Liver X receptors and inflammatory-induced C/EBPb selectively cooperate to control CD38 transcription [0.03%]
肝脏X受体和炎症诱导的C/EBPb合作控制CD38转录
Estibaliz Glaría,Pol Rodríguez Martínez,Joan Font-Díaz et al.
Estibaliz Glaría et al.
Introduction: Macrophages abundantly express liver X receptors (LXRs), which are ligand-dependent transcription factors and sensors of several cholesterol metabolites. In response to agonists, LXRs induce the expression o...
Does ATP via purinergic receptor signalling fuel pulmonary fibrosis? [0.03%]
ATP通过嘌呤能受体信号通路“煽风点火”促进肺纤维化吗？
Luke Forde,Debananda Gogoi,Rory Baird et al.
Luke Forde et al.
Background: Interstitial lung diseases (ILD) are poorly understood disorders characterised by diffuse damage to the lung parenchyma, with inflammation and fibrosis. Some manifest a progressive fibrotic phenotype with high...
Macrophage Evolution during Progression of Hepatitis virus B Related Acute-on-chronic Liver Failure [0.03%]
乙型肝炎相关亚急性重症肝衰竭进展过程中巨噬细胞的演化动力学研究
Jiawei Rao,Dongmei Ye,Ao Ren et al.
Jiawei Rao et al.
Introduction: Hepatitis B virus (HBV)-related liver diseases, including hepatitis, cirrhosis, and liver failure, seriously threaten human lives and health worldwide. Innate and adaptive immune cells are all thought to par...
Complex Thrombo-Inflammatory Responses versus Outcomes of Non-COVID-19 Community-Acquired Pneumonia and COVID-19 [0.03%]
复杂血栓炎症反应与社区获得性肺炎和新冠肺炎患者的预后关系研究
Greg Haljan,Terry Lee,Anne McCarthy et al.
Greg Haljan et al.
Introduction: The thrombo-inflammatory response and outcomes of community-acquired pneumonia (CAP) due to various organisms (non-COVID-19 CAP) versus CAP due to a single virus, SARS-CoV-2 (i.e., COVID-19) may differ. ...
Pore-forming toxin-like proteins in the anti-parasitoid immune response of Drosophila [0.03%]
果蝇抗寄生虫免疫反应中的类似孔道形成毒素的蛋白
Lilla B Magyar,Edit Ábrahám,Zoltán Lipinszki et al.
Lilla B Magyar et al.
Introduction: Species of the ananassae subgroup of Drosophilidae are highly resistant to parasitoid wasp infections. We have previously shown that the genes encoding Cytolethal Distending Toxin B (CdtB) and the Apoptosis ...
Human Blood Non-Classical/Classical Monocyte Cells Are Heterogeneously Presented in Severe COVID-19 and Correlate with Disease Activity [0.03%]
人血非经典/经典单核细胞在重症新冠患者中异质表达并可反映疾病活动度
Danhong Zhou,Yu Shen,Suxian Jing et al.
Danhong Zhou et al.
Introduction: COVID-19 is highly heterogeneous, ranging from cases with mild disease with an almost asymptomatic carrier to severe cases, in which the disease evolves rapidly. A better understanding of monocyte response d...
Differential Effector Function of Tissue-Specific Natural Killer Cells against Lung Tumors [0.03%]
针对肺癌的组织特异性自然杀伤细胞效应功能差异性研究
Zerick Terrell Dunbar,Salvador González-Ochoa,Thanigaivelan Kanagasabai et al.
Zerick Terrell Dunbar et al.
Introduction: Natural killer (NK) cells are innate lymphoid cells capable of directly killing target cells while modulating immune effector responses. Despite their multifunctional capacities, a limited understanding of t...
C4b-Binding Protein and Factor H Attenuate NLRP3 Inflammasome-Mediated Signalling Response during Group A Streptococci Infection in Human Cells [0.03%]
群链球菌感染过程中C4b结合蛋白和因子H通过下调NLRP3炎性小体信号反应发挥保护作用
Serena Bettoni,Mateusz Dziedzic,Damien Bierschenk et al.
Serena Bettoni et al.
Introduction: Streptococcus pyogenes (group A streptococcus; GAS) is a pathogen causing over half a million deaths annually worldwide. Human immune cells respond to GAS infection by activating the NLRP3 inflammasome leadi...
Analyzing the Role of Specific Damage-Associated Molecular Patterns-Related Genes in Osteoarthritis and Investigating the Association between β-Amyloid and Apolipoprotein E Isoforms [0.03%]
分析特定损伤相关分子模式相关基因在骨关节炎中的作用及β淀粉样蛋白与载脂蛋白E同种型之间的关联性研究
Fangling Yuan,Yatian Tang,Feifei Zheng et al.
Fangling Yuan et al.
Introduction: Osteoarthritis (OA) is a prevalent chronic joint disorder. It is characterized by an immune response that maintains a low level of inflammation throughout its progression. During OA, cartilage degradation le...
TLR2 and NLRP3 Orchestrate Regulatory Roles in Escherichia coli Infection-Induced Septicemia in Mouse Models [0.03%]
TLR2和NLRP3在小鼠肠杆菌感染诱导的败血症中发挥调控作用
Zhiguo Gong,Wei Mao,Jiamin Zhao et al.
Zhiguo Gong et al.
Introduction: Escherichia coli (E. coli) is a significant commensal gram-negative bacterium that can give rise to various diseases. The roles of Toll-like receptor 2 (TLR2) and the NOD-like receptor pyrin domain-containin...