Toll-like receptor-9 expression is inversely correlated with estrogen receptor status in breast cancer [0.03%]
toll-like receptor-9在乳腺癌中的表达与雌激素受体状态负相关
Arja Jukkola-Vuorinen,Eeva Rahko,Katri S Vuopala et al.
Arja Jukkola-Vuorinen et al.
Toll-like receptor 9 (TLR9) recognizes microbial and vertebrate DNA. We previously demonstrated TLR9 expression in human breast cancer cell lines and showed that TLR9 ligands stimulate their in vitro invasion. The aim of this study was to c...
Single-stranded DNA oligoaptamers: molecular recognition and LPS antagonism are length- and secondary structure-dependent [0.03%]
单链DNA寡核糖核酸适配体：分子识别和LPS拮抗作用取决于长度和二级结构
J L Ding,S T Gan,B Ho
J L Ding
In Gram-negative bacterial infection, lipopolysaccharide (LPS) readily overwhelms the host innate immune system, which could result in inflammation and sepsis in severe cases. Therefore, developing anti-LPS molecules would confer an efficie...
Attenuated activation of macrophage TLR9 by DNA from virulent mycobacteria [0.03%]
毒力分支杆菌的DNA低激活巨噬细胞TLR9
Alexandra K Kiemer,Ryan H Senaratne,Jessica Hoppstädter et al.
Alexandra K Kiemer et al.
Alveolar macrophages are the first line of host defence against mycobacteria, but an insufficient host response allows survival of bacteria within macrophages. We aimed to investigate the role of Toll-like receptor 9 (TLR9) activation in ma...
Activation of TAFI on the surface of Streptococcus pyogenes evokes inflammatory reactions by modulating the kallikrein/kinin system [0.03%]
链球菌表面TAFI活化通过调节激肽/激肽素系统激发炎症反应
Sara H Bengtson,Caroline Sandén,Matthias Mörgelin et al.
Sara H Bengtson et al.
Bacteria-controlled regulation of host responses to infection is an important virulence mechanism that has been demonstrated to contribute to disease progression. Here we report that the human pathogen Streptococcus pyogenes employs the pro...
The role of epithelial integrin receptors in recognition of pulmonary pathogens [0.03%]
肺上皮整合素受体在肺部病原识别中的作用研究
Marina Ulanova,Sean Gravelle,Rebecca Barnes
Marina Ulanova
Integrins are a large family of heterodimeric transmembrane cell adhesion receptors. During the last decade, it has become clear that integrins significantly participate in various host-pathogen interactions involving pathogenic bacteria, f...
Cross-talk between human dendritic cell subsets influences expression of RNA sensors and inhibits picornavirus infection [0.03%]
人树突状细胞亚群之间的串扰影响RNA传感器的表达并抑制 Picornavirus 感染
Matthijs Kramer,Barbara M Schulte,Dagmar Eleveld-Trancikova et al.
Matthijs Kramer et al.
Dendritic cells (DCs) are professional antigen-presenting cells that provide a link between innate and adaptive immunity. Multiple DC subsets exist and their activation by microorganisms occurs through binding of conserved pathogen-derived ...
Natural killer T cells and atherosclerosis: form and function meet pathogenesis [0.03%]
自然杀伤T细胞和动脉粥样硬化：形态与功能遇见发病机制
Nicole A Braun,Roman Covarrubias,Amy S Major
Nicole A Braun
Atherosclerosis is a chronic inflammatory disease characterized by dyslipidemia and accumulation of lipids in the arterial intima, with activation of both innate and adaptive immunity. Reciprocally, dyslipidemia associated with atherosclero...
Dual role of heat shock proteins as regulators of apoptosis and innate immunity [0.03%]
热休克蛋白在凋亡和先天免疫中的双重调节作用
Anne-Laure Joly,Guillaume Wettstein,Gregoire Mignot et al.
Anne-Laure Joly et al.
Stress or heat shock proteins (HSPs) 70 and 90 are powerful chaperones whose expression is induced in response to a wide variety of physiological and environmental insults. These proteins have different functions depending on their intracel...
Monocytes and macrophages regulate immunity through dynamic networks of survival and cell death [0.03%]
单核细胞和巨噬细胞通过生存与细胞死亡的动态网络调节免疫反应
Arti Parihar,Timothy D Eubank,Andrea I Doseff
Arti Parihar
Monocytes and macrophages are central cells of the innate immune system, responsible for defending against diverse pathogens. While they originate from a common myeloid precursor and share functions in innate immunity, each has a very disti...
Véronique Witko-Sarsat
Véronique Witko-Sarsat