Angelina Lesnikova,Plinio Casarotto,Rafael Moliner et al.
Angelina Lesnikova et al.
Perineuronal nets (PNNs) have an important physiological role in the retention of learning by restricting cognitive flexibility. Their deposition peaks after developmental periods of intensive learning, usually in late childhood, and they h...
Plasticity of GluN1 at Ventral Hippocampal Synapses in the Infralimbic Cortex [0.03%]
ventral 海马在腹侧前额叶皮层中支配的突触的GluN1的可塑性
Yesenia Castillo-Ocampo,María Colón,Anixa Hernández et al.
Yesenia Castillo-Ocampo et al.
Although the infralimbic cortex (IL) is not thought to play a role in fear acquisition, recent experiments found evidence that synaptic plasticity is occurring at ventral hippocampal (vHPC) synapses in IL during auditory fear acquisition as...
Fear Memory Retrieval Is Associated With a Reduction in AMPA Receptor Density at Thalamic to Amygdala Intercalated Cell Synapses [0.03%]
恐惧记忆检索与丘脑至杏仁体嵌入细胞突触的AMPA受体密度降低相关
Anna Seewald,Sabine Schönherr,Heide Hörtnagl et al.
Anna Seewald et al.
The amygdala plays a crucial role in attaching emotional significance to environmental cues. Its intercalated cell masses (ITC) are tight clusters of GABAergic neurons, which are distributed around the basolateral amygdala complex. Distinct...
Reducing Auditory Nerve Excitability by Acute Antagonism of Ca2+-Permeable AMPA Receptors [0.03%]
通过急性拮抗钙渗透性AMPA受体降低听神经兴奋性
Amit Walia,Choongheon Lee,Jared Hartsock et al.
Amit Walia et al.
Hearing depends on glutamatergic synaptic transmission mediated by α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs). AMPARs are tetramers, where inclusion of the GluA2 subunit reduces overall channel conductance and ...
Fetal Neuroprotective Strategies: Therapeutic Agents and Their Underlying Synaptic Pathways [0.03%]
胎儿神经保护策略：治疗剂及其潜在的突触途径
Nada A Elsayed,Theresa M Boyer,Irina Burd
Nada A Elsayed
Synaptic signaling is integral for proper brain function. During fetal development, exposure to inflammation or mild hypoxic-ischemic insult may lead to synaptic changes and neurological damage that impairs future brain function. Preterm ne...
Effect of Unilateral Acoustic Trauma on Neuronal Firing Activity in the Inferior Colliculus of Mice [0.03%]
单侧噪声暴露对小鼠下丘神经元放电活动的影响
Chun-Jen Hsiao,Alexander V Galazyuk
Chun-Jen Hsiao
Neural hyperactivity induced by sound exposure often correlates with the development of hyperacusis and/or tinnitus. In laboratory animals, hyperactivity is typically induced by unilateral sound exposure to preserve one ear for further test...
Maturation of Heterogeneity in Afferent Synapse Ultrastructure in the Mouse Cochlea [0.03%]
小鼠耳蜗听觉传入突触超微结构异质性的成熟过程
Shelby A Payne,Matthew S Joens,Heather Chung et al.
Shelby A Payne et al.
Auditory nerve fibers (ANFs) innervating the same inner hair cell (IHC) may have identical frequency tuning but different sound response properties. In cat and guinea pig, ANF response properties correlate with afferent synapse morphology a...
Visualizing Synaptic Multi-Protein Patterns of Neuronal Tissue With DNA-Assisted Single-Molecule Localization Microscopy [0.03%]
基于DNA辅助的单分子定位显微镜技术可视化神经组织中的突触多蛋白模式
Kaarjel K Narayanasamy,Aleksandar Stojic,Yunqing Li et al.
Kaarjel K Narayanasamy et al.
The development of super-resolution microscopy (SRM) has widened our understanding of biomolecular structure and function in biological materials. Imaging multiple targets within a single area would elucidate their spatial localization rela...
Cannabinoid Modulation of Dopamine Release During Motivation, Periodic Reinforcement, Exploratory Behavior, Habit Formation, and Attention [0.03%]
大麻素在动机、周期性强化、探究行为、习惯形成和注意力下的多巴胺释放调制作用
Erik B Oleson,Lindsey R Hamilton,Devan M Gomez
Erik B Oleson
Motivational and attentional processes energize action sequences to facilitate evolutionary competition and promote behavioral fitness. Decades of neuropharmacology, electrophysiology and electrochemistry research indicate that the mesocort...
Striatal Synapse Degeneration and Dysfunction Are Reversed by Reactivation of Wnt Signaling [0.03%]
激活Wnt信号转导可逆转纹状体突触变性和功能障碍
Soledad Galli,Stefka H Stancheva,Tom Dufor et al.
Soledad Galli et al.
Synapse degeneration in the striatum has been associated with the early stages of Parkinson's and Huntington's diseases (PD and HD). However, the molecular mechanisms that trigger synaptic dysfunction and loss are not fully understood. Incr...