In cystic fibrosis homozygotes and heterozygotes, neutrophil apoptosis is delayed and modulated by diamide or roscovitine: evidence for an innate neutrophil disturbance [0.03%]
囊性纤维化患者的中性粒细胞凋亡速度减慢并受半胺基酸或罗斯考汀调控：中性粒细胞先天性紊乱的证据
Sandra Moriceau,Gérard Lenoir,Véronique Witko-Sarsat
Sandra Moriceau
Cystic fibrosis (CF) is a chronic inflammatory lung disease characterized by polymorphonuclear neutrophil (PMN)-dominated airway inflammation. Defective apoptosis might explain PMN persistence at these inflammation sites. We previously repo...
Macrophage response to apoptotic cells varies with the apoptotic trigger and is not altered by a deficiency in LRP expression [0.03%]
LRP表达缺陷不影响凋亡细胞的类型特异性识别和吞噬作用
Ana Kozmar,Mallary C Greenlee-Wacker,Suzanne S Bohlson
Ana Kozmar
Rapid engulfment of apoptotic cells in the absence of inflammation is required for maintenance of normal tissue homeostasis. The low-density lipoprotein receptor-related protein-1 (LRP/CD91) is a receptor mediating interactions between macr...
CD8- natural killer cells are greatly enriched in the human gastrointestinal tract and have the capacity to respond to bacteria [0.03%]
人肠道中存在丰富的CD8-NK细胞并能对细菌产生反应
Asa Lindgren,Cheol H Yun,Anna Lundgren et al.
Asa Lindgren et al.
Natural killer (NK) cells can be activated to produce IFN-gamma by lysate from Helicobacter pylori in combination with IL-12. Furthermore, NK cells in the gastrointestinal mucosa are likely to encounter H. pylori as well as other bacteria a...
Activity of lymphocyte subpopulations in polymicrobial sepsis and DHEA treatment in IL-6 knockout mice [0.03%]
IL-6基因敲除小鼠多微生物感染性脓毒症时淋巴细胞亚群的活性及DHEA的干预作用
Christian Zeckey,Frank Hildebrand,Petra Hoevel et al.
Christian Zeckey et al.
Introduction: Sepsis with subsequent multiorgan dysfunction remains the leading cause of mortality in trauma patients. A gender dimorphism in the host response after trauma and sepsis has been revealed. Dehydroepiandroste...
Novel adenovirus vectors 'capsid-displaying' a human complement inhibitor [0.03%]
一种新型腺病毒载体，在其衣壳上表达人体补体抑制剂
Sergey S Seregin,Zachary C Hartman,Daniel M Appledorn et al.
Sergey S Seregin et al.
Adenovirus (Ad) vectors are currently the most commonly utilized gene transfer vectors in humans worldwide. Unfortunately, upon contact with the circulatory system, Ads induce several, innate, complement-dependent toxicities that limit the ...
Neutrophil apoptosis: relevance to the innate immune response and inflammatory disease [0.03%]
中性粒细胞凋亡：与先天免疫反应和炎症疾病的相关性
Sarah Fox,Andrew E Leitch,Rodger Duffin et al.
Sarah Fox et al.
Neutrophils are the most abundant cell type involved in the innate immune response. They are rapidly recruited to sites of injury or infection where they engulf and kill invading microorganisms. Neutrophil apoptosis, the process of programm...
Amir S Yazdi,Greta Guarda,Marthe C D&#x;Ombrain et al.
Amir S Yazdi et al.
Caspases are best known for their role in apoptosis. More recently, they have gained prominence as critical mediators of innate immune responses. The so-called 'inflammatory caspases' include human caspase-1, -4, -5 and -12 and murine caspa...
Proteolytic inactivation of LL-37 by karilysin, a novel virulence mechanism of Tannerella forsythia [0.03%]
弗雷氏拟杆菌新型毒力因子卡里利辛通过蛋白酶降解LL-37发挥功能
Joanna Koziel,Aabdulkarim Y Karim,Kornelia Przybyszewska et al.
Joanna Koziel et al.
Tannerella forsythia is a gram-negative bacterium strongly associated with the development and/or progression of periodontal disease. Here, we have shown that a newly characterized matrix metalloprotease-like enzyme, referred to as karilysi...
Enhancement of antiviral activity of collectin trimers through cross-linking and mutagenesis of the carbohydrate recognition domain [0.03%]
通过交联和糖基识别区的点突变增强Collectin三聚体抗病毒活性
Mitchell R White,Patrick Boland,Tesfaldet Tecle et al.
Mitchell R White et al.
Surfactant protein D (SP-D) plays important roles in innate defense against respiratory viruses [including influenza A viruses (IAVs)]. Truncated trimers composed of its neck and carbohydrate recognition domains (NCRDs) bind various ligands...
Robin van Bruggen,Agata Drewniak,Anton T J Tool et al.
Robin van Bruggen et al.
Human neutrophils were found to express all known Toll-like receptors (TLRs) except TLR3 and TLR7. IRAK-4-deficient neutrophils were tested for their responsiveness to various TLR ligands. Essentially all TLR responses in neutrophils, inclu...