ClpX contributes to innate defense peptide resistance and virulence phenotypes of Bacillus anthracis [0.03%]
ClpX参与了芽孢杆菌的固有防御肽抗性和毒力表型
Shauna M McGillivray,Celia M Ebrahimi,Nathan Fisher et al.
Shauna M McGillivray et al.
Bacillus anthracis is a National Institute of Allergy and Infectious Diseases Category A priority pathogen and the causative agent of the deadly disease anthrax. We applied a transposon mutagenesis system to screen for novel chromosomally e...
Toll-like receptor 2-independent and MyD88-dependent gene expression in the mouse brain [0.03%]
小鼠脑内独立于 Toll 样受体 2 而依赖髓样细胞分化 primary response gene 88 的基因表达
Gaëlle Naert,Nathalie Laflamme,Serge Rivest
Gaëlle Naert
Toll-like receptors (TLRs) are essential to mount a rapid innate immune reaction to pathogens. Although TLR2 is the key receptor for pathogen-associated molecular patterns from Gram-positive bacteria, a robust transcriptional activation of ...
A novel serine protease inhibitor acts as an immunomodulatory switch while maintaining homeostasis [0.03%]
一种新型丝氨酸蛋白酶抑制剂在维持稳态的同时充当免疫调节开关
N Jiang,S Thangamani,C F Chor et al.
N Jiang et al.
Serine protease cascades boost immune responses while maintaining homeostasis. These crucial actions are intricately regulated by cognate serine protease inhibitors. However, the mechanism underlying such a dynamic immunomodulation during a...
Ironing out the wrinkles in host defense: interactions between iron homeostasis and innate immunity [0.03%]
化解宿主防御中的难题：铁稳态与先天免疫间的相互作用
Lijian Wang,Bobby J Cherayil
Lijian Wang
Iron is an essential micronutrient for both microbial pathogens and their mammalian hosts. Changes in iron availability and distribution have significant effects on pathogen virulence and on the immune response to infection. Recent advances...
Toll-like receptor 2 senses hepatitis C virus core protein but not infectious viral particles [0.03%]
toll-like receptor 2可以识别HCV核心蛋白但不能识别感染性的病毒颗粒
Marco Hoffmann,Mirjam B Zeisel,Nikolaus Jilg et al.
Marco Hoffmann et al.
Toll-like receptors (TLRs) are pathogen recognition molecules activating the innate immune system. Cell surface expressed TLRs, such as TLR2 and TLR4, have been shown to play an important role in human host defenses against viruses through ...
Measure and countermeasure: type I IFN (IFN-alpha/beta) antiviral response against West Nile virus [0.03%]
攻与防：I型干扰素（IFN-α/β）抵抗西尼罗病毒的抗病毒反应
Stephane Daffis,Mehul S Suthar,Michael Gale Jr et al.
Stephane Daffis et al.
As a first line of defense after viral infection, host cells develop an intrinsic immune response to control virus dissemination and protect against serious infection. Recent experiments have shown a dominant role of the IFN-alpha/beta resp...
The innate immune response: an important partner in shaping coxsackievirus-mediated autoimmunity [0.03%]
固有免疫反应在柯萨奇病毒介导的自身免疫中的重要作用
Martin J Richer,Marc S Horwitz
Martin J Richer
To protect against viral infection, the immune response is critically dependent on innate sensing mechanisms to provide rapid detection of pathogens and allow for the development of an appropriate adaptive immune response. Mounting evidence...
Jian Ding,Yi-Ying Chou,Theresa L Chang
Jian Ding
Defensins are antimicrobial peptides important to innate host defense. In addition to their direct antimicrobial effect, defensins modulate immune responses. Increasing evidence indicates that defensins exhibit complex functions by positive...
Modulation of cellular tropism and innate antiviral response by viral glycans [0.03%]
病毒糖基对细胞嗜性及固有抗病毒反应的调控作用
Kristin M Rogers,Mark Heise
Kristin M Rogers
Arthropod-borne viruses (arboviruses) are a significant cause of human and animal disease worldwide. Multiple interactions between virus and the host innate immune system ultimately determine the pathogenesis and clinical outcome of the inf...
Carol Shoshkes Reiss
Carol Shoshkes Reiss