Dynamics of Neuromuscular Transmission Reproduced by Calcium-Dependent and Reversible Serial Transitions in the Vesicle Fusion Complex [0.03%]
由钙依赖和可逆的囊泡融合复合体转化产生的神经肌肉传递的动力学现象
Alejandro Martínez-Valencia,Guillermo Ramírez-Santiago,Francisco F De-Miguel
Alejandro Martínez-Valencia
Neuromuscular transmission, from spontaneous release to facilitation and depression, was accurately reproduced by a mechanistic kinetic model of sequential maturation transitions in the molecular fusion complex. The model incorporates three...
Selective Enrichment of Munc13-2 in Presynaptic Active Zones of Hippocampal Pyramidal Cells That Innervate mGluR1α Expressing Interneurons [0.03%]
富集突触前有效区的Munc13-2选择性地作用于海马锥体细胞并支配表达mGluR1α的中间神经元
Noemi Holderith,Mohammad Aldahabi,Zoltan Nusser
Noemi Holderith
Selective distribution of proteins in presynaptic active zones (AZs) is a prerequisite for generating postsynaptic target cell type-specific differences in presynaptic vesicle release probability (Pv) and short-term plasticity, a characteri...
Quantitative Imaging With DNA-PAINT for Applications in Synaptic Neuroscience [0.03%]
用于突触神经科学应用的DNA-PAINT定量成像技术
Eduard M Unterauer,Ralf Jungmann
Eduard M Unterauer
Super-resolution (SR) microscopy techniques have been advancing the understanding of neuronal protein networks and interactions. Unraveling the arrangement of proteins with molecular resolution provided novel insights into neuron cytoskelet...
Maria Royo,Beatriz Aznar Escolano,M Pilar Madrigal et al.
Maria Royo et al.
AMPA receptors (AMPARs) are critical for mediating glutamatergic synaptic transmission and plasticity, thus playing a major role in the molecular machinery underlying cellular substrates of memory and learning. Their expression pattern, tra...
Relevance of Cortical and Hippocampal Interneuron Functional Diversity to General Anesthetic Mechanisms: A Narrative Review [0.03%]
皮层和海马回抑制性中间神经元的功能多样性与全麻机制的相关性：综述文章
Iris A Speigel,Hugh C Hemmings Jr
Iris A Speigel
General anesthetics disrupt brain processes involved in consciousness by altering synaptic patterns of excitation and inhibition. In the cerebral cortex and hippocampus, GABAergic inhibition is largely mediated by inhibitory interneurons, a...
Blast-Induced Mild Traumatic Brain Injury Alterations of Corticotropin-Releasing Factor Neuronal Activity in the Mouse Hypothalamic Paraventricular Nucleus [0.03%]
爆炸引起的轻度创伤性脑损伤对小鼠下丘脑室旁核激素释放神经元活动的影响
Sarah Simmons,Ludovic D Langlois,Mario G Oyola et al.
Sarah Simmons et al.
Blast-induced mild traumatic brain injury (mbTBI) is the most common cause of TBI in US service members and veterans. Those exposed to TBI are at greater risk of developing neuropsychiatric disorders such as posttraumatic stress disorder, a...
Maria Teresa Romero-Barragán,Agnes Gruart,José M Delgado-García
Maria Teresa Romero-Barragán
Long-term potentiation (LTP) is an experimental procedure that shares certain mechanisms with neuronal learning and memory processes and represents a well-known example of synaptic plasticity. LTP consists of an increase of the synaptic res...
Towards a Comprehensive Optical Connectome at Single Synapse Resolution via Expansion Microscopy [0.03%]
基于扩张显微镜单突触分辨率的综合光学连接组学研究
Madison A Sneve,Kiryl D Piatkevich
Madison A Sneve
Mapping and determining the molecular identity of individual synapses is a crucial step towards the comprehensive reconstruction of neuronal circuits. Throughout the history of neuroscience, microscopy has been a key technology for mapping ...
Spindle-Shaped Neurons in the Human Posteromedial (Precuneus) Cortex [0.03%]
人类后内侧（precuneus）皮层中的纺锤形神经元
Francisco Javier Fuentealba-Villarroel,Josué Renner,Arlete Hilbig et al.
Francisco Javier Fuentealba-Villarroel et al.
The human posteromedial cortex (PMC), which includes the precuneus (PC), represents a multimodal brain area implicated in emotion, conscious awareness, spatial cognition, and social behavior. Here, we describe the presence of Nissl-stained ...
Hypothesis Relating the Structure, Biochemistry and Function of Active Zone Material Macromolecules at a Neuromuscular Junction [0.03%]
关于神经肌肉突触前主动区大分子结构、生化性质和功能的假说研究
Joseph A Szule
Joseph A Szule
This report integrates knowledge of in situ macromolecular structures and synaptic protein biochemistry to propose a unified hypothesis for the regulation of certain vesicle trafficking events (i.e., docking, priming, Ca2+-triggering, and m...