the mossy fiber synapse onto parvalbumin-expressing basket and axo-axonic cells in the dentate gyrus [0.03%]
GABAＢ受体通过调节内侧齿状回胆碱能 mossy fiber-granule cell环路的长时程增强来抑制颗粒细胞兴奋性
Rita M Loureiro,Sam A Booker,Akos Kulik et al.
Rita M Loureiro et al.
Introduction: GABAB receptors (GABABRs) are important modulators of neuronal excitability, synaptic transmission and plasticity in principal cells (PCs). While at the cellular level they can inhibit synaptic transmission ...
Opposite serotonergic modulation of sharp waves in the dorsal and ventral hippocampus [0.03%]
海马背腹侧区锐波的相反的血清素调制作用
Charalampos L Kandilakis,Costas Papatheodoropoulos
Charalampos L Kandilakis
Serotonin plays a crucial role in regulating hippocampal network dynamics, however, its effects on sharp wave-ripples (SPWs), a pattern fundamental for memory consolidation and emotional processing, remain incompletely understood, particula...
Is it possible to prevent excessive synaptic pruning in schizophrenia? Possibilities and limitations [0.03%]
预防精神分裂症中过度的突触修剪是可能的吗？可能性与局限性
Agnieszka Pawlak,Jakub Stefanowicz,Zofia Kotkowska et al.
Agnieszka Pawlak et al.
Background: Synaptic pruning is a critical neurodevelopmental process that eliminates redundant or weak synaptic connections to optimize brain circuitry. In schizophrenia, converging evidence from imaging, genetic, and po...
AMPA receptors in the evolving synapse: structure, function, and disease implications [0.03%]
演化的突触中的AMPA受体：结构、功能及疾病影响
Fleming Francis,Dewan Chettri,Deepak Nair
Fleming Francis
Synapses, once considered static conduits for neuronal signals, are now recognized as dynamic, multifunctional structures critical to brain function, plasticity, and disease. This evolving understanding has highlighted the tripartite nature...
Baptiste Libé-Philippot
Baptiste Libé-Philippot
The human brain's increased cognitive abilities are underpinned by evolutionary adaptations at the molecular, cellular, and circuit levels of neural structures. This perspective explores how protracted neuronal development and divergent cel...