Christine M Gall,Aliza A Le,Gary Lynch
Christine M Gall
Activity-induced Long-Term Potentiation (LTP)-characterized as it is by rapid induction, synapse specificity, and remarkable persistence-has long been considered a primary substrate for memory encoding. There has however been considerable d...
High-frequency, high-intensity electrical stimulation selectively activates human fast-spiking interneurons [0.03%]
高频高强度电刺激可选择性激活人类快反应中间神经元
Jaeyoung Yoon,Ricardo Silva,Scellig Stone et al.
Jaeyoung Yoon et al.
Electrical brain stimulation has been used to treat epilepsy with therapeutic success, but without complete understanding of its cellular mechanisms of seizure suppression. Using acute human brain slices obtained from pharmaco-resistant epi...
Calcium at the crossroads of the immunometabolic signaling and comorbidity in schizophrenia [0.03%]
钙离子在免疫代谢信号传导和精神分裂症共病机制的交汇点上的作用
Milica M Borovcanin,Monojit Debnath,Slavica Minic Janicijevic et al.
Milica M Borovcanin et al.
Mechanistic insights into the synaptic damage-repair and regeneration processes in neurodegenerative Alzheimer's disease: phytochemicals as neuroprotective agents [0.03%]
神经退行性阿尔茨海默病中突触损伤-修复和再生过程的机制见解：植物化学物质作为神经保护剂的作用
Bharti Yadav,Prabhakar Gangwar,Kirti Kumari et al.
Bharti Yadav et al.
Synaptic failure is one of the earliest and most significant contributors to the cognitive decline in Alzheimer's disease (AD), preceding extensive neuronal loss. Although amyloid beta (Aβ) plaques and neurofibrillary tangles (NFTs) of tau...
NMDA receptors play an important role in postictal potentiation in immature rats [0.03%]
N-甲基-D天冬氨酸受体在幼年大鼠癫痫发作后强化中起重要作用
Pavel Mares,James L Burchfiel,Hana Kubova
Pavel Mares
Suicidality as a potential risk and therapeutic target during widespread GLP-1 receptor agonists use: implications of inflammation [0.03%]
在广泛使用GLP-1受体激动剂期间，自杀行为作为潜在风险和治疗目标及其炎症意义
Milica M Borovcanin,Ivica Petrovic
Milica M Borovcanin
NMDA receptor mediated tonic excitatory currents are elicited by EAAT inhibition on human neocortical pyramidal neurons [0.03%]
人新皮层锥体神经元中的兴奋性氨基丁酸能 tone 电流由海马氨基酸转运体抑制引发
Béla Márton,Levente Ecsedi,Krisztina Pocsai et al.
Béla Márton et al.
Introduction: Ambient glutamate is capable of regulating neural excitability and contributes to several brain pathologies. It is well established by experiments on rodent tissue that extrasynaptic glutamate -mainly regula...
Automated ROI detection allows rapid quantification of synaptic activity across tens of thousands of synapses in cell culture [0.03%]
自动ROI检测可在培养细胞中数千个突触内实现快速量化
John Carl Begley,Harald Prüss,Paul Turko et al.
John Carl Begley et al.
Synapses are the basic unit of information transfer between neurons. Their dysfunction is a common trigger of cognitive diseases and disorders. However, high-throughput analysis methods to assess synaptic function and dysfunction are lackin...
Synaptosomes isolated from cryopreserved MND motor cortex reveal altered calcium handling and reduced complex IV-linked respiration [0.03%]
来自冷冻保存的MND运动皮层的突触小体揭示了钙处理改变和复合物IV连接呼吸减少
Sean D Morrison,Lotten Ragnarsson,Sarah O Cook et al.
Sean D Morrison et al.
Motor neuron disease (MND) is marked by progressive neurodegeneration in which presynaptic Ca2+-handling and mitochondrial metabolism are thought to be vulnerable, but direct functional studies in human brain are scarce because most materia...
Experience-dependent critical period for synaptic plasticity in the rat olfactory amygdala [0.03%]
大鼠嗅球杏仁核中经验依赖的突触可塑性关键期
Belén Aburto-Ponce,Pedro Fernández-Aburto,Jorge Mpodozis et al.
Belén Aburto-Ponce et al.
Introduction: The amygdala is involved in processing and memory of emotional stimuli. The cortical regions of the amygdala are situated medially to the piriform cortex (PC) and are also considered part of the olfactory sy...