Resilient Hippocampal Gamma Rhythmogenesis and Parvalbumin-Expressing Interneuron Function Before and After Plaque Burden in 5xFAD Alzheimer's Disease Model [0.03%]
5×FAD阿尔茨海默病模型中小胶质细胞活化前后淀粉样斑块负荷水平下海马γ节律发生及Parvalbumin阳性中间神经元功能的稳健性
Connie A Mackenzie-Gray Scott,Kenneth A Pelkey,Adam P Caccavano et al.
Connie A Mackenzie-Gray Scott et al.
Recent studies have implicated impaired Parvalbumin Fast-Spiking Interneuron (PVIN) function as a precipitating factor underlying abnormalities in network synchrony, oscillatory rhythms, and cognition associated with Alzheimer's disease (AD...
Editorial: The Emerging Role of Endocannabinoids in Synaptic Plasticity, Reward, and Addiction [0.03%]
论点：内源性大麻素在突触可塑性、奖赏和成瘾中的作用不容忽视
Jeffrey G Edwards,Luigia Cristino,Dan P Covey
Jeffrey G Edwards
Selective Recruitment of Presynaptic and Postsynaptic Forms of mGluR-LTD [0.03%]
选择性招募突触前和突触后形式的mGluR-LTD
Thomas M Sanderson,Liam T Ralph,Mascia Amici et al.
Thomas M Sanderson et al.
In area CA1 of the hippocampus, long-term depression (LTD) can be induced by activating group I metabotropic glutamate receptors (mGluRs), with the selective agonist DHPG. There is evidence that mGluR-LTD can be expressed by either a decrea...
Cellular Strategies for Frequency-Dependent Computation of Interaural Time Difference [0.03%]
频率依赖的耳间时间差计算的细胞策略
Rei Yamada,Hiroshi Kuba
Rei Yamada
Binaural coincidence detection is the initial step in encoding interaural time differences (ITDs) for sound-source localization. In birds, neurons in the nucleus laminaris (NL) play a central role in this process. These neurons receive exci...
Identification of Synaptic DGKθ Interactors That Stimulate DGKθ Activity [0.03%]
DGKθ突触相互作用蛋白的鉴定促进DGKθ活性
Casey N Barber,Hana L Goldschmidt,Qianqian Ma et al.
Casey N Barber et al.
Lipids and their metabolic enzymes are a critical point of regulation for the membrane curvature required to induce membrane fusion during synaptic vesicle recycling. One such enzyme is diacylglycerol kinase θ (DGKθ), which produces phosp...
High-Resolution Fluorescence Imaging Combined With Computer Simulations to Quantitate Surface Dynamics and Nanoscale Organization of Neuroligin-1 at Synapses [0.03%]
结合高分辨率荧光成像和计算机模拟定量研究突触上神经联蛋白-1的表面动力学及纳米级组织状态
Matthieu Lagardère,Adèle Drouet,Matthieu Sainlos et al.
Matthieu Lagardère et al.
Neuroligins (NLGNs) form a family of cell adhesion molecules implicated in synapse development, but the mechanisms that retain these proteins at synapses are still incompletely understood. Recent studies indicate that surface-associated NLG...
Mechanisms Underlying Mu Opioid Receptor Effects on Parallel Fiber-Purkinje Cell Synaptic Transmission in Mouse Cerebellar Cortex [0.03%]
μ-阿片受体通过平行纤维-浦肯野细胞突触传递影响小鼠小脑皮质的机制研究
Yi Yang,Jin Bai,Jia-Yue Sun et al.
Yi Yang et al.
μ-opioid receptors (MOR) are widely expressed in the brain, varying in density in different areas. Activation of MORs underlies analgesia, euphoria, but may lead to tolerance, dependence, and ultimately opioid addiction. The Purkinje cell ...
Hansen Wang,Rita Balice-Gordon
Hansen Wang
Complementary Use of Super-Resolution Imaging Modalities to Study the Nanoscale Architecture of Inhibitory Synapses [0.03%]
利用超分辨率成像模态互补研究抑制性突触纳米结构
Sara E Gookin,Matthew R Taylor,Samantha L Schwartz et al.
Sara E Gookin et al.
The nanoscale architecture of synapses has been investigated using multiple super-resolution methods, revealing a common modular structure for scaffolds, neurotransmitter receptors, and presynaptic proteins. This fundamental organization of...
cAMP-Dependent Synaptic Plasticity at the Hippocampal Mossy Fiber Terminal [0.03%]
依赖于环磷酸腺苷的海马 mossy纤维终端的突触可塑性
Meishar Shahoha,Ronni Cohen,Yoav Ben-Simon et al.
Meishar Shahoha et al.
Cyclic adenosine monophosphate (cAMP) is a crucial second messenger involved in both pre- and postsynaptic plasticity in many neuronal types across species. In the hippocampal mossy fiber (MF) synapse, cAMP mediates presynaptic long-term po...