Neuron Type-Dependent Synaptic Activity in the Spinal Dorsal Horn of Opioid-Induced Hyperalgesia Mouse Model [0.03%]
依赖神经元类型的脊髓背角突触活动对阿片引起的异常疼痛的作用
Austin Kearns,Jazmine Jayasi,Xin Liu et al.
Austin Kearns et al.
Opioids are widely used for pain relief; however, chronic opioid use causes a paradoxical state of enhanced pain sensitivity, termed "Opioid-induced hyperalgesia (OIH)." Despite the clinical importance of OIH, the detailed mechanism by whic...
Synaptic Density and Neuronal Metabolic Function Measured by Positron Emission Tomography in the Unilateral 6-OHDA Rat Model of Parkinson's Disease [0.03%]
通过正电子发射断层扫描测定单侧6-羟基多巴胺大鼠模型的帕金森病突触密度和神经元代谢功能
Nakul Ravi Raval,Frederik Gudmundsen,Morten Juhl et al.
Nakul Ravi Raval et al.
Parkinson's disease (PD) is caused by progressive neurodegeneration and characterised by motor dysfunction. Neurodegeneration of dopaminergic neurons also causes aberrations within the cortico-striato-thalamo-cortical (CSTC) circuit, which ...
P Jesper Sjöström
P Jesper Sjöström
A Quantitative Perspective of Alpha-Synuclein Dynamics - Why Numbers Matter [0.03%]
α-突触核蛋白动力学的定量视角——为什么数量很重要
Christian G Specht
Christian G Specht
The function of synapses depends on spatially and temporally controlled molecular interactions between synaptic components that can be described in terms of copy numbers, binding affinities, and diffusion properties. To understand the funct...
The Non-receptor Tyrosine Kinase Pyk2 in Brain Function and Neurological and Psychiatric Diseases [0.03%]
非受体酪氨酸激酶Pyk2在大脑功能及神经和精神疾病中的作用
Benoit de Pins,Tiago Mendes,Albert Giralt et al.
Benoit de Pins et al.
Pyk2 is a non-receptor tyrosine kinase highly enriched in forebrain neurons. Pyk2 is closely related to focal adhesion kinase (FAK), which plays an important role in sensing cell contacts with extracellular matrix and other extracellular si...
Somatostatin Neurons in the Mouse Pontine Nucleus Activate GABAA Receptor Mediated Synaptic Currents in Locus Coeruleus Neurons [0.03%]
小鼠桥核Somatostatin神经元激活蓝斑神经元的GABAA受体介导的突触电流
Selena Garcia DuBar,Daniela Cosio,Holly Korthas et al.
Selena Garcia DuBar et al.
The pontine nuclei comprising the locus coeruleus (LC) and Barrington's nucleus (BRN) amongst others form the neural circuitry(s) that coordinates arousal and voiding behaviors. However, little is known about the synaptic connectivity of ne...
Age-Specific Modulation of Prefrontal Cortex LTP by Glucocorticoid Receptors Following Brief Exposure to HFD [0.03%]
短期高脂饮食后糖皮质激素受体对前额皮层LTP年龄特异性调节作用研究
Kuldeep Shrivastava,Tali Rosenberg,Noam Meiri et al.
Kuldeep Shrivastava et al.
The corticolimbic circuits in general and the medial prefrontal cortex in particular, undergo maturation during juvenility. It is thus expected that environmental challenges in forms of obesogenic diet can exert different effects in juvenil...
Luis E Boero,Shelby Payne,Maria Eugenia Gómez-Casati et al.
Luis E Boero et al.
Noise-induced hearing loss has gained relevance as one of the most common forms of hearing impairment. The anatomical correlates of hearing loss, principally cell damage and/or death, are relatively well-understood histologically. However, ...
Kimberly M Huber,Pierre Paoletti,P Jesper Sjöström
Kimberly M Huber
Parvalbumin Interneurons and Perineuronal Nets in the Hippocampus and Retrosplenial Cortex of Adult Male Mice After Early Social Isolation Stress and Perinatal NMDA Receptor Antagonist Treatment [0.03%]
早期社会隔离和围产期NMDA受体拮抗剂处理后成年雄性小鼠海马区及室旁皮层中的副室兴善神经元和周细胞网的变化
Patrycja Klimczak,Arianna Rizzo,Esther Castillo-Gómez et al.
Patrycja Klimczak et al.
Both early life aversive experiences and intrinsic alterations in early postnatal neurodevelopment are considered predisposing factors for psychiatric disorders, such as schizophrenia. The prefrontal cortex and the hippocampus have protract...