The RNA from Pseudomonas aeruginosa Reduces Neutrophil Responses Favoring Bacterial Survival [0.03%]
铜绿假单胞菌的RNA通过减少中性粒细胞反应来促进细菌存活
Jose R Pittaluga,Federico Birnberg-Weiss,Agustina Serafino et al.
Jose R Pittaluga et al.
Introduction: Epithelial and endothelial cells modulate innate immune responses in the lung, including the arrival of neutrophils (PMN), which are crucial cells for the antibacterial host defense. Cells are exposed to pro...
Impact of Extreme Prematurity, Chorioamnionitis, and Sepsis on Neonatal Monocyte Characteristics and Functions [0.03%]
极端早产、绒毛膜羊膜炎和败血症对新生儿单核细胞特征和功能的影响
Khaleda Rahman Qazi,Dhanapal Govindaraj,Magalí Martí et al.
Khaleda Rahman Qazi et al.
Introduction: The innate branch of the immune system is important in early life, in particular for infants born preterm. Methods: We pe...
Randomized Controlled Trial
Journal of innate immunity. 2024;16(1):470-488. DOI:10.1159/000541468 2024
Inhibition of WNK Kinases in NK Cells Disrupts Cellular Osmoregulation and Control of Tumor Metastasis [0.03%]
WNK激酶抑制作用会破坏自然杀伤细胞的细胞渗透调节和肿瘤转移控制功能
Ji Sung Kim,John H Kehrl
Ji Sung Kim
Introduction: The serine/threonine with-no-lysine (WNK) kinase family function in blood pressure control, electrolyte homeostasis, and cellular osmoregulation. These kinases and their downstream effectors are considered p...
Meiyun Zhao,Xiaowu Tan,Xu Wu
Meiyun Zhao
Background: Respiratory diseases seriously threaten human health worldwide, and lung injury is an important component of respiratory disease. Complement activation is an important function of the innate immune system. Com...
Innate Immune Response to Monkeypox Virus Infection: Mechanisms and Immune Escape [0.03%]
猴痘病毒的固有免疫反应及逃逸机制研究进展
Reza Parnian,Fatemeh Heydarifard,Fatemeh Sadat Mousavi et al.
Reza Parnian et al.
Background: The reemergence of monkeypox virus (Mpox, formerly monkeypox) in 2022 in non-endemic countries has raised significant concerns for global health due to its high transmissibility and mortality rate. A major cha...
MDM2 Is Essential to Maintain the Homeostasis of Epithelial Cells by Targeting p53 [0.03%]
MDM2通过靶向p53维持上皮细胞稳态不可缺少
Su Wang,Shufen Zhong,Ying Huang et al.
Su Wang et al.
Introduction: MDM2 is known as the primary negative regulator of p53, and MDM2 promotes lung cancer fibrosis and lung injury through p53-dependent and p53-independent pathways. However, the mechanism by which MDM2 influen...
Dysregulation of Toll-Like Receptor Signaling-Associated Gene Expression in X-Linked Agammaglobulinemia: Implications for Correlations Genotype-Phenotype and Disease Expression [0.03%]
X连锁无丙种球蛋白血症中 toll 样受体信号相关基因表达失调：基因型-表型的相关性及疾病表现的意义
Marcelo Teocchi,Thaís de Andrade Eugênio,Lia Furlaneto Marega et al.
Marcelo Teocchi et al.
Introduction: In X-linked agammaglobulinemia (XLA), the diversity of BTK variants complicates the study of genotype-phenotype correlations. Since BTK negatively regulates toll-like receptors (TLRs), we investigated if dis...
Yuke Pan,Youyi Wang,Meinian Xu et al.
Yuke Pan et al.
Background: Atopic dermatitis (AD) is a chronic inflammatory skin condition characterized by recurrent eczematous lesions and severe pruritus. The economic burden and time penalty caused by the relapse of AD reduce patien...
Alice Prince
Alice Prince
Lipoteichoic Acids Are Essential for Pneumococcal Colonization and Membrane Integrity [0.03%]
脂磷壁酸对于肺炎链球菌定植和膜的完整性是必需的
Max Brendel,Thomas P Kohler,Janine V Neufend et al.
Max Brendel et al.
Introduction: The hydrophilic, polymeric chain of the lipoteichoic acid (LTA) of the Gram-positive pathobiont Streptococcus pneumoniae is covalently linked to the glycosylglycerolipid α-d-glucopyranosyl-(1,3)-diacylglyce...