Thomas Edward Chater,Yukiko Goda
Thomas Edward Chater
Neurotransmission is critically dependent on the number, position, and composition of receptor proteins on the postsynaptic neuron. Of these, α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) are responsible for the ...
Activity-Dependent Modulation of Tonic GABA Currents by Endocannabinoids in Hirudo verbana [0.03%]
端到端GABA电流的活动依赖性调节由海 dragons verbana 内源大麻素介导
Riley T Paulsen,Brian D Burrell
Riley T Paulsen
Endocannabinoids are lipid neuromodulators that are synthesized on demand and primarily signal in a retrograde manner to elicit depression of excitatory and inhibitory synapses. Despite the considerable interest in their potential analgesic...
F Javier Rubio,Emmanuel Valjent,Bruce T Hope
F Javier Rubio
Eckart D Gundelfinger,Anna Karpova,Rainer Pielot et al.
Eckart D Gundelfinger et al.
Brain synapses pose special challenges on the quality control of their protein machineries as they are far away from the neuronal soma, display a high potential for plastic adaptation and have a high energy demand to fulfill their physiolog...
Five Hours Total Sleep Deprivation Does Not Affect CA1 Dendritic Length or Spine Density [0.03%]
五小时完全睡眠剥夺不影响海马CA1区树突长度及棘刺密度
Alvin T S Brodin,Sarolta Gabulya,Katrin Wellfelt et al.
Alvin T S Brodin et al.
Sleep is essential for long term memory function. However, the neuroanatomical consequences of sleep loss are disputed. Sleep deprivation has been reported to cause both decreases and increases of dendritic spine density. Here we use Thy1-G...
The Synaptic Extracellular Matrix: Long-Lived, Stable, and Still Remarkably Dynamic [0.03%]
突触细胞外基质：长寿、稳定且仍然充满活力
Tal M Dankovich,Silvio O Rizzoli
Tal M Dankovich
In the adult brain, synapses are tightly enwrapped by lattices of the extracellular matrix that consist of extremely long-lived molecules. These lattices are deemed to stabilize synapses, restrict the reorganization of their transmission ma...
Ling-Gang Wu,Chung Yu Chan
Ling-Gang Wu
Cytoskeletal filamentous actin (F-actin) has long been considered a molecule that may regulate exo- and endocytosis. However, its exact roles remained elusive. Recent studies shed new light on many crucial roles of F-actin in regulating exo...
Hearing Loss Increases Inhibitory Effects of Prefrontal Cortex Stimulation on Sound Evoked Activity in Medial Geniculate Nucleus [0.03%]
听觉剥夺增强前额叶皮层对丘脑室底核声音诱发神经活动的抑制作用
Chenae De Vis,Kristin M Barry,Wilhelmina H A M Mulders
Chenae De Vis
Sensory gating is the process whereby irrelevant sensory stimuli are inhibited on their way to higher cortical areas, allowing for focus on salient information. Sensory gating circuitry includes the thalamus as well as several cortical regi...
Synaptic Vesicle Recycling and the Endolysosomal System: A Reappraisal of Form and Function [0.03%]
论点：递质囊泡的回收与内溶酶体系统：形式和功能的再评价
Daniela Ivanova,Michael A Cousin
Daniela Ivanova
The endolysosomal system is present in all cell types. Within these cells, it performs a series of essential roles, such as trafficking and sorting of membrane cargo, intracellular signaling, control of metabolism and degradation. A specifi...
Correlative Live-Cell and Super-Resolution Imaging to Link Presynaptic Molecular Organisation With Function [0.03%]
相关活细胞和超分辨率成像技术建立突触前分子组织与功能的联系
Rachel E Jackson,Benjamin Compans,Juan Burrone
Rachel E Jackson
Information transfer at synapses occurs when vesicles fuse with the plasma membrane to release neurotransmitters, which then bind to receptors at the postsynaptic membrane. The process of neurotransmitter release varies dramatically between...