Dysfunctional brain connectivity and cognition in late preterm infants: novel perspectives on neurodevelopment and learning [0.03%]
早产儿大脑连接功能障碍与认知：神经发育和学习的新视角
María Inés Herrera
María Inés Herrera
Late preterm birth, occurred between 34 and 36 weeks of gestation, constitutes a risk factor for neurodevelopment. Despite being initially considered as a near term group of newborns, late preterm infants have shown dysfunctions in cerebral...
Tuning excitatory input to fast-spiking parvalbumin-positive interneurons: a lever for plasticity and hyperexcitability across the lifespan [0.03%]
调节快发放型_parvalbumin阳性中间神经元_的兴奋性输入：一生中突触可塑性和过度兴奋性的调控因素
Daniel Severin,Alfredo Kirkwood
Daniel Severin
Experience reshapes cortical circuits, yet plasticity is tightly gated-high during early critical periods and increasingly constrained with maturation. Later in life, aging and Alzheimer's disease (AD) create a growing demand to restrain ne...
Olof Lagerlöf,Qiongxuan Lu,Manish Bhattacharjee et al.
Olof Lagerlöf et al.
Anorexia nervosa (AN) is increasingly understood as a metabo-psychiatric disorder in which metabolic biology and neural circuit function are intrinsically intertwined. Genetic studies reveal that AN is associated with heritable metabolic tr...
Patterned pre-sensory spontaneous activity drives the structural refinement of developing cochlear ribbon synapses [0.03%]
条纹前感觉自发活动驱动发育性耳蜗 Ribbon 突触结构的精细调整
Victoria C Halim,Lukas Hallbrucker,Jan F Ahrend et al.
Victoria C Halim et al.
Introduction: In the mammalian cochlea, hearing relies on highly specialized ribbon-type synapses between sensory inner hair cells (IHCs) and postsynaptic spiral ganglion neurons. During early postnatal maturation, struct...
The Freiburg framework for multimodal ex situ assessment of neural plasticity in human cortical tissue [0.03%]
弗赖堡框架：体外多模态评估人类皮层组织神经可塑性的方法
Jakob Straehle,Christos Galanis,Lukas Grünewald et al.
Jakob Straehle et al.
Studying human cortical physiology requires access to viable brain tissue, yet species-specific differences limit the translational value of animal models. To address this, multiple laboratories have developed ex situ approaches for investi...
Rhythmic network activity in human brain slices: variability, mechanisms, and translational insights [0.03%]
人脑切片中的节律性网络活动：可变性、机制及转化研究的新见解
Danqing Yang,Dirk Feldmeyer
Danqing Yang
In vitro maintained human brain slices provide a unique experimental platform for investigating rhythmic neuronal network activity, bridging the gap between animal models and clinical studies. A wide range of spontaneous and induced oscilla...
Increased synaptic turnover in injured cortical axons: exploring the role of SARM1 ablation [0.03%]
损伤皮层轴突中突触周转增加：探讨SARM1缺失的作用
Ensieh Izadi,William Bennett,Jessica Collins et al.
Ensieh Izadi et al.
Introduction: Programmed axon degeneration significantly affects neural connectivity, however, the underlying mechanisms remain poorly understood, particularly in cortical regions. Sterile Alpha and TIR motif-containing p...
Enhanced information processing in the human neocortex: cellular mechanisms and translational perspectives [0.03%]
人新皮层的信息处理增强：细胞机制和转化视角
Manuela Tore,Laura Monni,Alessio Di Clemente et al.
Manuela Tore et al.
Understanding the sophisticated cognitive abilities of the human brain requires understanding its cellular and synaptic components. While rodent studies provide foundational knowledge, recent research using freshly resected human neocortica...
Group I metabotropic glutamate receptors differentially modulate excitatory transmission across interneuron types in the human cortex [0.03%]
人脑皮层中I组代谢型谷氨酸受体通过不同类型中间神经元差异化调节兴奋性传递
Joanna Grace Sandle,Gábor Molnár,Martin Tóth et al.
Joanna Grace Sandle et al.
Introduction: Group I metabotropic glutamate receptors (mGluRs) play a critical role in regulating neuronal excitability, synaptic strength, and cortical network activity. Although their physiological functions and involv...
Spatial characterization of backpropagating action potential-evoked Ca2+ signals in human cortical layer 2/3 pyramidal neurons [0.03%]
人类皮层2/3层锥体神经元中，传入动作电位诱发的钙信号的时空特征分析
Ildikó Szöts,Martin Tóth,Csongor Ludányi et al.
Ildikó Szöts et al.
Introduction: In pyramidal neurons, backpropagating action potentials (bAPs) activate voltage-gated calcium channels (VGCCs), producing compartment-specific dendritic Ca2+ transients. While extensively characterized in ro...