Marc A Williams
Marc A Williams
Expression of the inhibitory CD200 receptor is associated with alternative macrophage activation [0.03%]
抑制性CD200受体的表达与另类小胶质细胞活化相关
Nathalie Koning,Marco van Eijk,Walter Pouwels et al.
Nathalie Koning et al.
Classical macrophage activation is inhibited by the CD200 receptor (CD200R). Here, we show that CD200R expression was specifically induced on human in vitro polarized macrophages of the alternatively activated M2a subtype, generated by incu...
A large-scale RNAi screen identifies Deaf1 as a regulator of innate immune responses in Drosophila [0.03%]
大规模RNA干扰筛选鉴定出Deaf1是调控果蝇先天免疫反应的因子
David Kuttenkeuler,Nadège Pelte,Anan Ragab et al.
David Kuttenkeuler et al.
Innate immune signalling pathways are evolutionarily conserved between invertebrates and vertebrates. The analysis of NF-kappaB signalling in Drosophila has contributed important insights into how organisms respond to infection. Nevertheles...
Characteristics and biological variations of M-ficolin, a pattern recognition molecule, in plasma [0.03%]
血浆模式识别分子M-乳酸清蛋白的特征及生物变异
Thomas Wittenborn,Steffen Thiel,Lisbeth Jensen et al.
Thomas Wittenborn et al.
The three human ficolins, H-ficolin, L-ficolin and M-ficolin, are pattern recognition molecules of the innate immune system. All three ficolins can activate the lectin pathway of the complement system after binding to pathogens. H- and L-fi...
Collagen VI is a subepithelial adhesive target for human respiratory tract pathogens [0.03%]
人呼吸道病原体的粘膜下靶标胶原VI蛋白质
Marta Bober,Charlotte Enochsson,Mattias Collin et al.
Marta Bober et al.
Bacterial engagement of specific host tissue structures can be a means of targeting a pathogen to a particular niche, establishing persistent infections and inducing invasion. In this context, primary adhesion is often the first crucial col...
Intranasal administration of CpG induces a rapid and transient cytokine response followed by dendritic and natural killer cell activation and recruitment in the mouse lung [0.03%]
CpG的鼻内给药诱导小鼠肺部快速而短暂的细胞因子反应，随后树突状和自然杀伤细胞被激活并募集
Isabella Pesce,Elisabetta Monaci,Alessandro Muzzi et al.
Isabella Pesce et al.
CpG-containing oligodeoxynucleotides are potent mucosal adjuvants and effective as stand-alone treatment of respiratory infections in mice. Although CpG is also used as a type 1 helper immunomodulator in the treatment of asthma and allergic...
Deletion of the mucin-like molecule muc1 enhances dendritic cell activation in response to toll-like receptor ligands [0.03%]
类似于粘蛋白的分子Muc1的缺失增强了树突状细胞对 Toll 样受体配基反应的活化作用
Marc A Williams,Stephen Bauer,Wenju Lu et al.
Marc A Williams et al.
Dendritic cells (DC) are potent professional antigen-presenting cells that drive primary immune responses to infections or other agonists perceived as 'dangerous'. Muc1 is the only cell surface mucin or MUC gene product that is expressed in...
Damon P Eisen
Damon P Eisen
Mannose-binding lectin (MBL) is an innate immune system pattern recognition protein that kills a wide range of pathogenic microbes through complement activation. A substantial proportion of all human populations studied to date have MBL def...
Regulation of aeroallergen immunity by the innate immune system: laboratory evidence for a new paradigm [0.03%]
固有免疫系统调节气传变应原免疫反应：实验室证据支持新观点
Anthony A Horner
Anthony A Horner
Over the last decade, it has become increasingly clear that innate responses to microbes are mediated largely by toll-like receptors (TLRs), which recognize a diverse family of molecules produced by viruses, bacteria and fungi. This article...
A new danger in the air: how pulmonary innate immunity copes with man-made airborne xenobiotics [0.03%]
空气中新的危险存在：肺固有免疫如何应对人工合成的气溶胶类外源物质
E A Lanckacker,L J Robays,G F Joos et al.
E A Lanckacker et al.
The pulmonary innate immune system has evolved over millions of years to provide swift detection of inhaled microbial agents and trigger well-balanced protective responses. Much more recent on the evolutionary scale is human activity, which...