Protective role of complement C5a in an experimental model of Staphylococcus aureus bacteremia [0.03%]
补体C5a在金黄色葡萄球菌菌血症小鼠模型中的保护作用
Maren von Köckritz-Blickwede,Stephanie Konrad,Simon Foster et al.
Maren von Köckritz-Blickwede et al.
The complement system is a key component of the innate immune response. Here, we have examined the role of complement anaphylatoxin C5a in an experimental model of Staphylococcus aureus bacteremia. Our data provide compelling evidence for a...
Phosphatidylinositol 3-kinase regulates macrophage responses to double-stranded RNA and encephalomyocarditis virus [0.03%]
磷脂酰肌醇3激酶调节多聚鸟苷酸和エンセファロミヨカードィタス病毒感染诱导的巨噬细胞反应
Wieke Freudenburg,Jason M Moran,Nathan H Lents et al.
Wieke Freudenburg et al.
Virus infection of macrophages stimulates the expression of proinflammatory and antiviral genes interleukin-1 (IL-1), inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). In this study, we show that phosphatidylinositol 3-ki...
Precursor processing of human defensin-5 is essential to the multiple functions in vitro and in vivo [0.03%]
人定α-防御素5的前体加工对其体内外功能至关重要
Chisato Ishikawa,Hiroki Tanabe,Atsuo Maemoto et al.
Chisato Ishikawa et al.
Human defensin-5 (HD-5) is one of the major antimicrobial peptides secreted by Paneth cells in the human small intestine. HD-5 is produced and stored as a propeptide in Paneth cell granules, secreted in response to stimulation by cholinergi...
Cory M Robinson,Dawn O&#x;Dee,Travis Hamilton et al.
Cory M Robinson et al.
Interferon (IFN)-gamma is important to the immune defense against intracellular pathogens and specifically the ability of macrophages to control Mycobacterium tuberculosis (MTB). Increasing evidence has accumulated to support the idea that ...
A PTP4A3 peptide PIMAP39 modulates TNF-alpha levels and endotoxic shock [0.03%]
PTP4A3肽PIMAP39可调节TNF-α水平及内毒素性休克作用
Xiaoren Tang,Timothy Woodward,Salomon Amar
Xiaoren Tang
Lipopolysaccharide (LPS) stimulation of macrophages initiates intracellular signaling pathways leading to activation of MAPK and its subsequent influence on cytokine production. We recently identified a LITAF-STAT6(B) complex regulated by p...
Interactions of ficolin and mannose-binding lectin with fibrinogen/fibrin augment the lectin complement pathway [0.03%]
补体lect2途径识别活化因子ix上的c3b和c4b
Yuichi Endo,Naomi Nakazawa,Daisuke Iwaki et al.
Yuichi Endo et al.
Ficolin and mannose-binding lectin (MBL) are animal lectins that are involved in innate immunity by initiating the lectin complement pathway. Here, we report that interactions between these lectins and fibrinogen/fibrin augment the lectin p...
Misao Matsushita
Misao Matsushita
Ficolins are a group of oligomeric lectins with subunits consisting of both collagen-like and fibrinogen-like domains. The majority of ficolins identified in vertebrates and invertebrates to date recognize N-acetylglucosamine (GlcNAc). X-ra...
Virginie Garlatti,Lydie Martin,Monique Lacroix et al.
Virginie Garlatti et al.
Innate immunity relies upon the ability of a variety of recognition molecules to sense pathogens through conserved molecular signatures that are often carbohydrates. Ficolins are oligomeric proteins assembled from collagen-like stalks and f...
The genetics of ficolins [0.03%]
Fc蛋白的遗传学
Peter Garred,Christian Honoré,Ying Jie Ma et al.
Peter Garred et al.
Ficolins constitute a family of proteins whose biological role has been an enigma for many years. Over the past few years it has become evident that ficolins are part of the innate immune system and function as recognition molecules in the ...
The ficolins [0.03%]
糖基结合凝集素FCN家族成员
Peter Garred,Niels Borregaard
Peter Garred