Qilian Jiechang Ning Alleviates TNBS-Induced Ulcerative Colitis in Mice and Segatella copri Outer Membrane Vesicle-Triggered Inflammation in Colon Epithelial Cells via the Caspase-1/11-GSDMD Pathways [0.03%]
祁连捷畅宁通过调控Caspase-1/11-GSDMD通路改善溃疡性结肠炎小鼠及Segatella copri外膜囊泡诱导的结肠上皮细胞炎症反应
Jinyang Hu,Junjie Niu,Shisheng Jiang et al.
Jinyang Hu et al.
Introduction: Qilian Jiechang Ning (QJN), a traditional Chinese herbal formula, has demonstrated potential therapeutic effects in the treatment of ulcerative colitis (UC). This study aims to investigate the mechanism of Q...
Common haplotypes within the chromosome 1q31.3 region determine systemic concentrations of the entire complement factor H protein family [0.03%]
染色体1q31.3区域内的常见单倍型决定整个补体H蛋白家族的系统浓度
Bert R J Veuskens,Mara Van Rossum,Emi Cattenstart et al.
Bert R J Veuskens et al.
The alternative pathway (AP) of complement activation is consistently active, keeping the complement system primed for immediate response. This constant "tick-over" mechanism is regulated by the factor H (FH) protein family, which encompass...
Development and characterization of novel ELISAs for the specific quantification of the factor H-related proteins 2, 3, 4 and 5 [0.03%]
新型ELISA的开发和特征描述，用于特异性量化因子H相关蛋白2、3、4和5的数量
Mara van Rossum,Bert R J Veuskens,Mieke C Brouwer et al.
Mara van Rossum et al.
Background: The complement system's alternative pathway relies on factor H (FH) for immune homeostasis. Next to FH, a group of highly similar proteins was described known as FH-related (FHR) proteins. The FH protein famil...
CAPN1 Promotes Pseudomonas aeruginosa-Induced Infection by Interacting with TFEB and Inhibiting Autophagy [0.03%]
CAPN1通过与TFEB相互作用抑制自噬从而促进铜绿假单胞菌诱导的感染
Yueming Wu,Miaomiao Chen,Hua Chen et al.
Yueming Wu et al.
Introduction: Autophagy-lysosome pathways play a crucial role in the intracellular killing of pathogenic microorganisms. This study aimed to explore the mechanism by which acute lung injury (ALI) of Pseudomonas aeruginosa...
Unraveling the Complex Nexus of Macrophage Metabolism, Periodontitis, and Associated Comorbidities [0.03%]
巨噬细胞代谢、牙周炎及其相关共病的复杂联系解析
Zihan Zhang,Yi Liu,Tian Yu et al.
Zihan Zhang et al.
Periodontitis stands out as one of the most prevalent oral dysbiotic inflammatory diseases, ultimately leading to the irreversible destruction of periodontal tissue. Macrophages play a pivotal role in the development and progression of peri...
Streptococcus pyogenes activates human platelets via streptolysin S-mediated calcium ion influx [0.03%]
化脓链球菌通过链球菌素S介导的钙离子流入激活人血小板
Anna Riegner,Kristin Jahn,Jan Wesche et al.
Anna Riegner et al.
Introduction: Streptococcus pyogenes (group A streptococcus, GAS) is an exclusively human pathogen. It causes a wide spectrum of diseases, ranging from mild infections such as pharyngitis to severe life-threatening condit...
Neutrophils Display Novel Partners of Cytosolic Proliferating Cell Nuclear Antigen Involved in Interferon Response in COVID-19 Patients [0.03%]
中性粒细胞展示了新的细胞质增殖细胞核抗原胞内结合蛋白，其参与COVID-19患者的干扰素反应过程
Lucie Pesenti,Rodrigo de Oliveira Formiga,Nicola Tamassia et al.
Lucie Pesenti et al.
Introduction: Neutrophils are key players in the hyperinflammatory response during SARS-CoV-2 infection. The cytosolic proliferating cell nuclear antigen (PCNA) is a scaffolding protein highly dependent on the microenviro...
Exploring the Role of Macrophages and Their Associated Structures in Rheumatoid Arthritis [0.03%]
探讨类风湿性关节炎中巨噬细胞及其相关结构的作用
Xin Tian,Jingjing Chen,Yujie Hong et al.
Xin Tian et al.
Background: Rheumatoid arthritis (RA) is a chronic, invasive autoimmune disease characterized by symmetrical polyarthritis involving synovial inflammation. Epidemiological studies indicate that the incidence of RA continu...
Acinetobacter baumannii clinical isolates resist complement-mediated lysis by inhibiting the complement cascade and improperly depositing MAC [0.03%]
鲍曼不动杆菌临床分离株通过抑制补体级联反应和错误沉积MAC来抵抗补体介导的溶解作用
Michal Magda,Wendy Boschloo,Serena Bettoni et al.
Michal Magda et al.
Acinetobacter baumannii is a gram-negative opportunistic bacterium that causes life-threatening infections in immunocompromised hosts. The World Health Organization (WHO) recognizes the high mortality and increasing antimicrobial resistance...
5-methoxytryptophan protects against toll-like receptor 2 mediated renal tissue inflammation and fibrosis in a murine unilateral ureteral obstruction model [0.03%]
5-甲氧基色氨酸通过抑制TLR2信号通路减少单侧输尿管梗阻诱导的小鼠肾纤维化炎症反应
Jing-Yiing Wu,Guan-Lin Lee,Yu-Fan Chueh et al.
Jing-Yiing Wu et al.
Introduction: 5-methoxytryptophan (5-MTP) is an anti-inflammatory metabolite. Several recent reports indicate that 5-MTP protects against post-injury tissue fibrosis. It was unclear how 5-MTP controls tissue fibrosis. We ...