Eosinophils utilize multiple chemokine receptors for chemotaxis to the parasitic nematode Strongyloides stercoralis [0.03%]
嗜酸性粒细胞利用多种化学趋化因子受体向寄生线虫斯特洛奇奥伊德斯 Stercoralis 化学趋向性运输
Louis H Stein,Kevin M Redding,James J Lee et al.
Louis H Stein et al.
Protective innate immunity to the nematode Strongyloides stercoralis requires eosinophils in the parasite killing process. Experiments were performed to determine if an extract of S. stercoralis would trigger eosinophil chemotaxis, and to t...
Direct cleavage, proteasomal degradation and sequestration: three mechanisms of viral subversion of type I interferon responses [0.03%]
直接切割、蛋白酶体降解和隔离：病毒规避I型干扰素反应的三种机制
Gerald M McInerney,Gunilla B Karlsson Hedestam
Gerald M McInerney
The host type I interferon (IFN) system is central in antiviral defence and represents one of the greatest obstacles for a virus to overcome in order to establish a productive infection. Viruses have evolved many different mechanisms to rep...
Divergent effects on phagocytosis by macrophage-derived oxygen radicals [0.03%]
巨噬细胞源性氧自由基对吞噬作用的发散效应
Kelly L Brown,Karin Christenson,Anna Karlsson et al.
Kelly L Brown et al.
Clearance of senescent cells from damaged tissue is a crucial step to successfully resolve an inflammatory response. Poor clearance has been attributed to defects in neutrophil apoptosis, a process that is regulated in part by reactive oxyg...
Signaling pathways of the TREM-1- and TLR4-mediated neutrophil oxidative burst [0.03%]
TREM-1和TLR4介导的中性粒细胞氧化爆发信号通路研究进展
Philipp Haselmayer,Martin Daniel,Christine Tertilt et al.
Philipp Haselmayer et al.
The triggering receptor expressed on myeloid cells 1 (TREM-1) is involved in the innate inflammatory response to microbial infections. Activation and expression of TREM-1 by polymorphonuclear neutrophils (PMN) occurs in concert with Toll-li...
NOX4 expression in human microglia leads to constitutive generation of reactive oxygen species and to constitutive IL-6 expression [0.03%]
人巨噬细胞中NOX4的表达导致活性氧的生成及白介素六的表达
Bin Li,Karen Bedard,Silvia Sorce et al.
Bin Li et al.
Reactive oxygen species (ROS) generation by microglia is implicated in neuroinflammation and neurotoxicity, as well as in host defense, cell proliferation and excitatory amino acid release. Recent studies demonstrate that primary microglia ...
New p22-phox monoclonal antibodies: identification of a conformational probe for cytochrome b 558 [0.03%]
新的p22-phox单克隆抗体：细胞色素b 558的构象探针的鉴定
Yannick Campion,Algirdas J Jesaitis,Minh Vu Chuong Nguyen et al.
Yannick Campion et al.
The phagocyte NADPH oxidase, belonging to the NADPH oxidase family (Nox), is dedicated to the production of bactericidal reactive oxygen species. The enzyme catalytic center is the cytochrome b(558), formed by 2 subunits, Nox2 (gp91-phox) a...
The domain organization of p67 phox, a protein required for activation of the superoxide-producing NADPH oxidase in phagocytes [0.03%]
参与吞噬细胞中超氧阴离子生成酶NADPH氧化酶激活的蛋白质p67phox的结构域组织形式研究
Satoru Yuzawa,Kei Miyano,Kazuya Honbou et al.
Satoru Yuzawa et al.
The phagocyte NADPH oxidase, crucial for innate immunity, is dormant in resting cells, but becomes activated during phagocytosis to produce superoxide, a precursor of microbicidal oxidants. In activation of the oxidase, the multidomain prot...
DNase I inhibits a late phase of reactive oxygen species production in neutrophils [0.03%]
DNA酶I抑制中性粒细胞中的一种晚期活性氧产生阶段
Daniela B Munafo,Jennifer L Johnson,Agnieszka A Brzezinska et al.
Daniela B Munafo et al.
Neutrophils kill bacteria on extracellular complexes of DNA fibers and bactericidal proteins known as neutrophil extracellular traps (NETs). The NET composition and the bactericidal mechanisms they use are not fully understood. Here, we sho...
Role of NADPH oxidase in formation and function of multinucleated giant cells [0.03%]
NADPH氧化酶在多核巨细胞形成和功能中的作用
Mark T Quinn,Igor A Schepetkin
Mark T Quinn
Macrophages play essential roles in a wide variety of physiological and pathological processes. One of the unique features of these phagocytic leukocytes is their ability to fuse, forming multinucleated giant cells. Multinucleated giant cel...
Gary M Bokoch
Gary M Bokoch