A spatial model of autophosphorylation of CaMKII predicts that the lifetime of phospho-CaMKII after induction of synaptic plasticity is greatly prolonged by CaM-trapping [0.03%]
一个对CaMKII自磷酸化的空间模型预测了由钙调素捕获所导致的突触可塑性引发后磷酰化CaMKII寿命大大延长的现象
Thomas M Bartol,Mariam Ordyan,Terrence J Sejnowski et al.
Thomas M Bartol et al.
Long-term potentiation (LTP) is a biochemical process that underlies learning in excitatory glutamatergic synapses in the Central Nervous System (CNS). A critical early driver of LTP is autophosphorylation of the abundant postsynaptic enzym...
Postsynaptic spiking determines anti-Hebbian LTD in visual cortex basket cells [0.03%]
突触后动作电位决定了视觉皮层篮细胞的反赫布长时程抑制
Christina Y C Chou,Wouter J Droogers,Txomin Lalanne et al.
Christina Y C Chou et al.
Long-term plasticity at pyramidal cell to basket cell (PC → BC) synapses is important for the functioning of cortical microcircuits. It is well known that at neocortical PC → PC synapses, dendritic calcium (Ca2+) dynamics signal coinciden...
β-adrenergic receptor-induced E-S potentiation in the dorsal and ventral hippocampus [0.03%]
背侧和腹侧海马区肾上腺素能受体诱导的E-S易化现象
George Trompoukis,Athina Miliou,Costas Papatheodoropoulos
George Trompoukis
β-adrenergic receptors (β-ARs) play a critical role in modulating learning, memory, emotionality, and long-term synaptic plasticity. Recent studies indicate that β-ARs are necessary for long-term potentiation (LTP) induction in the ventr...
Editorial: Role of protein palmitoylation in synaptic plasticity and neuronal differentiation, volume II [0.03%]
编辑部：蛋白质棕榈酰化在突触可塑性和神经元分化中的作用（第二卷）
Kevin P Koster,William N Green
Kevin P Koster
Amanda R McFarlan,Isabella Gomez,Christina Y C Chou et al.
Amanda R McFarlan et al.
Short-term plasticity is an important feature in the brain for shaping neural dynamics and for information processing. Short-term plasticity is known to depend on many factors including brain region, cortical layer, and cell type. Here we f...
Editorial: Regulation of AMPA receptors in brain diseases, from the genetic to the functional level, volume II [0.03%]
编辑部：脑疾病中AMPAR调节的遗传与功能机制（第二卷）
Laura Jiménez-Sánchez,Tak Pan Wong,Alberto Ouro
Laura Jiménez-Sánchez
Qi Wei Xu,Amanda Larosa,Tak Pan Wong
Qi Wei Xu
As a crucial player in excitatory synaptic transmission, AMPA receptors (AMPARs) contribute to the formation, regulation, and expression of social behaviors. AMPAR modifications have been associated with naturalistic social behaviors, such ...
Karri P Lamsa,Alfredo Kirkwood,P Jesper Sjöström
Karri P Lamsa
Friederike Steenken,Asli Pektaş,Christine Köppl
Friederike Steenken
Introduction: Age-related hearing difficulties have a complex etiology that includes degenerative processes in the sensory cochlea. The cochlea comprises the start of the afferent, ascending auditory pathway, but also rec...
Akap5 links synaptic dysfunction to neuroinflammatory signaling in a mouse model of infantile neuronal ceroid lipofuscinosis [0.03%]
Akap5将突触功能障碍与神经炎症信号联系起来以幼年型神经元 ceroid 淀粉样变病小鼠模型为例
Kevin P Koster,Zach Fyke,Thu T A Nguyen et al.
Kevin P Koster et al.
Palmitoylation and depalmitoylation represent dichotomic processes by which a labile posttranslational lipid modification regulates protein trafficking and degradation. The depalmitoylating enzyme, palmitoyl-protein thioesterase 1 (PPT1), i...