Vero cells as a model to study the effects of adenoviral gene delivery vectors on the RNAi system in context of viral infection [0.03%]
有关腺病毒载体基因传递对病毒感染背景下RNA干扰系统影响的vero细胞模型研究
Alexey A Matskevich,Jiun-Shan Jung,Michael Schümann et al.
Alexey A Matskevich et al.
Technology based on RNA interference (RNAi) is a promising source for new antiviral therapies. Although the application of RNAi has been studied extensively, significant problems with using RNAi remain. Very few studies have specifically as...
TRIF, and TRIF-interacting TLRs differentially modulate several adenovirus vector-induced immune responses [0.03%]
TRIF及其相互作用的TLR不同地调节多种腺病毒载体诱导的免疫应答
D M Appledorn,S Patial,S Godbehere et al.
D M Appledorn et al.
The use of Adenovirus (Ad)-based vectors has proven to be a useful platform for the development of gene therapy and vaccine protocols. The immunological mechanisms underlying these properties need to be identified and understood to foster s...
Mark C Dessing,Koenraad F van der Sluijs,C Arnold Spek et al.
Mark C Dessing et al.
Background: Many in vitro studies have focused on gene expression in influenza-infected leukocytes, lung tissue or cell lines. However, knowledge of in vivo gene expression in these compartments is limited. ...
Blockade of LOX-1 prevents endotoxin-induced acute lung inflammation and injury in mice [0.03%]
阻断LOX-1可防止内毒素所致小鼠急性肺炎症和损伤
Ping Zhang,Ming-Cheh Liu,Lili Cheng et al.
Ping Zhang et al.
Lectin-like oxidized low-density lipoprotein (LDL) receptor-1 (LOX-1), a cell surface receptor expressed in endothelial cells, is known to mediate oxidized LDL-induced vascular inflammation and atherogenesis. Although the role of LOX-1 in v...
Genetic variation in Toll-like receptor signalling and the risk of inflammatory and immune diseases [0.03%]
toll样受体信号转导的遗传多态性与炎症和免疫性疾病的关系研究
Sinead C Corr,Luke A J O&#x;Neill
Sinead C Corr
There has been growing interest in the role of host genetic factors in humans and susceptibility to infectious and inflammatory diseases. Genetic variation in Toll-like receptors (TLRs), key innate immune receptors or their signalling molec...
Clett Erridge
Clett Erridge
Atherosclerosis is a chronic inflammatory disease of the arteries that is characterised by the activation of endothelial cells, the recruitment of monocytes into the vessel wall and the differentiation of recruited macrophages into choleste...
The c-src homologue Src64B is sufficient to activate the Drosophila cellular immune response [0.03%]
Src64B蛋白激酶足以激活果蝇的免疫反应
Michael J Williams
Michael J Williams
The Drosophila larval cellular immune response involves cells (haemocytes) that can be recruited from a haematopoietic organ known as the lymph gland, as well as a sessile population of cells found just underneath the larval cuticle arrange...
Genetic ablation of Drosophila phagocytes reveals their contribution to both development and resistance to bacterial infection [0.03%]
果蝇遗传性噬菌体细胞的消融使其在发育和抵抗细菌感染中的贡献被揭示出来
Arnaud Defaye,Iwan Evans,Michèle Crozatier et al.
Arnaud Defaye et al.
Drosophila phagocytes participate in development and immune responses through their abilities to perform phagocytosis and/or secrete extra-cellular matrix components, antimicrobial peptides, clotting factors and signalling molecules. Howeve...
Activation of insect phenoloxidase after injury: endogenous versus foreign elicitors [0.03%]
损伤后昆虫苯醇氧化酶的激活：内源性与外源性活化剂的区别
Gawa Bidla,Thomas Hauling,Mitchell S Dushay et al.
Gawa Bidla et al.
The enzyme phenoloxidase (PO) is one of the first immune molecules that was identified in invertebrates. Recently, the immune function of PO has been challenged. We tested how PO is activated following injury in 2 insects, i.e. the fruit fl...
Evolution and function of innate immune receptors--insights from marine invertebrates [0.03%]
固有免疫受体的进化和功能——来自海洋无脊椎动物的启示
Philip Rosenstiel,Eva E R Philipp,Stefan Schreiber et al.
Philip Rosenstiel et al.
Innate, nonadaptive immune receptors represent phylogenetically ancient first-line sensors of invariant non-self patterns and other cellular danger signals. From lower animal phyla to vertebrates, most pathogens are immediately detected by ...