rTg(TauP301L)4510 mice exhibit increased VGlut1 in hippocampal presynaptic glutamatergic vesicles and increased extracellular glutamate release [0.03%]
Tau(P301L)小鼠海马区兴奋性突触前神经元中VGlut1增多及谷氨酸释放增加
Erika Taipala,Jeremiah C Pfitzer,Morgan Hellums et al.
Erika Taipala et al.
The molecular pathways that contribute to the onset of symptoms in tauopathy models, including Alzheimer's disease (AD), are difficult to distinguish because multiple changes can happen simultaneously at different stages of disease progress...
Healthy cardiac myocytes can decrease sympathetic hyperexcitability in the early stages of hypertension [0.03%]
健康的健康心肌细胞可以降低高血压早期的交感神经兴奋性
Harvey Davis,Kun Liu,Ni Li et al.
Harvey Davis et al.
Sympathetic neurons are powerful drivers of cardiac excitability. In the early stages of hypertension, sympathetic hyperactivity is underpinned by down regulation of M current and increased activity of Cav2.2 that is associated with greater...
Glucagon-like peptide 1 and glucose-dependent insulinotropic peptide hormones and novel receptor agonists protect synapses in Alzheimer's and Parkinson's diseases [0.03%]
胰高血糖素样肽1和葡萄糖依赖性促胰岛素多肽激素及新型受体激动剂可保护阿尔茨海默病和帕金森病的突触损伤
Christian Hölscher
Christian Hölscher
Glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) are peptide hormones and growth factors. A major pathological feature of both Alzheimer's dis-ease (AD) and Parkinson's disease (PD) is the loss of synaptic ...
Palmitoylation-regulated interactions of the pseudokinase calmodulin kinase-like vesicle-associated with membranes and Arc/Arg3.1 [0.03%]
棕榈酰化介导的伪激酶钙调素依赖型蛋白激酶样vesicle相关膜蛋白与Arc/Arg3.1相互作用调节机制
Barbara Barylko,Per Niklas Hedde,Clinton A Taylor et al.
Barbara Barylko et al.
Calmodulin kinase-like vesicle-associated (CaMKv), a pseudokinase belonging to the Ca2+/calmodulin-dependent kinase family, is expressed predominantly in brain and neural tissue. It may function in synaptic strengthening during spatial lear...
Unraveling Functional Diversity of Cortical Synaptic Architecture Through the Lens of Population Coding [0.03%]
从群体编码的角度解析皮层突触结构的功能多样性
Jacob L Yates,Benjamin Scholl
Jacob L Yates
The synaptic inputs to single cortical neurons exhibit substantial diversity in their sensory-driven activity. What this diversity reflects is unclear, and appears counter-productive in generating selective somatic responses to specific sti...
Editorial: Regulation of AMPA Receptors, From the Genetic to the Functional Level [0.03%]
编辑部文章：AMPA受体的调控——从遗传学到功能学水平
Alberto Ouro,Tak Pan Wong,Laura Jiménez-Sánchez
Alberto Ouro
Regulation of Inhibitory Signaling at the Receptor and Cellular Level; Advances in Our Understanding of GABAergic Neurotransmission and the Mechanisms by Which It Is Disrupted in Epilepsy [0.03%]
从受体水平到细胞水平的抑制性信号转导调节；关于GABA能神经传递的最新认识及其在癫痫中被破坏的机制
Allison E Tipton,Shelley J Russek
Allison E Tipton
Inhibitory signaling in the brain organizes the neural circuits that orchestrate how living creatures interact with the world around them and how they build representations of objects and ideas. Without tight control at multiple points of c...
Patch-to-Seq and Transcriptomic Analyses Yield Molecular Markers of Functionally Distinct Brainstem Serotonin Neurons [0.03%]
Patch-to-Seq和转录组分析揭示了功能不同的脑干血清素神经元的分子标志物
Gary C Mouradian Jr,Pengyuan Liu,Pablo Nakagawa et al.
Gary C Mouradian Jr et al.
Acute regulation of CO2 and pH homeostasis requires sensory feedback from peripheral (carotid body) and central (central) CO2/pH sensitive cells - so called respiratory chemoreceptors. Subsets of brainstem serotonin (5-HT) neurons in the me...
F Javier Rubio,Emmanuel Valjent,Bruce T Hope
F Javier Rubio
[This corrects the article DOI: 10.3389/fnsyn.2022.875904.]. Keywords: cellular engrams; drug of addiction; ...
Published Erratum
Frontiers in synaptic neuroscience. 2022 Jun 23:14:932503. DOI:10.3389/fnsyn.2022.932503 2022
Astrocyte: A Foe or a Friend in Intellectual Disability-Related Diseases [0.03%]
astrocyte：智力障碍相关疾病中的敌人还是朋友？
Busong Wang,Lu Zou,Min Li et al.
Busong Wang et al.
Intellectual disabilities are a type of neurodevelopmental disease caused by neurological dysfunction. Their incidence is largely associated with neural development. Astrocytes are the most widely distributed cells in the mammalian brain. P...