TLR9-Dependent Activation by Inactivated Parapoxvirus Ovis in Murine Bone Marrow-Derived Dendritic Cells Is Associated with Specific Strain-Dependent Dendritic Cell Subsets [0.03%]
灭活的山羊传染性脓疱病毒诱导骨髓来源树突状细胞TLR9依赖性的激活与特定菌株相关的树突状细胞亚群有关
Yanqin Du,Hang Sun,Sonakshi Bhattacharjee et al.
Yanqin Du et al.
Introduction: Inactivated parapoxvirus ovis (iPPVO) exerts strong immunomodulatory effects on innate immune cells, making it an attractive therapeutic candidate. However, little is known about the signaling pathways that ...
Unraveling the Intricate Web: Complement Activation Shapes the Pathogenesis of Sepsis-Induced Coagulopathy [0.03%]
剥茧抽丝：补体激活与脓毒症凝血病发病机制的关系研究
Xin Wei,Ye Tu,Shuhong Bu et al.
Xin Wei et al.
Background: Sepsis-associated coagulopathy specifically refers to widespread systemic coagulation activation accompanied by a high risk of hemorrhage and organ damage, which in severe cases manifests as disseminated intra...
The Inflammatory Response Induced by Aspergillus fumigatus Conidia Is Dependent on Complement Activation: Insight from a Whole Blood Model [0.03%]
烟色曲霉芽孢诱导的炎症反应依赖补体活化：来自全血模型的新见解
Beatrice Fageräng,Maximilian Peter Götz,Leon Cyranka et al.
Beatrice Fageräng et al.
Introduction: We aimed to elucidate the inflammatory response of Aspergillus fumigatus conidia in a whole-blood model of innate immune activation and to compare it with the well-characterized inflammatory reaction to Esch...
Murine Ribonuclease 6 Limits Bacterial Dissemination during Experimental Urinary Tract Infection [0.03%]
小鼠核糖核酸酶6在实验性泌尿系统感染过程中限制细菌扩散
Hanna Cortado,Macie Kercsmar,Birong Li et al.
Hanna Cortado et al.
Introduction: The ribonuclease (RNase) A superfamily encodes cationic antimicrobial proteins with potent microbicidal activity toward uropathogenic bacteria. Ribonuclease 6 (RNase6) is an evolutionarily conserved, leukocy...
Pattern-Recognition Receptors and Immunometabolic Reprogramming: What We Know and What to Explore [0.03%]
模式识别受体与免疫代谢重编程：已知和待探究的事宜
Vijay Kumar,John H Stewart Iv
Vijay Kumar
Background: Evolutionarily, immune response is a complex mechanism that protects the host from internal and external threats. Pattern-recognition receptors (PRRs) recognize MAMPs, PAMPs, and DAMPs to initiate a protective...
Stat3 Regulates Developmental Hematopoiesis and Impacts Myeloid Cell Function via Canonical and Non-Canonical Modalities [0.03%]
Stat3通过经典和非经典途径调节发育期造血作用并影响髓系细胞功能
Mohamed Luban Sobah,Clifford Liongue,Alister C Ward
Mohamed Luban Sobah
Introduction: Signal transducer and activator of transcription (STAT) 3 is extensively involved in the development, homeostasis, and function of immune cells, with STAT3 disruption associated with human immune-related dis...
Hydrogen peroxide is responsible for the cytotoxic effects of Streptococcus pneumoniae on primary microglia in the absence of pneumolysin [0.03%]
无肺炎球菌溶素情况下过氧化氢导致肺炎链球菌对原代小胶质细胞的细胞毒性作用
Franziska Jennert,Désirée Schaaf,Roland Nau et al.
Franziska Jennert et al.
Introduction: Streptococcus pneumoniae is the most common cause of bacterial meningitis and meningoencephalitis in humans. The bacterium produces numerous virulence determinants, among them hydrogen peroxide (H2O2) and pn...
Type I Interferon, Induced by Adenovirus or Adenoviral Vector Infection, Regulates the Cytokine Response to Lipopolysaccharide in a Macrophage Type-Specific Manner [0.03%]
I型干扰素通过腺病毒或腺病毒载体感染诱导，以巨噬细胞类型特异性方式调节对脂多糖的细胞因子反应
Mareike D Maler,Sophie Zwick,Carsten Kallfass et al.
Mareike D Maler et al.
Introduction: While TLR ligands derived from microbial flora and pathogens are important activators of the innate immune system, a variety of factors such as intracellular bacteria, viruses, and parasites can induce a sta...
Human Host Defense Peptide LL-37 Suppresses TNFα-Mediated Matrix Metalloproteinases MMP9 and MMP13 in Human Bronchial Epithelial Cells [0.03%]
人源防御肽LL-37抑制TNFα介导的人支气管上皮细胞基质金属蛋白酶MMP9和MMP13的表达
Anthony Altieri,Courtney Lynn Marshall,Padmanie Ramotar et al.
Anthony Altieri et al.
Introduction: TNFα-inducible matrix metalloproteinases play a critical role in the process of airway remodeling in respiratory inflammatory disease including asthma. The cationic host defense peptide LL-37 is elevated in...
TLRs1-10 Protein Expression in Circulating Human White Blood Cells during Bacterial and COVID-19 Infections [0.03%]
细菌和COVID-19感染期间循环人白细胞中TLR1-10蛋白的表达
Louise Chomel,Mathieu Vogt,Julien Demiselle et al.
Louise Chomel et al.
Introduction: Toll-like receptors play crucial roles in the sepsis-induced systemic inflammatory response. Septic shock mortality correlates with overexpression of neutrophilic TLR2 and TLR9, while the role of TLR4 overex...