David Stanley,Jon Miller,Hasan Tunaz
David Stanley
Insects express 3 lines of protection from infections and invasions. Their cuticles and peritrophic membranes are physical barriers. Infections and invasions are quickly recognized within insect bodies, and recognition launches 2 lines of i...
The tinkerer at work [0.03%]
勤勉工作的修理工
Ulrich Theopold,David Schneider
Ulrich Theopold
The central kink region of fowlicidin-2, an alpha-helical host defense peptide, is critically involved in bacterial killing and endotoxin neutralization [0.03%]
蛙皮素-2中央扭结区在细菌杀伤和内毒素中和中的重要作用
Yanjing Xiao,Alvaro I Herrera,Yugendar R Bommineni et al.
Yanjing Xiao et al.
Fowlicidins are a group of newly identified chicken cathelicidin host defense peptides. We have shown that the putatively mature fowlicidin-2 of 31 amino acid residues possesses potent antibacterial and lipopolysaccharide (LPS)- neutralizin...
Host defence peptide LL-37 induces IL-6 expression in human bronchial epithelial cells by activation of the NF-kappaB signaling pathway [0.03%]
宿主防御多肽LL-37通过激活NF-κB信号途径诱导人支气管上皮细胞表达IL-6
Jelena Pistolic,Celine Cosseau,Yuexin Li et al.
Jelena Pistolic et al.
LL-37, the only member of the cathelicidin family of cationic host defence peptides in humans, has been shown to mediate multiple immunomodulatory effects and as such is thought to be an important component of innate immune responses. A gro...
Actin and phosphoinositide recruitment to fully formed Candida albicans phagosomes in mouse macrophages [0.03%]
白色念珠菌感染的小鼠巨噬细胞中肌动蛋白和磷脂底物募集到成熟的吞噬体中
Sigrid E M Heinsbroek,Lynn A Kamen,Philip R Taylor et al.
Sigrid E M Heinsbroek et al.
Candida albicans is a dimorphic yeast that enters macrophages (Mphi) via the beta-glucan receptor dectin-1. Phagocytosis of C. albicans is characterized by actin polymerization, Syk kinase activation and rapid acquisition of phagolysosomal ...
Non-opsonic recognition of Mycobacterium tuberculosis by phagocytes [0.03%]
非 opsonic 结合的巨噬细胞对结核杆菌的作用
Georgia Schäfer,Muazzam Jacobs,Robert J Wilkinson et al.
Georgia Schäfer et al.
The interactions between Mycobacterium tuberculosis and host phagocytes such as macrophages and dendritic cells are central to both immunity and pathogenesis. Many receptors have been implicated in recognition and binding of M. tuberculosis...
Sonja Oehmcke,Matthias Mörgelin,Heiko Herwald
Sonja Oehmcke
Pattern recognition is an integral part of the innate immune system. The human contact system has been shown to interact with the surface of many bacterial and fungal pathogens, and once activated leads to the generation of antimicrobial pe...
Survival of bacterial biofilms within neutrophil extracellular traps promotes nontypeable Haemophilus influenzae persistence in the chinchilla model for otitis media [0.03%]
细菌生物膜在中性粒细胞胞外陷阱内的存活可促进流感嗜血杆菌在仓鼠急性中耳炎模型中的持久存在
Wenzhou Hong,Richard A Juneau,Bing Pang et al.
Wenzhou Hong et al.
Nontypeable Haemophilus influenzae (NTHi) is a leading cause of acute and chronic otitis media, which are a major public health problem worldwide. The persistence of NTHi during chronic and recurrent otitis media infections involves multice...
M1 protein allows Group A streptococcal survival in phagocyte extracellular traps through cathelicidin inhibition [0.03%]
M1蛋白通过抑制宿主 CathB 来促进化脓链球菌在胞外陷阱网络中的存活
Xavier Lauth,Maren von Köckritz-Blickwede,Case W McNamara et al.
Xavier Lauth et al.
M1 protein contributes to Group A Streptococcus (GAS) systemic virulence by interfering with phagocytosis and through proinflammatory activities when released from the cell surface. Here we identify a novel role of M1 protein in the stimula...
Indira Neeli,Nishant Dwivedi,Salar Khan et al.
Indira Neeli et al.
Neutrophils use intricate mechanisms for capturing and killing invading microorganisms. One mechanism entails the release of relaxed chromatin from the cell. Microbes are trapped by the extracellular chromatin and exposed to high local conc...