Calcium-independent phospholipase A2 beta is dispensable in inflammasome activation and its inhibition by bromoenol lactone [0.03%]
钙离子独立的磷脂酶A2β在炎性小体活化过程中可有可无且可被溴乙内酯抑制
Luigi Franchi,Grace Chen,Noemi Marina-Garcia et al.
Luigi Franchi et al.
Calcium-independent phospholipase A2 (iPLA2) has been suggested to play an important role in the activation of caspase-1 induced by lipopolysaccharides (LPS). Here, we used pharmacological and genetic approaches to study the role of iPLA 2 ...
Anthrax edema toxin inhibits Nox1-mediated formation of reactive oxygen species by colon epithelial cells [0.03%]
炭疽致水肿毒素通过抑制结肠上皮细胞中Nox1介导的活性氧形成而促进其存活
Jun-Sub Kim,Gary M Bokoch
Jun-Sub Kim
One major route of intoxication by Bacillus anthracis (anthrax) spores is via their ingestion and subsequent uptake by the intestinal epithelium. Anthrax edema toxin (ETx) is an adenylate cyclase that causes persistent elevation of cAMP in ...
The interleukin-1 receptor-associated kinase M selectively inhibits the alternative, instead of the classical NFkappaB pathway [0.03%]
一种选择性抑制另类NF-κB途径而不是经典NF-κB途径的白细胞介素1受体相关激酶M
Jianmin Su,Tongli Zhang,John Tyson et al.
Jianmin Su et al.
The innate immunity signaling process is controlled by numerous positive and negative regulators. The interleukin-1 receptor-associated kinase M (IRAK-M) is one of the negative regulators that contribute to the attenuation of NFkappaB activ...
Jan Potempa,Robert N Pike
Jan Potempa
The innate immune system of the human body has developed numerous mechanisms to control endogenous and exogenous bacteria and thus prevent infections by these microorganisms. These mechanisms range from physical barriers such as the skin or...
Ronald N Harty,Paula M Pitha,Atsushi Okumura
Ronald N Harty
The host innate immune response, including the production of type-I IFN, represents the primary line of defense against invading viral pathogens. Of the hundreds of IFN-stimulated genes (ISGs) discovered to date, ISG15 was one of the first ...
Tube Is an IRAK-4 homolog in a Toll pathway adapted for development and immunity [0.03%]
管腔是Toll信号通路中适应发育和免疫的IRAK-4同源物
Par Towb,Huaiyu Sun,Steven A Wasserman
Par Towb
Acting through the Pelle and IRAK family of protein kinases, Toll receptors mediate innate immune responses in animals ranging from insects to humans. In flies, the Toll pathway also functions in patterning of the syncytial embryo and requi...
Bacterial peptidoglycan degrading enzymes and their impact on host muropeptide detection [0.03%]
细菌肽聚糖降解酶及其对宿主MurNAc-P检测的影响
Jessica Humann,Laurel L Lenz
Jessica Humann
Peptidoglycan (PGN) is a major component of the bacterial cell envelope in both Gram-positive and Gram-negative bacteria. These muropeptides can be produced or modified by the activity of bacterial glycolytic and peptidolytic enzymes referr...
Background: The interactions between virus and the host immune response are nuanced and intricate. The cytokine response arguably plays a central role in dictating the outcome of virus infection, balancing inflammation an...